2-Chloropyridine-4-carboxylic acid tert-butyl ester
Uses- Product Name
- 2-Chloropyridine-4-carboxylic acid tert-butyl ester
- CAS No.
- 295349-62-1
- Chemical Name
- 2-Chloropyridine-4-carboxylic acid tert-butyl ester
- Synonyms
- Methyl 2-Chloroisonicotite;2-Chloropyridine-4-carbox...;tert-butyl 2-chloroisonicotinate;2-CHLOROISONICOTINIC ACID T-BUTYL ESTER;2-CHLORO-4-PYRIDINECARBOXYLIC ACID1,1-D;ert-butyl2-chloropyridine-4-carboxylate;tert-Butyl 2-chloropyridine-4-carboxylate;2-CHLOROISONICOTINIC ACID TERT-BUTYL ESTER;2-Chloro-4-pyridinecaroboxylic acid methyl ester;2-Chloro-4-pyridinecarboxylic acid tert-butyl ester
- CBNumber
- CB8192031
- Molecular Formula
- C10H12ClNO2
- Formula Weight
- 213.66
- MOL File
- 295349-62-1.mol
2-Chloropyridine-4-carboxylic acid tert-butyl ester Property
- Boiling point:
- 287.4±20.0 °C(Predicted)
- Density
- 1.173±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.27±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 295349-62-1(CAS DataBase Reference)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809688
- Product name
- tert-Butyl2-Chloropyridine-4-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 068877
- Product name
- tert-Butyl 2-chloropyridine-4-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 068877
- Product name
- tert-Butyl 2-chloropyridine-4-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4H23-5-36
- Product name
- tert-Butyl 2-chloropyridine-4-carboxylate
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC152085
- Product name
- 2-Chloro-4-pyridinecarboxylic acid 1,1-dimethylethylester
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
2-Chloropyridine-4-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Uses
2-Chloroisonicotinic acid tert-butyl ester is a useful research chemical for organic synthesis and other chemical processes.
Synthesis
6313-54-8
36805-97-7
295349-62-1
General procedure for the synthesis of tert-butyl 2-chloroisonicotinate from 2-chloroisonicotinic acid and N,N-dimethylformamide di-tert-butyl acetal: 10.0 g (63.4 mmol) of 2-chloroisonicotinic acid was dissolved in 100 ml of chloroform and heated to reflux temperature. A total of 91.2 ml (380 mmol, 6 eq.) of N,N-dimethylformamide di-tert-butyl acetal was added in three additions of 30.4 ml each at the beginning of the reaction, after 1 h and after 2 h. Upon completion of the reaction, it was cooled down to room temperature, and the reaction mixture was diluted with ethyl acetate, washed with water, sodium bicarbonate solution, and saturated saline in that order, and dried over anhydrous sodium sulfate. The residue was purified by silica gel column chromatography (fast column chromatography, eluent gradient from hexane to hexane/ethyl acetate 95/5) to give 7.6 g (35.6 mmol, 56% yield) of white solid product. Mass spectrum (LC/MS): m/z 158 = [M + H - tBu]+. 1H-NMR (300 MHz, CDCl3): δ 8.55 (d, 1H), 7.85 (s, 1H), 7.76 (d, 1H), 1.64 (s, 9H).
References
[1] Patent: US2008/132477, 2008, A1. Location in patent: Page/Page column 28
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 1, p. 110 - 130
[3] Patent: WO2014/141171, 2014, A1. Location in patent: Page/Page column 17; 18
2-Chloropyridine-4-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloropyridine-4-carboxylic acid tert-butyl ester manufacturers
- Product
- 2-Chloropyridine-4-carboxylic acid tert-butyl ester 295349-62-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 830
- Release date
- 2019-09-02