(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 433711-95-6
Chemical Name: (2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: Zinc02511835;(2-BROMO-PYRIDIN-4-Y;2-BROMO-4-BOC PYRIDINE;2-Bromo-4-N-Boc-aminopyridine;4-(BOC-AMINO)-2-BROMOPYRIDINE;N-Boc-4-amino-2-bromopyridine;2-Bromo-N-Boc-pyridin-4-amine;Tert-butyl 2-bromopyridin-4-ylcarbamate;tert-butyl N-(2-broMopyridin-4-yl)carbaMate;2-Bromo-4-(tert-butoxycarbonylamino)pyridine
CBNumber: CB4125543
Molecular Formula: C10H13BrN2O2
Formula Weight: 273.13
MOL File: 433711-95-6.mol

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(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:: 299.3±25.0 °C(Predicted)
Density: 1.453±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.97±0.70(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 433711-95-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000209
Product name: (2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Purity: Aldrich
Packaging: 1g
Price: $201
Updated: 2023/06/20

Matrix Scientific

Product number: 018201
Product name: (2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: Y2988
Product name: tert-Butyl2-bromopyridine-4-carboxylate
Packaging: 1g
Price: $117
Updated: 2021/12/16

Matrix Scientific

Product number: 018201
Product name: (2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Packaging: 5g
Price: $149
Updated: 2021/12/16

Matrix Scientific

Product number: 018201
Product name: (2-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Packaging: 10g
Price: $247
Updated: 2021/12/16

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(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

7598-35-8

24424-99-5

433711-95-6

General procedure for the synthesis of 4-tert-butoxycarbonylamino-2-bromopyridine from 4-amino-2-bromopyridine and di-tert-butyl dicarbonate: 2-bromopyridin-4-amine (100.0 g), triethylamine (Et3N, 64.8 g), and dichloromethane (DCM, 1.0 L) were added to the reaction vial and the reaction mixture was stirred for 15-30 min at 20-30 °C. Subsequently, 4-dimethylaminopyridine (DMAP, 3.5 g) was added to the reaction vial and di-tert-butyl dicarbonate ((Boc)2O, 416.3 g) was added slowly and dropwise. The reaction mixture was stirred continuously at 20-30 °C for 16 h, during which the progress of the reaction was monitored by HPLC. After completion of the reaction, the reaction mixture was washed with deionized water (2 L). The organic phase was separated and concentrated under reduced pressure to give the crude product as a yellow solid. The solid was stirred with methanol (MeOH, 300.0 mL) at 20-30 °C for 30 min and then filtered to give 4-tert-butoxycarbonylamino-2-bromopyridine (171.2 g) as an off-white solid.

References

[1] Dalton Transactions, 2016, vol. 45, # 32, p. 12807 - 12813
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8709 - 8715
[3] Patent: US2003/119847, 2003, A1
[4] Patent: WO2017/137535, 2017, A1. Location in patent: Page/Page column 105

(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 78 Germany 2 India 1 United Kingdom 2 United States 14 Global 97

J & K SCIENTIFIC LTD.

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View Lastest Price from (2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Dideu Industries Group Limited

Product: (2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER 433711-95-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Bromo-4-N-Boc-aminopyridine 433711-95-6
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

Career Henan Chemical Co

Product: 2-Bromo-4-boc pyridine 433711-95-6
Price: US $10.00-100.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-03-06

433711-95-6, (2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

2-Azaspiro[3.4]octane-2-carboxylic acid, 1,1-dimethylethyl ester Pyrazolo[1,5-a]pyrazine-5(4H)-carboxylic acid, 2-formyl-6,7-dihydro-, 1,1-dimethylethyl ester Tert-Butyl2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate 2-Chloropyridine-4-carboxylic acid tert-butyl ester Tert-Butyl 2-Iodo-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate(WX141846) 4H-Pyrazolo[1,5-a][1,4]diazepine-5(6H)-carboxylic acid, 2-formyl-7,8-dihydro-, 1,1-dimethylethyl ester tert-butyl 2-bromo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate 2-(Boc-amino)-5-bromopyridine (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER 3-BOCAMINO-4-BROMOPYRIDINE 4-(Boc-amino)pyridine (2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER 4-Amino-2-bromopyridine

4-(BOC-AMINO)-2-BROMOPYRIDINE

2-BROMO-4-BOC PYRIDINE

(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER

2-Bromo-4-(tert-butoxycarbonylamino)pyridine

N-Boc-4-amino-2-bromopyridine

Tert-butyl 2-bromopyridin-4-ylcarbamate

Zinc02511835

tert-butyl N-(2-broMopyridin-4-yl)carbaMate

(2-BROMO-PYRIDIN-4-Y

2-Bromo-4-N-Boc-aminopyridine

N-(2-bromo-4-pyridinyl)carbamic acid tert-butyl ester

Carbamic acid, N-(2-bromo-4-pyridinyl)-, 1,1-dimethylethyl ester

(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH

2-Bromo-N-Boc-pyridin-4-amine

433711-95-6

Heterocycle-Pyridine series