(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 257937-08-9
Chemical Name: (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: 4-BOCAMINO-3-BROMOPYRIDINE;N-Boc-4-amino-3-bromopyridine;tert-Butyl (3-broMopyridin-4-yl)carbaMate;ert-butylN-(3-bromopyridin-4-yl)carbamate;tert-butyl N-(3-bromo-4-pyridyl)carbamate;tert-butyl N-(3-bromopyridin-4-yl)carbamate;N-(3-bromo-4-pyridinyl)carbamic acid tert-butyl ester;(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER;(3-BROMOPYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%;Carbamic acid, N-(3-bromo-4-pyridinyl)-, 1,1-dimethylethyl ester
CBNumber: CB6325277
Molecular Formula: C10H13BrN2O2
Formula Weight: 273.13
MOL File: 257937-08-9.mol

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(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:: 286.1±25.0 °C(Predicted)
Density: 1.453±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 11.71±0.70(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B695360
Product name: tert-Butyl(3-Bromopyridin-4-yl)carbamate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51545
Product name: (3-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: W4915
Product name: (3-Bromopyridin-4-yl)carbamicacidtert-butylester
Packaging: 250mg
Price: $88
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51545
Product name: (3-Bromo-pyridin-4-yl)carbamic acid tert-butyl ester
Packaging: 1g
Price: $164.9
Updated: 2021/12/16

Matrix Scientific

Product number: 071914
Product name: (3-Bromopyridin-4-yl)carbamic acidtert-butyl ester
Purity: 95+%
Packaging: 1g
Price: $231
Updated: 2021/12/16

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(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

13534-98-0

24424-99-5

257937-08-9

In a dry reaction flask, 4-amino-3-bromopyridine (10.0 g, 57.803 mmol) was dissolved in tetrahydrofuran (THF, 500 mL), and triethylamine (8.8 g, 86.705 mmol) and di-tert-butyl dicarbonate (Boc anhydride, 37.89 g, 173.410 mmol) were added sequentially under stirring. The reaction mixture was stirred continuously for 2 hours at room temperature. After completion of the reaction, the mixture was poured into water (700 mL) and extracted with ethyl acetate (EtOAc, 500 mL x 2). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography to afford tert-butyl (3-bromopyridin-4-yl)carbamate (37.0 g, 136.029 mmol) in a calculated yield based on 4-amino-3-bromopyridine. Mass spectrometry (MS) analysis showed a molecular ion peak of 274.95 (M + 2).

References

[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 39, p. 11859 - 11862
[2] Angew. Chem., 2016, vol. 128, p. 12038 - 12041,4
[3] Patent: US2006/46983, 2006, A1. Location in patent: Page/Page column 186
[4] Patent: WO2018/69468, 2018, A1. Location in patent: Page/Page column 76

(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Silica gel Hexane Nitrogen tert-Butyllithium Di-tert-butyl dicarbonate Triethylamine 1,2-Dibromoethane Tetrahydrofuran Ethyl acetate Dichloromethane 4-Aminopyridine

Preparation Products

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(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 77 India 1 United Kingdom 2 United States 11 Global 91

Shanghai Sunway Pharmaceutical Technology Co., Ltd

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View Lastest Price from (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Dideu Industries Group Limited

Product: (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 257937-08-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: (3-Bromopyridin-4-yl)carbamic acid tert-butyl ester 257937-08-9
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

257937-08-9, (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

BOC-2,3-DIMETHYLANILINE tert-butyl N-(3-fluoro-4-methoxyphenyl)carbamate TERT-BUTYL-4-METHOXYCARBANILATE 4-FLUOROANILINE, N-BOC PROTECTED (3,4-difluorophenyl)-carbamic acid-tert-butyl ester 2-(BOC-Amino)-4-methylphenylboronic acid,pinacol (3-Bromo-2-methyl-phenyl)-carbamic acid tert-butyl ester tert-butyl (3-chloro-5-methylphenyl)carbamate Tert-butyl (2-bromo-4-butylphenyl)carbamate Tert-butyl (4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)carbamate tert-butyl (2,5-dichloro-3-methylphenyl)carbamate Carbamic acid, N-(5-bromo-2-methoxyphenyl)-, 1,1-dimethylethyl ester tert-butyl (2-bromo-6-fluoro-3-methylphenyl)carbamate 1-N-BOC-3-FLUORO-ANILINE Tert-butyl (2-bromo-4,6-difluorophenyl)carbamate Carbamic acid, (4-bromo-3,5-dimethoxyphenyl)-, 1,1-dimethylethyl ester (9CI) BOC-2,4-DIMETHYLANILINE INDEX NAME NOT YET ASSIGNED

4-BOCAMINO-3-BROMOPYRIDINE

(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(3-BROMOPYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%

tert-Butyl (3-broMopyridin-4-yl)carbaMate

N-Boc-4-amino-3-bromopyridine

tert-butyl N-(3-bromo-4-pyridyl)carbamate

N-(3-bromo-4-pyridinyl)carbamic acid tert-butyl ester

Carbamic acid, N-(3-bromo-4-pyridinyl)-, 1,1-dimethylethyl ester

ert-butylN-(3-bromopyridin-4-yl)carbamate

(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH

tert-butyl N-(3-bromopyridin-4-yl)carbamate

257937-08-9

API intermediates