1-BOC-5-CYANOINDOLE
- Product Name
- 1-BOC-5-CYANOINDOLE
- CAS No.
- 475102-10-4
- Chemical Name
- 1-BOC-5-CYANOINDOLE
- Synonyms
- N-Boc-5-cyanoindole;1-BOC-5-CYANOINDOLE;1-BOC-5-Cyano-1H-indole;N-(tert-Butoxycarbonyl)-5-cyanoindole;tert-Butyl 5-cyano-1H-indole-1-carboxylate;5-cyano-1-indolecarboxylic acid tert-butyl ester;5-Cyano-indole-1-carboxylic acid tert-butyl ester;1H-Indole-1-carboxylic acid, 5-cyano-, 1,1-dimethylethyl ester;1H-Indole-1-carboxylicacid, 5-cyano-, 1,1-dimethylethyl este...
- CBNumber
- CB2179638
- Molecular Formula
- C14H14N2O2
- Formula Weight
- 242.27
- MOL File
- 475102-10-4.mol
1-BOC-5-CYANOINDOLE Property
- Melting point:
- 128-129 °C(Solv: ethanol (64-17-5); hexane (110-54-3))
- Boiling point:
- 386.4±34.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B201448
- Product name
- 1-BOC-5-cyanoindole
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B201448
- Product name
- 1-BOC-5-cyanoindole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- V6095
- Product name
- 1-BOC-5-cyanoindole
- Packaging
- 5g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- CHM0078805
- Product name
- 1-BOC-5-CYANOINDOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $657.31
- Updated
- 2021/12/16
- Product number
- V6095
- Product name
- 1-BOC-5-cyanoindole
- Packaging
- 25g
- Price
- $384
- Updated
- 2021/12/16
1-BOC-5-CYANOINDOLE Chemical Properties,Usage,Production
Synthesis
15861-24-2
24424-99-5
475102-10-4
In a 100 mL round bottom flask, 5-cyanoindole (2.0 g, 14.07 mmol) was dissolved in 20 mL of anhydrous tetrahydrofuran (THF). To this solution, 4-dimethylaminopyridine (DMAP, 0.86 g, 7.03 mmol) was added and the mixture was stirred for 0.5 h at room temperature. Subsequently, di-tert-butyl dicarbonate (Boc2O, 3.07 g, 14.07 mmol) was added and the reaction continued to be stirred for 2 hours. After completion of the reaction, the reaction was quenched with water and extracted with ether (2×). The organic layers were combined, washed sequentially with 1N hydrochloric acid, water and saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give 1-Boc-5-cyanoindole (3.26 g, 96% yield) as a white solid. The product was characterized by 1H NMR (DMSO-d6): δ 8.20-8.14 (m, 2H), 7.83 (d, 1H), 7.70 (d, 1H), 6.80 (d, 1H), 1.63 (s, 9H).
References
[1] Synthesis, 2009, # 21, p. 3617 - 3632
[2] Journal of Organic Chemistry, 2002, vol. 67, # 21, p. 7551 - 7552
[3] Patent: WO2004/43950, 2004, A1. Location in patent: Page 134
[4] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 54-55
[5] Patent: WO2011/60389, 2011, A1. Location in patent: Page/Page column 98-99
1-BOC-5-CYANOINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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