TOLRESTAT

Product Name: TOLRESTAT
CAS No.: 82964-04-3
Chemical Name: TOLRESTAT
Synonyms: CS-148;Lorestat;AY-27773;Alredase;Aldredase;TOLRESTAT;Tolrestatin;Tolrestat, AY 27773;TOLRESTAT USP/EP/BP;TOLRESTAT(FORR&DONLY)
CBNumber: CB2174693
Molecular Formula: C16H14F3NO3S
Formula Weight: 357.35
MOL File: 82964-04-3.mol

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TOLRESTAT Property

Melting point:: 164-165°
Boiling point:: 498.1±55.0 °C(Predicted)
Density: 1.399±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form: powder
pka: 3.49±0.10(Predicted)
color: white to beige
CAS DataBase Reference: 82964-04-3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1573
Product name: Tolrestat
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $117
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1573
Product name: Tolrestat
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $478
Updated: 2023/06/20

Cayman Chemical

Product number: 29693
Product name: Tolrestat
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29693
Product name: Tolrestat
Packaging: 25mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 29693
Product name: Tolrestat
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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TOLRESTAT Chemical Properties,Usage,Production

Description

Tolrestat is a long-acting aldose reductase inhibitor reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy and cataracts.

Description

Tolrestat is an aldose reductase inhibitor (IC₅₀ = 35 nM for the bovine lens enzyme). Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED₅₀ = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED₅₀ = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day. Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.

Originator

American Home Products (USA)

Uses

Tolrestat is an aldose reductase inhibitor.

Uses

Alredase (Wyeth-Ayerst).

Definition

ChEBI: Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.

brand name

Alredase

Biochem/physiol Actions

Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.

TOLRESTAT Preparation Products And Raw materials

Raw materials

Phosphorus pentasulfide 1-Naphthoic acid Glycine methyl ester hydrochloride 1,5-DIMETHYLNAPHTHALENE Sarcosine

Preparation Products

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TOLRESTAT Suppliers

China 72 Europe 2 France 1 Germany 1 India 1 United Kingdom 2 United States 18 Global 97

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
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Shanghai Sphchem Co., Ltd.

Tel: 21-21-56491756 13512199871
Fax: 021-5649-1756
Email: sales@panhongchem.com
Country: China
ProdList: 3985
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
Advantage: 60

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
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Country: China
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ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
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Country: China
ProdList: 8011
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

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View Lastest Price from TOLRESTAT manufacturers

Dideu Industries Group Limited

Product: TOLRESTAT 82964-04-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-15

82964-04-3, TOLRESTATRelated Search:

Naphthalene Naftifine Stearic acid Anthracene Acetonitrile Oxalic acid dihydrate Benzyl alcohol Tolrestat S-oxide alpha,alpha,alpha-Trifluoro-o-cresol TOLRESTAT 2-(TRIFLUOROMETHYL)ANISOLE N-methylthiobenzamide 1-TRIFLUOROMETHYL-NAPHTHALENE

TOLRESTAT

TOLRESTAT(FORR&DONLY)

Alredase

AY-27773

Lorestat

N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine

Aldredase

N-[[6-Methoxy-5-(trifluoromethyl)naphthalen-1-yl]thioxomethyl]-N-methylglycine

[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carbothioyl)-methyl-amino]-acetic acid

2-(6-Methoxy-N-Methyl-5-(trifluoroMethyl)naphthalene-1-carbothioaMido)acetic acid

Tolrestatin

TolrestattolrestattolrestatTolrestat

CS-148

Tolrestat, AY 27773

AY-27773;AY 27773; AY27773

Glycine, N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-

TOLRESTAT USP/EP/BP

Inhibitor,inhibit,Tolrestat,AY 27773,Aldose Reductase,AY27773

82964-04-3