ChemicalBook > CAS DataBase List > 2-(1-Piperazinyl)pyrimidine

2-(1-Piperazinyl)pyrimidine

Product Name: 2-(1-Piperazinyl)pyrimidine
CAS No.: 20980-22-7
Chemical Name: 2-(1-Piperazinyl)pyrimidine
Synonyms: 1-(2-PYRIMIDYL)PIPERAZINE;1-pp;PMPRZ;mj13653;GOSO-003;BUSPIRON?A;AKOS BBS-00003690;TIMTEC-BB SBB003913;RARECHEM AH CK 0195;Pyrimidinylpiperazine
CBNumber: CB2169600
Molecular Formula: C8H12N4
Formula Weight: 164.21
MOL File: 20980-22-7.mol

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2-(1-Piperazinyl)pyrimidine Property

Melting point:: 32-34°C
Boiling point:: 277 °C (lit.)
Density: 1.158 g/mL at 25 °C (lit.)
refractive index: n20/D 1.587(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid After Melting
pka: 8.68±0.10(Predicted)
color: Clear yellow
Water Solubility: almost transparency
Sensitive: Hygroscopic
BRN: 151178
InChIKey: MRBFGEHILMYPTF-UHFFFAOYSA-N
CAS DataBase Reference: 20980-22-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
RTECS: UV9702000
TSCA: Yes
HazardClass: 8
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2845
Product name: Buspirone Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 2X100MG
Price: $521
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1078573
Product name: Buspirone Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 2x75mg
Price: $1330
Updated: 2025/07/31

Sigma-Aldrich

Product number: 421235
Product name: 1-(2-Pyrimidyl)piperazine
Purity: 98%
Packaging: 5g
Price: $35.5
Updated: 2023/06/20

TCI Chemical

Product number: P1110
Product name: 1-(2-Pyrimidyl)piperazine
Purity: >98.0%(GC)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: P1110
Product name: 1-(2-Pyrimidyl)piperazine
Purity: >98.0%(GC)
Packaging: 25g
Price: $69
Updated: 2025/07/31

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2-(1-Piperazinyl)pyrimidine Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid after melting

Uses

2-(1-Piperazinyl)pyrimidine (Buspirone EP Impurity A) is the major metabolite of Tandospirone (T006430).

Uses

The major metabolite of Tandospirone.

Definition

ChEBI: 1-(2-Pyrimidyl)piperazine is a N-arylpiperazine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 18, p. 1484, 1953 DOI: 10.1021/jo50017a004

General Description

1-(2-Pyrimidyl)piperazine is a piperazine-based derivative. It is a metabolite of buspirone.

Synthesis

110-85-0

1722-12-9

20980-22-7

Generic method: 2-chloro-4,6-disubstituted pyrimidines (17) were prepared by reaction of the diazonium salt of 4,6-disubstituted pyrimidin-2-amine (16) with concentrated hydrochloric acid and ZnCl?[35]. Compound 18 was synthesized with reference to the method of literature [32] with modifications. To a stirred solution of piperazine (45 mmol) and K?CO? (16.5 mmol) in water (20 mL) was added 2-chloro-4,6-disubstituted pyrimidine (17) (18 mmol) in batches at 50-65 °C. The reaction mixture was stirred at 60-65 °C for 1 hour and subsequently cooled to 35 °C. The solid by-product 1,4-bispyrimidinylpiperazine was removed by filtration, the filtrate was extracted three times with chloroform, the organic phase was dried with Na?SO? and concentrated under reduced pressure to give compound 18, which could be used in the subsequent reaction without further purification.18a: yellow oil, 88% yield.

References

[1] Chinese Journal of Chemistry, 2015, vol. 33, # 10, p. 1124 - 1134
[2] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 167 - 178
[3] Organic Letters, 2016, vol. 18, # 20, p. 5272 - 5275
[4] Journal of the American Chemical Society, 2017, vol. 139, # 33, p. 11357 - 11360
[5] Patent: CN107216318, 2017, A. Location in patent: Paragraph 0021; 0024; 0027

2-(1-Piperazinyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

Buspirone Tandospirone Doxazosin

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View Lastest Price from 2-(1-Piperazinyl)pyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-(1-Piperazinyl)pyrimidine 20980-22-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-26

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-(1-Piperazinyl)pyrimidine 20980-22-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-13

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-(1-Piperazinyl)pyrimidine 20980-22-7
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

20980-22-7, 2-(1-Piperazinyl)pyrimidineRelated Search:

2-Ethylhexyl ferulate Piperazine Piperacillin 1-Methylpiperazine N-Aminoethylpiperazine Homopiperazine 2-Chloropyrimidine Dihydrochloride BUSPIRONE (D8) 3,3-Tetramethyleneglutarimide Buspirone EP Impurity F 8-(pyrimidin-2-yl)-5,8-diazaspiro[4.5]decan-5-ium chloride Buspirone Impurity 1 (Lactone of 6-Hydroxy Buspirone) 8-(4-Chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione Buspirone EP Impurity H Buspirone Impurity 2 Buspirone N-Oxide Buspirone impurity 3

LABOTEST-BB LT00233196

AKOS BBS-00003690

1-PYRIMIDYL PIPERAZINE

2-(1-PIPERAZINYL)PYRIMIDINE

2-PIPERAZINOPYRIMIDINE

2-PIPERAZIN-1-YLPYRIMIDINE

1-(2-PYRIMIDINYL)PIPERAZINE

1-(2-PYRIMIDYL)PIPERAZINE

1-Pyrimydinyl Piperazine

RARECHEM AH CK 0195

TIMTEC-BB SBB003913

PMPRZ

1-(Pyrimidin-2-yl)piperazine 98%

1-(2-PYRIMIDINYL)PIPERZINE

1-(2-PYRIMIDINYL)PIPERZINE DIHYDROCHLORIDE

2-(1-Piperazinyl)pyrimidine, 98+%

1-(2-PYRIMIDYL)PIPERAZINE 98%

1-(2-PYRIMIDYL)PIPERAZINE DIHYDROCHLORIDE, 98+%

1-(2-Pyrimidyl)piperazine dihydrochloride

1-(2-Pyrimidyl)piperazine ,98%

2-Piperazinylpyrimidine

2-(piperazine-1-yl)-pyriMidine

PyriMidine, 2-(1-piperazinyl)-

N - (2 - pyriMidine base) piperazine

GOSO-003

Buspirone Impurity 1(Buspirone EP Impurity A)

Buspirone EP Impurity A

2-(1-Piperazinyl)pyrimidine,99%

Buspirone Related Compound A

1-pp

2-(1-piperazinyl)-pyrimidin

4-(2-pyrimidinyl)piperazine

mj13653

n-(2-pyrimidinyl)piperazine

2-(1-Piperazino)pyrimidine

1-(Pyrimidin-2-yl)piperazine

2-(Piperazin-1-yl)pyrimidine 98%

1-(2-Pyrimidinyl)piperazine 98% min

2-(2-Piperazinyl)pyrimidine

N-(2-pyridinyl)piperazine

1-(2-Pyrimidyl)piperazine&gt

Buspirone EP Impurity A/ Buspirone Related Compound A

Buspirone EP Impurity AQ: What is Buspirone EP Impurity A Q: What is the CAS Number of Buspirone EP Impurity A Q: What is the storage condition of Buspirone EP Impurity A Q: What are the applications of Buspirone EP Impurity A

TIANFU CHEM 2-(1-Piperazinyl)pyrimidine

Buspirone Related Compound A (75 mg x 2) (2-(Piperazin-1-yl)pyrimidine) (1078573)

Di2-(Piperazin-1-yl)pyrimidine

RSYY（Donepezil Hydrochloride)-16

2-Piperazinyl Pyrimidine, Hydrobromide（1：2）

BUSPIRON?A

Buspirone EP Impurity A Buspirone USP RC A

2-(1-Piperazinyl)pyrimidine, 10 mM in DMSO

Pyrimidinylpiperazine

Buspirone EP Impurity A (Buspirone USP Related Compound A)

20980-22-7

C8H13N4

C8H12N4

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