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BOC-GLYCINE TERT-BUTYL ESTER

Product Name
BOC-GLYCINE TERT-BUTYL ESTER
CAS No.
111652-20-1
Chemical Name
BOC-GLYCINE TERT-BUTYL ESTER
Synonyms
N-Boc-gL;BOC-GLY-OTBU;N-BOC-Gly-OtBu;Boc-Gly-Ot<;Boc-Gly-Otbu-OH;Boc-Gly-OtBu, ≥98%;Boc-Gly-OtBu;BOC-GLYCINE T-BUTYL ESTER;BOC-GLYCINE TERT-BUTYL ESTER;(Tert-Butoxy)Carbonyl Gly-OtBu
CBNumber
CB2157582
Molecular Formula
C11H21NO4
Formula Weight
231.29
MOL File
111652-20-1.mol
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BOC-GLYCINE TERT-BUTYL ESTER Property

Melting point:
66-68 °C(lit.)
Boiling point:
306.0±25.0 °C(Predicted)
Density 
1.023
storage temp. 
2-8°C
solubility 
very soluble in Methanol
form 
powder to crystal
pka
11.06±0.46(Predicted)
color 
White to Almost white
Water Solubility 
1.05g/L at 20℃
BRN 
5002580
InChIKey
ZDKFMHKWZATBMR-UHFFFAOYSA-N
LogP
2.21 at 25℃
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Safety

Hazard Codes 
Xn
Risk Statements 
22-51
Safety Statements 
20/21-29/56
WGK Germany 
3
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H401Toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
423297
Product name
Boc-Gly-OtBu
Purity
99%
Packaging
5g
Price
$134
Updated
2023/06/20
TCI Chemical
Product number
B4156
Product name
N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
B4156
Product name
N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$54
Updated
2025/07/31
Usbiological
Product number
265310
Product name
Boc-glycine tert-butyl ester
Packaging
1g
Price
$358
Updated
2021/12/16
TRC
Product number
B656140
Product name
Boc-Gly-OtBu
Packaging
10mg
Price
$45
Updated
2021/12/16
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BOC-GLYCINE TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Whtie powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

27532-96-3

111652-20-1

Example 1 (Example of reaction formula (1)) [13]: tert-butyl glycinate hydrochloride (10.0 g, 59.7 mmol) was suspended in toluene (46.2 ml), heated to 60 °C and then triethylamine (6.51 g, 64.3 mmol) was added, and the reaction was stirred for 0.5 hours. Subsequently, a solution of di-tert-butyl dicarbonate (10.0 g, 45.9 mmol) in toluene (11.6 ml) was added slowly and dropwise to the reaction mixture and the reaction was continued for 6 hours. After completion of the reaction, it was quenched by addition of water (30 ml) and the organic layer was separated. The organic layer was distilled by azeotropic distillation with n-hexane to remove the solvent to afford tert-butyl N-Boc-glycinate (10.6 g, 45.9 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR analysis.

References

[1] Patent: CN103068795, 2016, B. Location in patent: Paragraph 0119; 0120; 0121; 0122; 0123; 0124
[2] Synthesis, 1987, # 3, p. 223 - 225
[3] The Journal of organic chemistry, 2002, vol. 67, # 24, p. 8291 - 8298

BOC-GLYCINE TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-GLYCINE TERT-BUTYL ESTER Suppliers

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View Lastest Price from BOC-GLYCINE TERT-BUTYL ESTER manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Gly-OtBU 111652-20-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-15
Henan Aochuang Chemical Co.,Ltd.
Product
Boc-Gly-OtBu 111652-20-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Boc-Gly-OtBu 111652-20-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

111652-20-1, BOC-GLYCINE TERT-BUTYL ESTERRelated Search:

BOC-Glycine N-Boc-L-phenylalaninal N-Boc-Ethylenediamine N-(tert-Butoxycarbonyl)-4-piperidone Boc-L-glutamic acid 1-tert-butyl ester (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER Boc-Asp-OtBu BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-1-BOC-N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID T-BUTYL ESTER Glycine BOC-SER(TBU)-OH BOC-D-ASP-OTBU BOC-ORN-OTBU HCL N-BOC-4-NITRO-L-PHENYLALANINE-T-BUTYL ESTER BOC-GLU(OSU)-OTBU BOC-L-THIOCITRULLINE-OTBU BOC-ALA-OTBU BOC-D-GLU-OTBU

  • Boc-Gly-O<I>t</I>Bu
  • tert-Butyl 2-((tert-butoxycarbonyl)aMino)acetate
  • N-(tert-Butoxycarbonyl)glycine tert-butyl ester (tert-Butoxycarbonylamino)acetic acid tert-butyl ester
  • tert-butyl 2-(tert-butoxycarbonyl)acetate
  • tert-butyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
  • Boc-glycinetert-butyl ester≥ 98% (HPLC)
  • N-Boc-glycine tert-butyl ester, 95%
  • (Tert-Butoxy)Carbonyl Gly-OtBu
  • BOC-GLYCINE T-BUTYL ESTER
  • BOC-GLYCINE TERT-BUTYL ESTER
  • BOC-GLY-OTBU
  • N-(TERT-BUTOXYCARBONYL)GLYCINE TERT-BUTYL ESTER
  • N-alpha-t-Butyloxycarbonyl-glycine t-butyl ester
  • Glycine, N-[(1,1-diMethylethoxy)carbonyl]-, 1,1-diMethylethyl ester
  • (tert-Butoxycarbonylamino)acetic acid tert-butyl ester
  • N-BOC-Gly-OtBu
  • Boc-Gly-OtBu, ≥98%
  • N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester &gt
  • N-Boc-gL
  • ert-butyl2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
  • BOC-GLYCINE TERT-BUTYL ESTER USP/EP/BP
  • Tert butyloxycarbonylglycine tert butyl ester
  • N-(tert-Butoxycarbonyl)glycine tert-Butyl Este
  • Boc-Gly-Otbu-OH
  • Boc-Gly-O<I>t<
  • tert-butyl N-(tert-butoxycarbonyl)glycinate
  • N-Boc-glycine tert-Butyl Ester
  • 111652-20-1
  • CH33COCONHCH2CO2CCH33
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Acid Derivatives