LATRUNCULIN B

Product Name: LATRUNCULIN B
CAS No.: 76343-94-7
Chemical Name: LATRUNCULIN B
Synonyms: LAT-B;NSC 339663;LATRUNCULIN B;LATRUNCULIN B, LUTRUNCULIA MAGNIFICA;LatrunculinBfromLutrunculiamagnifica;LATRUNCULIN B, LATRUNCULIA MAGNIFICA;Latrunculin B from Latruncula magnifica;Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem;(4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone;2-Thiazolidinone, 4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-, (4R)-
CBNumber: CB2186645
Molecular Formula: C20H29NO5S
Formula Weight: 395.51
MOL File: 76343-94-7.mol

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LATRUNCULIN B Property

alpha: D24 +112° (c = 0.48 in chloroform)
storage temp.: -20°C
solubility: DMSO: soluble
form: solid
color: light yellow
optical activity: +120.123 （CHCl3）
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 428020
Product name: Latrunculin B,
Packaging: 1mg
Price: $251
Updated: 2024/03/01

Sigma-Aldrich

Product number: 428020
Product name: Latrunculin B,
Packaging: 5mg
Price: $733
Updated: 2024/03/01

Cayman Chemical

Product number: 10010631
Product name: Latrunculin B
Purity: ≥97%
Packaging: 1 mg
Price: $219
Updated: 2024/03/01

Cayman Chemical

Product number: 10010631
Product name: Latrunculin B
Purity: ≥97%
Packaging: 50μg
Price: $27
Updated: 2022/04/27

Cayman Chemical

Product number: 10010631
Product name: Latrunculin B
Purity: ≥97%
Packaging: 100μg
Price: $51
Updated: 2022/04/27

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LATRUNCULIN B Chemical Properties,Usage,Production

Description

Latrunculin B (76343-94-7) inhibits actin polymerization and disrupts microfilament organization.1 Significantly more potent than cytochalasins in the disruption of microfilament mediated processes2, causes shortening and thickening of stress fibers. Active in cell culture.3,4?Effective doses for latrunculin B vary depending upon cell type but are frequently in the low micromolar range. Note: Latrunculin B is slowly inactivated by fetal bovine serum.

Uses

In elucidation of molecular mechanisms of motile processes.

Uses

Latrunculin B is an actin polymerization inhibitor.

Uses

Latrunculin B from Latruncula magnifica has been used for actin depolymerisation in various experiments. It has also been used as a component in bone marrow-derived dendritic cell (BMDC) complete medium, to study the formation of tubules from phagosomes in dendritic cells.

Definition

ChEBI: A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.

General Description

Latrunculin B is a macrocyclic toxin, which is produced by Latruncula magnifica.

Biochem/physiol Actions

Primary TargetActin polymerization

storage

Store at -20°C

References

1) Coue?et al. (1987),?Inhibition of actin polymerization by latrunculin; FEBS Lett.,?213?316 2) Spector?et al. (1989),?Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth; Cell Motil. Cytoskeleton,?13?127 3) Wakatsuki?et al. (2001),?Effects of cytochalasin D and latrunculin B on mechanical properties of cells; J. Cell. Sci.,?114?1025 4) Cha?et al. (2004),?The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2 but is dependent on an intact actin cytoskeleton as determined by FRAP; Prog. Clin. Biol. Res.,?230 4 5) Herrera (2021), Cell cultures, transfection and treatments. protocols.io???https://dx.doi.org/10.17504/protocols.io.77ehrje [Focus Citation]

LATRUNCULIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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LATRUNCULIN B Suppliers

China 42 Germany 1 Japan 2 Switzerland 2 United Kingdom 6 United States 16 USA 1 Global 70

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LATRUNCULIN B

LATRUNCULIN B, LATRUNCULIA MAGNIFICA

LAT-B

LatrunculinBfromLutrunculiamagnifica

LATRUNCULIN B, LUTRUNCULIA MAGNIFICA

NSC 339663

(4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone

Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem

Latrunculin B from Latruncula magnifica

(4R)-4-[(1R,4S,5Z,9Z,13R,15R)-15-hydroxy-4,9-dimethyl-11-oxo-12,16-dioxabicyclo[11.3.1]heptadeca-5,9-dien-15-yl]-1,3-thiazolidin-2-one

2-Thiazolidinone, 4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-, (4R)-

76343-94-7

C20H29NSO5

C20H29NO5S

Cytoskeleton and Extracellular Matrix

BioChemical

Actin Inhibitors and Probes

Cell Signaling and Neuroscience

Cell Biology