BENZTHIAZIDE
- Product Name
- BENZTHIAZIDE
- CAS No.
- 91-33-8
- Chemical Name
- BENZTHIAZIDE
- Synonyms
- Exna;exva;p1393;Urese;Diucen;Edemex;fouane;Fovane;P 1393;Exsalt
- CBNumber
- CB9758542
- Molecular Formula
- C15H14ClN3O4S3
- Formula Weight
- 431.94
- MOL File
- 91-33-8.mol
BENZTHIAZIDE Property
- Melting point:
- 231-232° (U.S. patent); mp 238-239° (P'an)
- Boiling point:
- 680.6±65.0 °C(Predicted)
- Density
- 1.4176 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.57±0.20(Predicted)
- color
- White to Off-White
- Water Solubility
- 2.8mg/L(room temperature)
- EPA Substance Registry System
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide (91-33-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 42/43
- Safety Statements
- 26-36
- WGK Germany
- 2
- RTECS
- DK8400000
- Hazardous Substances Data
- 91-33-8(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (P'an)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B7149
- Product name
- Benzthiazide
- Packaging
- 1g
- Price
- $23.76
- Updated
- 2024/03/01
- Product number
- B209925
- Product name
- Benzthiazide
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 262276
- Product name
- Benzthiazide
- Packaging
- 50mg
- Price
- $419
- Updated
- 2021/12/16
- Product number
- 63107
- Product name
- Benzthiazide
- Packaging
- 100mg
- Price
- $620
- Updated
- 2021/12/16
- Product number
- API0008565
- Product name
- BENZTHIAZIDE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $716.1
- Updated
- 2021/12/16
BENZTHIAZIDE Chemical Properties,Usage,Production
Originator
Exna,Robins,US,1960
Uses
Benzthiazide is a diuretic, antihypertensive agent.
Definition
ChEBI: 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.
Manufacturing Process
The preparation of the dihydro analog is as follows:
(A) Preparation of 3-Chloromethyl-6-Chloro-7-Sulfamyl-3,4-DihydroBenzothiadizine-1,1-Dioxide - To 8 ml of 40-50% chloroacetaldehyde aqueous
solution and 7 ml of dimethylformamide are added 10 grams of 2,4-
disulfamyl-5-chloroaniline. The mixture is heated on a steam bath for 2 hours
after which it is concentrated at reduced pressure. The residue is triturated
with water. The solid material is recrystallized from methanol-ether after
treatment with activated carbon to give 7.2 grams of product, MP 229°-
230°C.
(B) Preparation of Benzylthiomethyl-6-Chloro-7-Sulfamyl-3,4-
Dihydrobenzothiadiazine-1,1-Dioxide - A mixture of 3-(chloromethyl)-6-chloro-
7-sulfamyl-3,4-dihydrobenzothiadiazine-1,1-dioxide (0.02 mol) and
benzylmercaptan (0.024 mol) in 20 ml of 10% sodium hydroxide and 20 ml of
dimethylformamide is stirred at room temperature for 6 hours. After heating
for 10 minutes on a steam bath, the mixture is cooled and acidified with 6 N
HCl. The product, after recrystallization from acetone, melts at 210°-211°C.
brand name
Aquatag (Solvay Pharmaceuticals); Fovane (Pfizer).
Therapeutic Function
Diuretic, Antihypertensive
Safety Profile
Poison by intravenous route. Adiuretic and antihypertensive agent. When heated todecomposition it emits very toxic fumes of SOx, NOx, andCl-.
BENZTHIAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BENZTHIAZIDE Suppliers
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View Lastest Price from BENZTHIAZIDE manufacturers
- Product
- Benzthiazide 91-33-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- BENZTHIAZIDE 91-33-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-08