ChemicalBook > CAS DataBase List > (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.
116026-98-3
Chemical Name
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms
Zinc04352714;3-(BOC-AMINO)-2-BROMOPYRIDINE;2-BROMO-3-N-BOC-AMINOPYRIDINE;TERT-BUTYL 2-BROMOPYRIDIN-3-YLCARBAMATE;tert-butyl N-(2-broMopyridin-3-yl)carbaMate;tert-Butyl 2-bromopyridin-3-ylcarbamate ,97%;2-bromo-3-[N-(t-butyloxycarbonylamino]pyridine;2-Bromo-3[N-（tert-butyloxycar-bonyl)amino]pyridine;N-(2-bromo-3-pyridinyl)carbamic acid tert-butyl ester;(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CBNumber
CB8704971
Molecular Formula
C10H13BrN2O2
Formula Weight
273.13
MOL File
116026-98-3.mol
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(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:
84-85°C
Boiling point:
298.9±25.0 °C(Predicted)
Density 
1.453±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
12.00±0.70(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000357
Product name
(2-Bromo-pyridin-3-yl)-carbamic acid tert-butyl ester
Purity
Aldrich
Packaging
1g
Price
$497
Updated
2025/07/31
TRC
Product number
T204853
Product name
tert-Butyl2-Bromopyridin-3-ylcarbamate
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
T204853
Product name
tert-Butyl2-Bromopyridin-3-ylcarbamate
Packaging
500mg
Price
$285
Updated
2021/12/16
Matrix Scientific
Product number
023790
Product name
(2-Bromo-pyridin-3-yl)-carbamic acidtert-butyl ester
Purity
97%
Packaging
250mg
Price
$73
Updated
2021/12/16
Matrix Scientific
Product number
023790
Product name
(2-Bromo-pyridin-3-yl)-carbamic acidtert-butyl ester
Purity
97%
Packaging
1g
Price
$184
Updated
2021/12/16
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(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

39856-58-1

24424-99-5

116026-98-3

Step 1: Synthesis of tert-butyl 2-bromopyridin-3-ylcarbamate (10a) To a solution of 2-bromopyridin-3-amine (3.0 g, 17.3 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added lithium bis(trimethylsilyl)carbamate (1M, 35 mL, 35 mmol) at 0 °C. The reaction mixture was stirred at this temperature for 30 minutes. Subsequently, a solution of di-tert-butyl dicarbonate (Boc2O, 3.9 g, 17.3 mmol) in THF (20 mL) was added and the mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction mixture was poured into 0.1 M hydrochloric acid (HCl) and extracted with ethyl acetate (EA). The organic layers were combined, washed with saturated saline (brine), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (CC, petroleum ether/ethyl acetate = 5/1) to afford the target compound 10a (2.9 g, 62% yield) as a white solid.

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 16, p. 5032 - 5043
[2] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 51
[3] Patent: US2013/131036, 2013, A1. Location in patent: Paragraph 1676; 1677
[4] Patent: WO2013/62966, 2013, A2. Location in patent: Paragraph 203; 204
[5] Patent: WO2005/21529, 2005, A1. Location in patent: Page/Page column 31

(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Diphenylphosphoryl azide tert-Butanol Triethylamine Chloroform Ethyl acetate Potassium permanganate 2-Bromo-3-methylpyridine

Preparation Products

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(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

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116026-98-3, (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER (2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER 3-(BOC-AMINO)PYRIDINE

  • TERT-BUTYL 2-BROMOPYRIDIN-3-YLCARBAMATE
  • (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
  • (2-BROMO-3-PYRIDINYL)CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER
  • 2-BROMO-3-N-BOC-AMINOPYRIDINE
  • tert-Butyl 2-bromopyridin-3-ylcarbamate ,97%
  • 2-Bromo-3[N-（tert-butyloxycar-bonyl)amino]pyridine
  • Zinc04352714
  • tert-butyl N-(2-broMopyridin-3-yl)carbaMate
  • 3-(BOC-AMINO)-2-BROMOPYRIDINE
  • 2-bromo-3-[N-(t-butyloxycarbonylamino]pyridine
  • N-(2-bromo-3-pyridinyl)carbamic acid tert-butyl ester
  • Carbamic acid, N-(2-bromo-3-pyridinyl)-, 1,1-dimethylethyl ester
  • (2-<WBR>Bromo-<WBR>pyridin-<WBR>3-<WBR>yl)<WBR>-<WBR>carbamic acid tert-butyl ester
  • 116026-98-3
  • C10H13BrN2O2