overview Salvia Chemical properties Uses
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Sclareol

overview Salvia Chemical properties Uses
Product Name
Sclareol
CAS No.
515-03-7
Chemical Name
Sclareol
Synonyms
SCIADONIC ACID;Natural sclareol;1-Naphthalenepropanol, α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-, (αR,1R,2R,4aS,8aS)-;SCAREOL;SCLAREOL;Aids046592;SCLAREOL(P);Aids-046592;SCLAREOL(RG);Sclareol 98%
CBNumber
CB2173575
Molecular Formula
C20H36O2
Formula Weight
308.51
MOL File
515-03-7.mol
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Sclareol Property

Melting point:
95-100 °C (lit.)
Boiling point:
218-220 °C/19 mmHg (lit.)
alpha 
-13 º (c=4, in carbon tetrachloride)
Density 
0.954±0.06 g/cm3(Predicted)
FEMA 
4502 | (-)-SCLAREOL
storage temp. 
2-8°C
solubility 
Chlorform, Ethyl Acetate (Slightly)
pka
14.49±0.29(Predicted)
color 
White to Off-White
Odor
at 100.00 %. sweet balsam clary amber woody weedy
Odor Type
balsamic
optical activity
[α]25/D 13°, c = 4 in carbon tetrachloride
JECFA Number
2029
BRN 
2054148
InChIKey
XVULBTBTFGYVRC-HHUCQEJWSA-N
LogP
5.54
CAS DataBase Reference
515-03-7(CAS DataBase Reference)
NIST Chemistry Reference
1-Naphthalenepropanol, «alpha»-ethenyldecahydro-2-hydroxy-«alpha»,2,5,5,8a-pentamethyl-, [1r-[1«alpha»(r*),2«beta»,4a«beta»,8a«alpha»]]-(515-03-7)
EPA Substance Registry System
Sclareol (515-03-7)
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Safety

WGK Germany 
2
RTECS 
QK0301900
HS Code 
29061990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W450210
Product name
Sclareol
Purity
natural, ≥95%, FG
Packaging
SAMPLE-K
Price
$62.2
Updated
2024/03/01
Sigma-Aldrich
Product number
W450210
Product name
Sclareol
Purity
natural, ≥95%, FG
Packaging
100G
Price
$295
Updated
2024/03/01
Sigma-Aldrich
Product number
W450210
Product name
Sclareol
Purity
natural, ≥95%, FG
Packaging
1KG
Price
$684
Updated
2024/03/01
Sigma-Aldrich
Product number
49944
Product name
Sclareol
Purity
analytical standard
Packaging
100mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
357995
Product name
Sclareol
Purity
98%
Packaging
1g
Price
$83.6
Updated
2024/03/01
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Sclareol Chemical Properties,Usage,Production

overview

Sclareol is a white crystalline powder extracted from the stems and leaves of the natural plant, Salvia Sclare L., with a melting point of 95-105 ° C and a weak Amber (Long saliva) aroma, delicate aroma, strong diffusion and long lasting fragrance. It is an ideal raw material for the synthesis of ambergris products. It is mainly used in the synthesis of natural dragon such as sclareolide and Ambroxide substitutes; a smaller amount of sclareol is also used for the allocation of flavors. In the field of medicine, it is used for anti-bacterial, anti-inflammatory, cholagogue, anti-cancer. In the field of pesticides, it is used for the prevention and control of crop rust, powdery mildew, insecticidal, and mediating the activity plant growth and plant defense function.

Salvia

Salvia is also known as Salvia sclar, rosette sage. With biennial or perennial Labiaceae sage, it is about 1 to 2 meters high. With the lower stem lignification, upright, branched, the whole plant is covered with wholly short hairs. It is unifoliate opposite, ovate or oblong. With verticillate inflorescence, the bisexual flowers are pink or pale purple or white. The bracts are broadly ovate, and corolla appears in snow-blue. Nutlets ovoid, grayish brown, smooth. The flowering period from June to July; seeds mature in July.
It is a sun-loving plant and resistant to cold, drough and barren, but fear of waterlogging. Seedlings are not resistant to shade.
The Origin is southern Europe. China has introduced salvia in the fifties. Now salvias are distributed in Shanxi, Hebei, Henan, Zhejiang and other provinces. The products of salvias which specially grow in the shallow mountainous areas of northern Shanxi, contain high ester aroma and pure, due to the large temperature difference between temperature and humidity in the region, and the altitude which is particularly suitable for the growth of herbal medicine.
Salvia has wide adaptability and cold, drought, barren tolerance. Seedlings are afraid of waterlogging, with the ability of living in-8 ℃ to-10 ℃.Adult plants can tolerate the temperature about-25 ℃. Early flowering period needs to have enough water to get high yield. For the seed propagation, the autumn is more suitable. The raw materials of salvia can be harvested in the late June of the following year. It should be planted in the spring, if the growth environment is parks or gardens.

Chemical properties

It is a white crystals. Boiling point> 340 ℃, melting point 101-103 ℃, specific rotation-11 °, soluble in 95% ethanol and oil. With a very weak amber aroma and lasting aroma.

Uses

(1) It is mainly used for the synthesis of ambergris-amber fragrance, and more suitable for perfume and essence when utilizing its aroma-retaining ability for blending.
(2) It is also used for flavor, spices, cigarettes, cosmetics, health food, food additives.

Uses

antineoplastic, apoptosis inducer

Uses

Sclareol is used in biological studies as it has anti-inflammatory activity in both lipopolysaccharide-stimulated macophages and λ-carrageenan-induced paw edema model.

Uses

Sclareol may be used as a starting material in the synthesis of ambergris fragrance chemicals such as ambraoxide, ambrox, methylambraoxide, ambracetal, ambraketal and epiambraketal. It may also be used in the synthesis of (+)-galanolactone, (-)-8-epi-galanolactone and (+)-labdienedial.

Definition

ChEBI: A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.

General Description

Sclareol, a diterpene compound with a labdane skeleton, is mainly used as a raw material in the fragrance industry. It shows potent cytotoxic and cytostatic effect in human leukemic cell lines.

Cytotoxicity

IC50 (μg/mL): 16.6 (HeLa), 32.65 (MCF7),65.2 μM (MG63) (Farimani et al. 2014).

Sclareol Preparation Products And Raw materials

Raw materials

Preparation Products

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Sclareol Suppliers

Canada 1 China 288 Czech Republic 1 Europe 2 France 2 Germany 3 India 5 Japan 1 Spain 1 Switzerland 2 United Kingdom 6 United States 40 USA 1 Global 353
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View Lastest Price from Sclareol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Sclareol 515-03-7
Price
US $60.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-08
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Sclareol 515-03-7
Price
US $0.00/KG
Min. Order
1KG
Purity
≥98% HPLC
Supply Ability
1000KG
Release date
2022-09-23
Shanghai Affida new material science and technology center
Product
Sclareol 515-03-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
50000KG/month
Release date
2024-04-25

515-03-7, SclareolRelated Search:

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  • 1-Naphthalenepropanol, .alpha.-ethenyldecahydro-2-hydroxy-.alpha.,2,5,5,8a-pentamethyl-, (.alpha.R,1R,2R,4aS,8aS)-
  • SCLAREOL(P)
  • SCLAREOL(RG)
  • (1R-(1alpha(R*),2beta,4abeta,8aalpha))-2-Hydroxy-alpha,2,5,5,8a-pentamethyl-alpha-vinyldecahydronaphthalin-1-propan-1-ol
  • .alpha.-ethenyldecahydro-2-hydroxy-.alpha.,2,5,5,8a-pentamethyl-, [1R-[1.alpha.(R*),2.beta.,4a.beta1-Naphthalenepropanol
  • SCAREOL
  • 1-Naphthalenepropanol, α-ethenyldecahydro- 2-hydroxy-α,2,5,5,8a-pentamethyl-, [1R-[1α(R),2,4a,8aα]]-
  • Clary Sage Concrete
  • Sclareol(Crude)
  • 1-naphthalenepropanol,decahydro-alpha-ethenyl-2-hydroxy-alpha,2,5,5,8a-pentame
  • Labd-14-ene-8,13-diol, (13R)-
  • [1R-[1alpha(R*),2beta,4abeta,8aalpha]]-2-hydroxy-alpha,2,5,5,8a-pentamethyl-alpha-vinyldecahydronaphthalene-1-propan-1-ol
  • SCLAREOL 95+%
  • (1R,2R,8AS)-DECAHYDRO-1-(3-HYDROXY-3-METHYL-4-PENTENYL)-2,5,5,8A-TETRAMETHYL-2-NAPHTHOL
  • SCIADONIC ACID
  • SCLAREOL, NATURAL
  • 1-Naphthalenepropanol, alpha-ethenyldecahydro-2-hydroxy-alpha,2,5,5,8A-pentamethyl-, (alphar,1R,2R,4as,8as)-: (1R,2R,4as,8as)-1-[(3R)-3-hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8A-tetramethyldecahydronaphthalen-2-ol
  • Aids046592
  • Aids-046592
  • SALSOLINOL HYDROBROMIDE(RG)(CALL)
  • Sclareol,(1R,2R,8aS)-Decahydro-1-(3-hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyl-2-naphthol
  • Sclareol 515-03-7
  • SCLAREOL
  • (13r)-labd-14-ene-13-diol
  • (1r-(1-alpha(r*),2-beta,4a-beta,8a-alpha))-thyl
  • .alpha.-ethenyldecahydro-2-hydroxy-.alpha.,2,5,5,8a-pentamethyl-,[1R-[1.alpha.(R*),2.beta.,4a.beta1-Naphthalenepropanol
  • [1theta-[1alpha(theta),2beta,4abeta,8aalpha]]-thyl
  • 1-(3-Hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyldecahydro-2-naphthalenol
  • 1-Naphthalenepropanol, alpha-ethenyldecahydro-2-hydroxy-alpha,2,5,5,8a-pentamethyl-, [1R-[1alpha(R*),2beta,4abeta,8aalpha]]-
  • 1-naphthalenepropanol,alpha-ethenyldecahydro-2-hydroxy-alpha,2,5,5,8a-pentame
  • (1R,2R,4aS,8aS)-1-((R)-3-hydroxy-3-Methylpent-4-en-1-yl)-2,5,5,8a-tetraMethyldecahydronaphthalen-2-ol
  • Sclareol 98%
  • 1-Naphthalenepropanol, α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-, (αR,1R,2R,4aS,8aS)-
  • 1-Naphthalenepropanol,a-ethenyldecahydro-2-hydroxy-a,2,5,5,8a-pentaMethyl-,(aR,1R,2R,4aS,8aS)-
  • Sclareol, 98%, Semi synthetic Semi synthetic
  • Sclareol (~90%)
  • Sclareol &gt
  • Natural sclareol
  • (-)-Sclareol
  • (1R,2R,4aS,8aS)-1-[(3R)-3-hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
  • Nano-Liposomal SCLAREOL, Water-Soluble SCLAREOL
  • 1-Naphthalenepropanol, α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-, (αR,1R,2R,4aS,8aS)-
  • 515-03-7
  • 0515-03-07
  • C20H36O2C20H36O2
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