2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE

Product Name: 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
CAS No.: 218594-15-1
Chemical Name: 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
Synonyms: 2-BROMO-5-BOC-AMINOPYRIDINE;3-(Boc-amino)-6-bromopyridine;tert-butyl 6-bromopyridin-3-ylcarbamate;5-Amino-2-bromopyridine, 5-BOC protected;2-BROMO-5-AMINOPYRIDINE, N-BOC PROTECTED;5-Amino-2-bromopyridine,5-BOCprotected95%;tert-butyl N-(6-broMopyridin-3-yl)carbaMate;2-Bromo-5-aminopyridine, N-BOC protected 95%;2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE;5-Amino-2-bromopyridine, 5-BOC protected 95%
CBNumber: CB2184863
Molecular Formula: C10H13BrN2O2
Formula Weight: 273.13
MOL File: 218594-15-1.mol

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2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE Property

Melting point:: 124-126
Boiling point:: 301.0±27.0 °C(Predicted)
Density: 1.453±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.06±0.70(Predicted)
form: solid
color: White to off-white

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
Hazard Note: Irritant
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T135643
Product name: tert-Butyl6-Bromopyridin-3-ylcarbamate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR5734
Product name: 5-Amino-2-bromopyridine,5-BOCprotected
Purity: 95%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR5734
Product name: 5-Amino-2-bromopyridine,5-BOCprotected
Purity: 95%
Packaging: 250mg
Price: $29
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142359
Product name: tert-Butyl (6-bromopyridin-3-yl)carbamate
Packaging: 1g
Price: $64
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-U8
Product name: 5-Amino-2-bromopyridine, 5-Boc protected
Purity: 95%
Packaging: 1g
Price: $66
Updated: 2021/12/16

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2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE Chemical Properties,Usage,Production

Synthesis

13534-97-9

24424-99-5

218594-15-1

To a solution of 6-bromopyridin-3-amine (5.4 g, 28.9 mmol) in dichloromethane (200 mL) was sequentially added triethylamine (4.4 g, 43.3 mmol) and di-tert-butyl dicarbonate (7.6 g, 34.7 mmol). The reaction mixture was stirred at room temperature for 4 h. After completion of the reaction, the reaction was quenched with water (300 mL). The organic layer was separated and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography with the eluent being a petroleum ether solution of 2-10% ethyl acetate to afford the target product, tert-butyl (6-bromopyridin-3-yl)carbamate, as a colorless solid. Mass spectra (ESI, m/z): 273.1, 275.1 [M + 1]+; 1H NMR (300 MHz, DMSO-d6) δ 9.72 (s, 1H), 8.45 (d, J = 1.8 Hz, 1H), 7.83 (d, J = 5.4 Hz, 1H), 7.53 (d, J = 5.7 Hz, 1H), 1.48 (s, 9H) .

References

[1] Patent: WO2015/188368, 2015, A1. Location in patent: Page/Page column 114
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8709 - 8715
[3] Chemistry - A European Journal, 2010, vol. 16, # 30, p. 9056 - 9067
[4] Patent: WO2017/207813, 2017, A1. Location in patent: Page/Page column 126
[5] Patent: WO2006/92599, 2006, A2. Location in patent: Page/Page column 58-59

2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE Suppliers

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218594-15-1, 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINERelated Search:

Sulfasalazine 2-Bromo-4-(tert-butoxycarbonylamino)pyridine 6-BROMO-2-TERT-BUTOXYCARBONYLAMINO-PYRIDINE 3-(BOC-AMINO)PYRIDINE 2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE 2-(Boc-amino)-5-bromopyridine TERT-BUTYL 1,3-BENZODIOXOL-4-YLCARBAMATE 2-(Boc-aMinoMethyl)pyriMidine

2-BROMO-5-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE

2-BROMO-5-AMINOPYRIDINE, N-BOC PROTECTED

2-BROMO-5-BOC-AMINOPYRIDINE

2-Bromo-5-aminopyridine, N-BOC protected 95%

tert-butyl 6-bromopyridin-3-ylcarbamate

5-Amino-2-bromopyridine, 5-BOC protected 95%

tert-butyl N-(6-broMopyridin-3-yl)carbaMate

(6-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

5-Amino-2-bromopyridine,5-BOCprotected95%

5-amino-6-bromo-3-pyridinecarboxylic acid tert-butyl ester

5-Amino-2-bromopyridine, 5-BOC protected

Carbamic acid, N-(6-bromo-3-pyridinyl)-, 1,1-dimethylethyl ester

3-(Boc-amino)-6-bromopyridine

218594-15-1

Amines

blocks

Bromides

Pyridines

Pyridine