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TOLRESTAT

Product Name
TOLRESTAT
CAS No.
82964-04-3
Chemical Name
TOLRESTAT
Synonyms
CS-148;Lorestat;AY-27773;Alredase;Aldredase;TOLRESTAT;Tolrestatin;Tolrestat, AY 27773;TOLRESTAT USP/EP/BP;TOLRESTAT(FORR&DONLY)
CBNumber
CB2174693
Molecular Formula
C16H14F3NO3S
Formula Weight
357.35
MOL File
82964-04-3.mol
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TOLRESTAT Property

Melting point:
164-165°
Boiling point:
498.1±55.0 °C(Predicted)
Density 
1.399±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form 
powder
pka
3.49±0.10(Predicted)
color 
white to beige
CAS DataBase Reference
82964-04-3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1573
Product name
Tolrestat
Purity
≥98% (HPLC)
Packaging
5MG
Price
$117
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1573
Product name
Tolrestat
Purity
≥98% (HPLC)
Packaging
25MG
Price
$478
Updated
2023/06/20
Cayman Chemical
Product number
29693
Product name
Tolrestat
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29693
Product name
Tolrestat
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
29693
Product name
Tolrestat
Packaging
1mg
Price
$32
Updated
2024/03/01
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TOLRESTAT Chemical Properties,Usage,Production

Description

Tolrestat is a long-acting aldose reductase inhibitor reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy and cataracts.

Description

Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme). Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day. Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.

Originator

American Home Products (USA)

Uses

Tolrestat is an aldose reductase inhibitor.

Uses

Alredase (Wyeth-Ayerst).

Definition

ChEBI: Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.

brand name

Alredase

Biochem/physiol Actions

Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.

TOLRESTAT Preparation Products And Raw materials

Raw materials

Phosphorus pentasulfide 1-Naphthoic acid Glycine methyl ester hydrochloride 1,5-DIMETHYLNAPHTHALENE Sarcosine

Preparation Products

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TOLRESTAT Suppliers

China 74 Europe 2 France 1 Germany 1 India 1 United Kingdom 2 United States 18 Global 99
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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70
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
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60
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62

82964-04-3, TOLRESTATRelated Search:

Naphthalene Naftifine Stearic acid Anthracene Acetonitrile Oxalic acid dihydrate Benzyl alcohol Tolrestat S-oxide alpha,alpha,alpha-Trifluoro-o-cresol TOLRESTAT 2-(TRIFLUOROMETHYL)ANISOLE N-methylthiobenzamide 1-TRIFLUOROMETHYL-NAPHTHALENE

  • TOLRESTAT
  • TOLRESTAT(FORR&DONLY)
  • Alredase
  • AY-27773
  • Lorestat
  • N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine
  • Aldredase
  • N-[[6-Methoxy-5-(trifluoromethyl)naphthalen-1-yl]thioxomethyl]-N-methylglycine
  • [(6-Methoxy-5-trifluoromethyl-naphthalene-1-carbothioyl)-methyl-amino]-acetic acid
  • 2-(6-Methoxy-N-Methyl-5-(trifluoroMethyl)naphthalene-1-carbothioaMido)acetic acid
  • Tolrestatin
  • TolrestattolrestattolrestatTolrestat
  • CS-148
  • Tolrestat, AY 27773
  • AY-27773;AY 27773; AY27773
  • Glycine, N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-
  • TOLRESTAT USP/EP/BP
  • Inhibitor,inhibit,Tolrestat,AY 27773,Aldose Reductase,AY27773
  • 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid
  • 82964-04-3