(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- Product Name
- (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS No.
- 116026-98-3
- Chemical Name
- (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- Synonyms
- Zinc04352714;3-(BOC-AMINO)-2-BROMOPYRIDINE;2-BROMO-3-N-BOC-AMINOPYRIDINE;TERT-BUTYL 2-BROMOPYRIDIN-3-YLCARBAMATE;tert-butyl N-(2-broMopyridin-3-yl)carbaMate;tert-Butyl 2-bromopyridin-3-ylcarbamate ,97%;2-bromo-3-[N-(t-butyloxycarbonylamino]pyridine;2-Bromo-3[N-（tert-butyloxycar-bonyl)amino]pyridine;N-(2-bromo-3-pyridinyl)carbamic acid tert-butyl ester;(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CBNumber
- CB8704971
- Molecular Formula
- C10H13BrN2O2
- Formula Weight
- 273.13
- MOL File
- 116026-98-3.mol
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property
- Melting point:
- 84-85°C
- Boiling point:
- 298.9±25.0 °C(Predicted)
- Density
- 1.453±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 12.00±0.70(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000357
- Product name
- (2-Bromo-pyridin-3-yl)-carbamic acid tert-butyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $497
- Updated
- 2025/07/31
- Product number
- T204853
- Product name
- tert-Butyl2-Bromopyridin-3-ylcarbamate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T204853
- Product name
- tert-Butyl2-Bromopyridin-3-ylcarbamate
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 023790
- Product name
- (2-Bromo-pyridin-3-yl)-carbamic acidtert-butyl ester
- Purity
- 97%
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 023790
- Product name
- (2-Bromo-pyridin-3-yl)-carbamic acidtert-butyl ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
39856-58-1
24424-99-5
116026-98-3
Step 1: Synthesis of tert-butyl 2-bromopyridin-3-ylcarbamate (10a) To a solution of 2-bromopyridin-3-amine (3.0 g, 17.3 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added lithium bis(trimethylsilyl)carbamate (1M, 35 mL, 35 mmol) at 0 °C. The reaction mixture was stirred at this temperature for 30 minutes. Subsequently, a solution of di-tert-butyl dicarbonate (Boc2O, 3.9 g, 17.3 mmol) in THF (20 mL) was added and the mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction mixture was poured into 0.1 M hydrochloric acid (HCl) and extracted with ethyl acetate (EA). The organic layers were combined, washed with saturated saline (brine), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (CC, petroleum ether/ethyl acetate = 5/1) to afford the target compound 10a (2.9 g, 62% yield) as a white solid.
References
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 16, p. 5032 - 5043
[2] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 51
[3] Patent: US2013/131036, 2013, A1. Location in patent: Paragraph 1676; 1677
[4] Patent: WO2013/62966, 2013, A2. Location in patent: Paragraph 203; 204
[5] Patent: WO2005/21529, 2005, A1. Location in patent: Page/Page column 31
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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