2-AMINO-N-METHYLBENZENESULFONAMIDE
- Product Name
- 2-AMINO-N-METHYLBENZENESULFONAMIDE
- CAS No.
- 16288-77-0
- Chemical Name
- 2-AMINO-N-METHYLBENZENESULFONAMIDE
- Synonyms
- N-Methyl-2-aminobenzenesulfonamide;2-AMINO-N-METHYLBENZENESULFONAMIDE;BenzenesulfonaMide, 2-aMino-N-Methyl-;2-aMino-N-Methylbenzene-1-sulfonaMide;2-amino-N-methylbenzenesulfonamide(SALTDATA: HCl)
- CBNumber
- CB2191047
- Molecular Formula
- C7H10N2O2S
- Formula Weight
- 186.23
- MOL File
- 16288-77-0.mol
2-AMINO-N-METHYLBENZENESULFONAMIDE Property
- Melting point:
- 59-60℃
- Boiling point:
- 352.9±44.0 °C(Predicted)
- Density
- 1.308
- storage temp.
- 2-8°C(protect from light)
- pka
- 11?+-.0.10(Predicted)
- Appearance
- Light yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A634700
- Product name
- 2-Amino-N-methylbenzenesulfonamide
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA153547
- Product name
- 2-Amino-N-methylbenzenesulfonamide
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-M2487
- Product name
- Benzenesulfonamide,2-amino-N-methyl-
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FA153547
- Product name
- 2-Amino-N-methylbenzenesulfonamide
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- W3551
- Product name
- 2-Amino-N-methylbenzenesulfonamide
- Packaging
- 5g
- Price
- $169
- Updated
- 2021/12/16
2-AMINO-N-METHYLBENZENESULFONAMIDE Chemical Properties,Usage,Production
Description
2-Amino-N-methylbenzenesulfonamide is obtained by treating 2-nitrobenzenesulfonyl chloride with methylamine and subsequent reduction. Used as a dye component. The amides of 2-aminobenzenesulfonic acid can be treated with aldehydes or orthoformic acid esters to give 1,2,4-benzothiadiazine 1,1-dioxides or their dihydro compounds; these substances have been proposed as diuretics.
Synthesis
23530-40-7
16288-77-0
Step B / Intermediate C4: Synthesis of 2-amino-N-methylbenzenesulfonamide To a solution of N-methyl-2-nitrobenzenesulfonamide (26 g, 0.12 mol) in methanol (500 mL) was added 10% palladium carbon catalyst (2 g). The reaction mixture was stirred at room temperature under hydrogen atmosphere for 3 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 2-amino-N-methylbenzenesulfonamide (22 g, 98% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.45-7.48 (dd, 1H, J=1.6 Hz, 8.0 Hz), 7.24-7.31 (m, 2H), 6.81-6.83 (dd, 1H, J=0.6 Hz, 8.0 Hz), 6.60-6.65 (m, 1H), 5.89 (s 2H), 2.370-2.374 (d, 3H, J=1.6Hz).
References
[1] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 64
[2] Angewandte Chemie - International Edition, 2010, vol. 49, # 29, p. 4955 - 4957
[3] Patent: WO2007/45868, 2007, A1. Location in patent: Page/Page column 47
[4] Farmaco, Edizione Scientifica, 1954, vol. 9, p. 661,678, 680
[5] Farmaco, Edizione Scientifica, 1957, vol. 12, p. 495,499, 500
2-AMINO-N-METHYLBENZENESULFONAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-N-METHYLBENZENESULFONAMIDE Suppliers
- Tel
- --
- Fax
- --
- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from 2-AMINO-N-METHYLBENZENESULFONAMIDE manufacturers
- Product
- 2-AMINO-N-METHYLBENZENESULFONAMIDE 16288-77-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10