Boldine

Product Name: Boldine
CAS No.: 476-70-0
Chemical Name: Boldine
Synonyms: boldin;(s)-yl;BOLDINE;BOLDINE(RG);(s)-boldine;Boldine CRS;(+)-boldine;(+)-(s)-boldine;ex Peumus boldus;boldine--chloroform
CBNumber: CB2167570
Molecular Formula: C19H21NO4
Formula Weight: 327.37
MOL File: 476-70-0.mol

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Boldine Property

Melting point:: 162-164 °C
Boiling point:: 465.27°C (rough estimate)
Density: 1.2223 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C
solubility: Acetonitrile (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form: Solid
pka: 9.75±0.20(Predicted)
color: Yellow to Dark Brown
Merck: 13,1316
BRN: 94036
LogP: 0.837 (est)
CAS DataBase Reference: 476-70-0(CAS DataBase Reference)
EPA Substance Registry System: 4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)- (476-70-0)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 1-20-24/25-45-36-26
RIDADR: 1544
WGK Germany: 3
RTECS: CE0750000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002060
Product name: Boldine for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 20 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000434
Product name: Boldine
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 30 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: B3916
Product name: Boldine
Purity: analytical standard
Packaging: 1g
Price: $21.7
Updated: 2022/05/15

Cayman Chemical

Product number: 18447
Product name: Boldine
Purity: ≥95%
Packaging: 1g
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 18447
Product name: Boldine
Purity: ≥95%
Packaging: 5g
Price: $94
Updated: 2024/03/01

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Boldine Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata.

Uses

antineoplastic

Uses

boldine is attributed with strong anti-oxidant properties. It has also demonstrated an ability to protect against uVB rays. Boldine is a constituent of the boldo plant (Peumus boldus Mol.) native to Chile, and is found in the plant’s leaves and bark.

Definition

ChEBI: Boldine is an aporphine alkaloid.

in vivo

Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways^[3].

Animal Model:	DSS-induced mice model^[3]
Dosage:	50 mg/kg
Administration:	p.o.
Result:	Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO) Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA) Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.

Boldine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boldine Suppliers

China 152 France 3 Germany 2 India 2 Switzerland 1 United Kingdom 5 United States 24 Global 189

Carbosynth

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Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Leancare Ltd.

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Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

MOLEKULA Ltd.

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Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

ETA SCIENTIFIC Co.,Ltd

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Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

Sequoia Research Products Ltd.

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Email: sales@seqchem.com
Country: United Kingdom
ProdList: 3113
Advantage: 69

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View Lastest Price from Boldine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Boldine 476-70-0
Price: US $1.00-45.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 420000KG
Release date: 2024-08-05

Career Henan Chemical Co

Product: Boldine 476-70-0
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

476-70-0, BoldineRelated Search:

LINDERANE LAUROLITSINE Linderene acetate Pyruvic acid Methylparaben Colchicine (-)-Huperzine A Sophoridine BOLDINE HYDROCHLORIDE(RG),BOLDINE HYDROCHLORIDE BOLDINE DIMETHYL ETHER 4H-Dibenzo(de,g)quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6 -methyl-, (S)- Thalicarpine L-DICENTRINE DIACETYL BOLDINE Boldine BOLDOSTANDARDEXTRACT,0.2%BOLDINE BoldoS.E.0.05%Boldine,PeumusBoldus AKOS 208-03

(+)-(s)-boldine

(s)-boldine

(s)-yl

1,10-dimethoxy-6a-alpha-aporphine-2,9-diol

1,10-dimethoxy-6a-alpha-aporphine-9-diol

4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth

4h-dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl

boldin

boldine--chloroform

BOLDINE(RG)

BOLDINE

BOLDO STANDARD EXTRACT

2 6-DIHYDROXY-3 5-DIMETHOXYAPORPHIN

2,9-DIHYDROXY-1,10-DIMETHOXYAPORPHINE

1,10-DIMETHOXY-2,9-DIHYDROXYAPORPHINE

2,9-Dihydroxy-1,10-dimethoxyaporphine, Boldine

(-)-6-Methyl-1,10-dimethoxy-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol

(6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol

4H-Dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-diMethoxy-6-Methyl-, (6aS)-

Boldine CRS

ex Peumus boldus

(6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol

(+)-boldine

(S)-1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol

*Tramadol Impurity 25

476-70-0

C19H21NO4

BI - BZ

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