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BENZTHIAZIDE

Product Name
BENZTHIAZIDE
CAS No.
91-33-8
Chemical Name
BENZTHIAZIDE
Synonyms
Exna;exva;p1393;Urese;Diucen;Edemex;fouane;Fovane;P 1393;Exsalt
CBNumber
CB9758542
Molecular Formula
C15H14ClN3O4S3
Formula Weight
431.94
MOL File
91-33-8.mol
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BENZTHIAZIDE Property

Melting point:
231-232° (U.S. patent); mp 238-239° (P'an)
Boiling point:
680.6±65.0 °C(Predicted)
Density 
1.4176 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.57±0.20(Predicted)
color 
White to Off-White
Water Solubility 
2.8mg/L(room temperature)
EPA Substance Registry System
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide (91-33-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
26-36
WGK Germany 
2
RTECS 
DK8400000
Hazardous Substances Data
91-33-8(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (P'an)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B7149
Product name
Benzthiazide
Packaging
1g
Price
$38.76
Updated
2025/07/31
TRC
Product number
B209925
Product name
Benzthiazide
Packaging
500mg
Price
$75
Updated
2021/12/16
Usbiological
Product number
262276
Product name
Benzthiazide
Packaging
50mg
Price
$419
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
63107
Product name
Benzthiazide
Packaging
100mg
Price
$620
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008565
Product name
BENZTHIAZIDE
Purity
95.00%
Packaging
100MG
Price
$716.1
Updated
2021/12/16
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BENZTHIAZIDE Chemical Properties,Usage,Production

Originator

Exna,Robins,US,1960

Uses

Benzthiazide is a diuretic, antihypertensive agent.

Definition

ChEBI: 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.

Manufacturing Process

The preparation of the dihydro analog is as follows:
(A) Preparation of 3-Chloromethyl-6-Chloro-7-Sulfamyl-3,4-DihydroBenzothiadizine-1,1-Dioxide - To 8 ml of 40-50% chloroacetaldehyde aqueous solution and 7 ml of dimethylformamide are added 10 grams of 2,4- disulfamyl-5-chloroaniline. The mixture is heated on a steam bath for 2 hours after which it is concentrated at reduced pressure. The residue is triturated with water. The solid material is recrystallized from methanol-ether after treatment with activated carbon to give 7.2 grams of product, MP 229°- 230°C.
(B) Preparation of Benzylthiomethyl-6-Chloro-7-Sulfamyl-3,4- Dihydrobenzothiadiazine-1,1-Dioxide - A mixture of 3-(chloromethyl)-6-chloro- 7-sulfamyl-3,4-dihydrobenzothiadiazine-1,1-dioxide (0.02 mol) and benzylmercaptan (0.024 mol) in 20 ml of 10% sodium hydroxide and 20 ml of dimethylformamide is stirred at room temperature for 6 hours. After heating for 10 minutes on a steam bath, the mixture is cooled and acidified with 6 N HCl. The product, after recrystallization from acetone, melts at 210°-211°C.

brand name

Aquatag (Solvay Pharmaceuticals); Fovane (Pfizer).

Therapeutic Function

Diuretic, Antihypertensive

Safety Profile

Poison by intravenous route. Adiuretic and antihypertensive agent. When heated todecomposition it emits very toxic fumes of SOx, NOx, andCl-.

BENZTHIAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BENZTHIAZIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Benzthiazide 91-33-8
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08

91-33-8, BENZTHIAZIDERelated Search:

Xylazine Hydrochloride hydrobentizide Xylazine Chlorothiazide 2-(BENZYLTHIO)ETHYLAMINE HYDROCHLORIDE 4-Chloro-N-methylbenzenesulphonamide 4-CHLORO-1,3-BENZENEDITHIOL CLOFENAMIDE 4-Amino-6-chlorobenzene-1,3-disulfonamide 2-METHYLSULFANYL-ACETAMIDINE 2-AMINO-N-METHYLBENZENESULFONAMIDE 2H-1,2,4-Benzothiadiazine 1,1-dioxide 2-Aminobenzenesulfonamide BENZTHIAZIDE

  • 6-Chloro-3-[[(phenylMethyl)thio]Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide
  • ((benzylthio)methyl)-3chloro-6dioxyde-1,1sulfonamide-7benzothiadiazine-1,2,
  • -1,-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide
  • 2h-1,2,4-benzothiadiazine-7-sulfonamide,3-((benzylthio)menthyl)-6-chloro-,1,1
  • 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(((phenylmethyl)thio)methyl
  • 3-((Benzylthio)methyl)-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 3-((benzylthio)methyl)-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio
  • 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 3-[(benzylthio)methyl]-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio
  • 3-[(benzylthio)methyl]-6-chloro-7-sulfamoyl-2h-benzo-1,2,4-thiadiazine1,1-diox
  • 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 3-benzylthiomethyl-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxi
  • 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
  • 3-benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide
  • 4-benzothiadiazine-7-sulfonamide,3-((benzylthio)methyl)-6-chloro-,1,1-2h-2
  • 4or6-chloro-2-phenylphenol
  • 6-chloro-3-(((phenylmethyl)thio)methyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide
  • 6-chloro-3-[[(phenylmethyl)thio]methyl]-2h-1,2,4-benzothiadiazine-7-sulfonamid
  • 6-chloro-7-sulfamoyl-3-benzylthiomethyl-2h-1,2,4-benzothiadiazine1,1-dioxide
  • Aquatag
  • Benzothiazide
  • Dihydrex
  • Diucen
  • diucene
  • Edemex
  • Exna
  • Exosalt
  • exva
  • fouane
  • Fovane
  • Freeuril
  • HyDrine
  • hy-drine
  • Lemazide
  • P 1393
  • p1393
  • Pfizer 1393
  • pfizer1393
  • Proaqua
  • regulon
  • Urese
  • Exsalt
  • 3-[(benzylthio)methyl]-6-chloro-1,1-diketo-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • CHEMBANK1114
  • BENZTHIAZIDE
  • BENZTHIAZIDE USP/EP/BP
  • 3-((Benzylthio)methyl)-6-chloro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
  • Inhibitor,Carbonate dehydratase,Carbonic Anhydrase,Benzthiazide,inhibit
  • Hydrochlorothiazide Impurity 31 (Benzthiazide)
  • Benzthiazide, 10 mM in DMSO
  • 91-33-8
  • C15H14ClN3O4S3
  • 43194
  • Heterocyclic Building Blocks