TOLRESTAT
- Product Name
- TOLRESTAT
- CAS No.
- 82964-04-3
- Chemical Name
- TOLRESTAT
- Synonyms
- CS-148;Lorestat;AY-27773;Alredase;Aldredase;TOLRESTAT;Tolrestatin;Tolrestat, AY 27773;TOLRESTAT USP/EP/BP;TOLRESTAT(FORR&DONLY)
- CBNumber
- CB2174693
- Molecular Formula
- C16H14F3NO3S
- Formula Weight
- 357.35
- MOL File
- 82964-04-3.mol
TOLRESTAT Property
- Melting point:
- 164-165°
- Boiling point:
- 498.1±55.0 °C(Predicted)
- Density
- 1.399±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- powder
- pka
- 3.49±0.10(Predicted)
- color
- white to beige
- CAS DataBase Reference
- 82964-04-3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1573
- Product name
- Tolrestat
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $117
- Updated
- 2023/06/20
- Product number
- SML1573
- Product name
- Tolrestat
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $478
- Updated
- 2023/06/20
- Product number
- 29693
- Product name
- Tolrestat
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29693
- Product name
- Tolrestat
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 29693
- Product name
- Tolrestat
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
TOLRESTAT Chemical Properties,Usage,Production
Description
Tolrestat is a long-acting aldose reductase inhibitor reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy and cataracts.
Description
Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme). Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day. Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.
Originator
American Home Products (USA)
Uses
Tolrestat is an aldose reductase inhibitor.
Uses
Alredase (Wyeth-Ayerst).
Definition
ChEBI: Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.
brand name
Alredase
Biochem/physiol Actions
Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.