ChemicalBook > CAS DataBase List > N-Carbobenzoxy-L-homoserine

N-Carbobenzoxy-L-homoserine

Product Name
N-Carbobenzoxy-L-homoserine
CAS No.
35677-88-4
Chemical Name
N-Carbobenzoxy-L-homoserine
Synonyms
Cbz-hse-OH;Cbz-Homoserine;Cbz-L-Homoserine;N-Carbobenzoxy-L-homoserine;N-(Benzyloxycarbonyl)-L-homoserine;Cbz-HoMoser Cbz-HoMoserine Cbz-Hse;(S)-benzyl 2-amino-4-hydroxybutanoate;L-HoMoserine, N-[(phenylMethoxy)carbonyl]-;2-CarboxyaMino-4-hydroxybutyric acid, N-benzyl Ester;(2S)-4-hydroxy-2-(phenylmethoxycarbonylamino)butanoic
CBNumber
CB21568730
Molecular Formula
C12H15NO5
Formula Weight
253.25
MOL File
35677-88-4.mol
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N-Carbobenzoxy-L-homoserine Property

Melting point:
100-101 °C
Boiling point:
519.9±50.0 °C(Predicted)
Density 
1.311
storage temp. 
2-8°C
pka
3.85±0.10(Predicted)
form 
Solid
color 
White to off-white
optical activity
Consistent with structure
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C176580
Product name
N-Carbobenzoxy-L-homoserine
Packaging
1g
Price
$1055
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0002854
Product name
N-CARBOBENZOXY-L-HOMOSERINE
Purity
95.00%
Packaging
1G
Price
$820
Updated
2021/12/16
AK Scientific
Product number
W5720
Product name
Cbz-L-Homoserine
Packaging
100g
Price
$947
Updated
2021/12/16
ChemScene
Product number
CS-0062253
Product name
N-Carbobenzoxy-L-homoserine
Packaging
10g
Price
$244
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC19701
Product name
N-Cbz-L-homoserine
Packaging
5G
Price
$250
Updated
2021/12/16
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N-Carbobenzoxy-L-homoserine Chemical Properties,Usage,Production

Uses

N-Carbobenzoxy-L-homoserine (cas# 35677-88-4) is a compound useful in organic synthesis.

Synthesis

672-15-1

501-53-1

35677-88-4

General procedure for the synthesis of (S)-2-(((benzyloxy)carbonyl)amino)-4-hydroxybutyric acid from L-homoserine and benzyl chloroformate: L-homoserine (4.76 g, 40 mmol) was dissolved in a solvent mixture of H2O (200 mL) and 1,4-dioxane (50 mL). To this solution was added NaHCO3 (13.44 g, 160 mmol), followed by slow dropwise addition of benzyl chloroformate (6.76 mL, 48 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was washed twice with ethyl acetate (EA). The aqueous layer was neutralized to pH 2 with 4 mol/L HCl solution and then extracted with EtOAc. The organic layers were combined, washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The resulting crude product (8.86 g, 35 mmol, 87.5% yield) was used directly in the next reaction without further purification.

References

[1] Synthetic Communications, 1988, vol. 18, # 14, p. 1715 - 1722
[2] Journal of Organic Chemistry, 2003, vol. 68, # 7, p. 2668 - 2672
[3] Tetrahedron Letters, 2017, vol. 58, # 42, p. 3970 - 3973
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9133 - 9153
[5] Journal of Organic Chemistry, 1986, vol. 51, # 26, p. 5047 - 5050

N-Carbobenzoxy-L-homoserine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Carbobenzoxy-L-homoserine manufacturers

Career Henan Chemical Co
Product
N-Carbobenzoxy-L-homoserine 35677-88-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

35677-88-4, N-Carbobenzoxy-L-homoserineRelated Search:

L-Homoserine Trimethoprim L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE DL-Serine D-Cycloserine N-Carbobenzyloxyglycine N-CARBOBENZOXY-DL-ASPARTIC ACID Z-D-GLU-OH N-CARBOBENZOXY-DL-SERINE N-Cbz-D-Phenylalanine N-CBZ-HEXAHYDRO-1H-AZEPIN-4-ONE N-Cbz-L-homoserine lactone N-Cbz-L-Aspartic acid 4-tert-butyl ester Z-ASP(OME)-OH N-Carbobenzyloxy-L-aspartic acid Z-ASP-OBZL N-Cbz-Hydroxy-L-proline Z-ASP(OTBU)-OH DCHA

  • Cbz-hse-OH
  • N-(Benzyloxycarbonyl)-L-homoserine
  • N-Carbobenzoxy-L-homoserine
  • Cbz-L-Homoserine
  • Cbz-Homoserine
  • L-HoMoserine, N-[(phenylMethoxy)carbonyl]-
  • 2-CarboxyaMino-4-hydroxybutyric acid, N-benzyl Ester
  • Cbz-HoMoser Cbz-HoMoserine Cbz-Hse
  • (2S)-4-hydroxy-2-(phenylmethoxycarbonylamino)butanoic acid
  • (S)-2-(((Benzyloxy)carbonyl)amino)-4-hydroxybutanoic acid
  • (S)-benzyl 2-amino-4-hydroxybutanoate
  • (2S)-2-{[(benzyloxy)carbonyl]amino}-4-hydroxybutanoic acid
  • (2S)-4-hydroxy-2-(phenylmethoxycarbonylamino)butanoicaci
  • (2S)-4-hydroxy-2-(phenylmethoxycarbonylamino)butanoic
  • 35677-88-4
  • Amino Acids & Derivatives
  • Aromatics