5-AMINO-3-BROMO (1H)INDAZOLE

Product Name: 5-AMINO-3-BROMO (1H)INDAZOLE
CAS No.: 478837-59-1
Chemical Name: 5-AMINO-3-BROMO (1H)INDAZOLE
Synonyms: 5-AMINO-3-BROMOINDAZOLE;3-bromo-1H-indazol-5-amine;3-bromo-2H-indazol-5-amine;1H-Indazol-5-aMine, 3-broMo-;5-AMINO-3-BROMO (1H)INDAZOLE;3-BroMo-1H-indazol-5-ylaMine
CBNumber: CB2193001
Molecular Formula: C7H6BrN3
Formula Weight: 212.05
MOL File: 478837-59-1.mol

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5-AMINO-3-BROMO (1H)INDAZOLE Property

Boiling point:: 431.3±25.0 °C(Predicted)
Density: 1.867±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.34±0.40(Predicted)
Appearance: Light brown to brown Solid

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Safety

RIDADR: UN2811
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B694410
Product name: 3-Bromo-1H-indazol-5-amine
Packaging: 500mg
Price: $180
Updated: 2021/12/16

TRC

Product number: B694410
Product name: 3-Bromo-1H-indazol-5-amine
Packaging: 2.5g
Price: $810
Updated: 2021/12/16

TRC

Product number: B694410
Product name: 3-Bromo-1H-indazol-5-amine
Packaging: 5g
Price: $1540
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142323
Product name: 3-Bromo-1H-indazol-5-amine
Packaging: 100mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142323
Product name: 3-Bromo-1H-indazol-5-amine
Packaging: 250mg
Price: $140
Updated: 2021/12/16

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5-AMINO-3-BROMO (1H)INDAZOLE Chemical Properties,Usage,Production

Uses

3-Bromo-1H-indazol-5-amine acts as a reagent for the preparation of Polycyclic indazole derivatives that are ERK inhibitors and their use in the treatment and prevention of cancer, anilino quinazolines as antitumor agents.

Synthesis

67400-25-3

478837-59-1

General procedure for the synthesis of 3-bromo-5-aminoindazole from 3-bromo-5-nitroindazole: Tin(II) chloride dihydrate (100.4 g, 44.62 mmol) was added batchwise to a solution of 3-bromo-5-nitro-1H-indazole (18.0 g, 7.43 mmol) in ethanol (400 mL) at 0°C. The reaction was carried out by stirring for 14 h at 80°C. The reaction was carried out in the same way that the reaction was carried out in the same way that the reaction was carried out in the same manner. The reaction mixture was then stirred at 80 °C for 14 hours. Upon completion of the reaction, the product was isolated and purified by standard methods, resulting in 3-bromo-1H-indazol-5-amine (14.5 g, 92%) as a light brown solid.

References

[1] Patent: WO2016/89977, 2016, A1. Location in patent: Paragraph 00193
[2] Patent: EP1403255, 2004, A1. Location in patent: Page 133
[3] Patent: WO2007/70398, 2007, A1. Location in patent: Page/Page column 193

5-AMINO-3-BROMO (1H)INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-3-BROMO (1H)INDAZOLE Suppliers

China 53 India 1 United Kingdom 4 United States 10 Global 68

Shanghai Ennopharm Co., Ltd.

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SuZhou ShiYa Biopharmaceuticals, Inc.

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ShangHai KenEn Chemical Technology Co., Ltd.

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478837-59-1, 5-AMINO-3-BROMO (1H)INDAZOLERelated Search:

3-Bromoindazole 5-AMINOINDAZOLE 4-AMINO-6-BROMO (1H)INDAZOLE 4-AMINO-3-BROMO (1H)INDAZOLE 3-AMINO-4-BROMO-1H-INDAZOLE 6-AMINO-3-BROMO (1H)INDAZOLE 5-AMINO-7-BROMO-1H-INDAZOLE 3-Bromo-1-methyl-5-nitro-1H-indazole 3-BROMO-5-NITRO-6-METHYL (1H)INDAZOLE 5-NITRO-3-BROMOINDAZOLE 5-AMINO-3-BROMO (1H)INDAZOLE 5-AMINO-3-BROMO-6-CHLORO (1H)INDAZOLE 5-AMINO-3-BROMO-6-METHYL (1H)INDAZOLE 5-Amino-3-bromo-1-methylindazole 3-BROMO-6-CHLORO-5-NITRO (1H)INDAZOLE

3-BroMo-1H-indazol-5-ylaMine

5-AMINO-3-BROMO (1H)INDAZOLE

5-AMINO-3-BROMOINDAZOLE

3-bromo-1H-indazol-5-amine

1H-Indazol-5-aMine, 3-broMo-

3-bromo-2H-indazol-5-amine

478837-59-1

C7H6BrN3

CHIRAL CHEMICALS