ChemicalBook > CAS DataBase List > METHYL 2,4-DIFLUOROBENZOATE

METHYL 2,4-DIFLUOROBENZOATE

Product Name: METHYL 2,4-DIFLUOROBENZOATE
CAS No.: 106614-28-2
Chemical Name: METHYL 2,4-DIFLUOROBENZOATE
Synonyms: RARECHEM AL BF 0213;METHYL 2,4-DIFLUOROBENZOATE;Methyl2,4-Difluorobenzoate>2,3-difluoro-4-methylbenzoate;Methyl 2,4-difluorobenzoate 97%;Methyl 2,4-difluorobenzoate ,97%;2,4-DIFLUORO-BENZOIC ACID METHYL ESTER;Benzoic acid, 2,4-difluoro-, methyl ester
CBNumber: CB2198394
Molecular Formula: C8H6F2O2
Formula Weight: 172.13
MOL File: 106614-28-2.mol

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METHYL 2,4-DIFLUOROBENZOATE Property

Boiling point:: 128-129 °C (lit.)
Density: 1.384 g/mL at 25 °C (lit.)
refractive index: n20/D 1.4840(lit.)
Flash point:: 180 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow to Light orange
InChI: InChI=1S/C8H6F2O2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3
InChIKey: YQUHULOBTDYMAG-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=C(F)C=C1F
CAS DataBase Reference: 106614-28-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595047
Product name: Methyl 2,4-difluorobenzoate
Purity: 97%
Packaging: 5g
Price: $62
Updated: 2025/07/31

TCI Chemical

Product number: M1879
Product name: Methyl 2,4-Difluorobenzoate
Purity: >98.0%(GC)
Packaging: 5g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: M1879
Product name: Methyl 2,4-Difluorobenzoate
Purity: >98.0%(GC)
Packaging: 25g
Price: $142
Updated: 2025/07/31

TRC

Product number: M301785
Product name: Methyl 2,4-Difluorobenzoate
Packaging: 25g
Price: $165
Updated: 2021/12/16

TRC

Product number: M301785
Product name: Methyl 2,4-Difluorobenzoate
Packaging: 10g
Price: $75
Updated: 2021/12/16

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METHYL 2,4-DIFLUOROBENZOATE Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

Methyl 2,?4-Difluorobenzoate is a reagent used in the synthesis of pharmaceuticals. Used in the design and synthesis of integrin αvβ3 antagonists displaying antiplatelet activity.

Synthesis

1583-58-0

106614-28-2

General procedure for the synthesis of methyl 2,4-difluorobenzoate from 2,4-difluorobenzoic acid: 1. 2,4-difluorobenzoic acid (1.5808 g, 10.00 mmol) was dissolved in methanol (15 mL) and cooled to 0 °C in an ice-water bath. 2. a methanol (10 mL) solution of thionyl chloride (1.46 mL, 20.02 mmol) was added slowly and dropwise to the above cooled mixture. 3. Gradually warm the reaction mixture to room temperature with continuous stirring for 24 hours. 4. Upon completion of the reaction, the mixture was poured into saturated aqueous NaHCO3 solution and extracted three times with ether. 5. The organic phases were combined and dried over anhydrous MgSO4. 6. The organic phase was concentrated under pressure and purified by silica gel column chromatography (eluent: hexane/ether=5/1) to give methyl 2,4-difluorobenzoate (1.6743 g, 97% yield). 7. The product was characterized by 1H-NMR (CDCl3): δ 7.99 (td, 1H, J=8.2,6.6 Hz), 6.98-6.84 (m, 2H), 3.93 (s, 3H).

References

[1] Patent: US6194461, 2001, B1

METHYL 2,4-DIFLUOROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

Fluconazole

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View Lastest Price from METHYL 2,4-DIFLUOROBENZOATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: METHYL 2,4-DIFLUOROBENZOATE 106614-28-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 2,4-DIFLUOROBENZOATE 106614-28-2
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-25

Career Henan Chemical Co

Product: METHYL 2,4-DIFLUOROBENZOATE 106614-28-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-08-07

106614-28-2, METHYL 2,4-DIFLUOROBENZOATERelated Search:

METHYL 2,4-DICHLOROBENZOATE METHYL PENTAFLUOROBENZOATE Ethyl 2,3,4,5-tetrafluorobenzoate ETHYL 2,4-DIFLUOROBENZOATE METHYL 2,4-DIFLUOROBENZOATE ETHYL PENTAFLUOROBENZOATE ETHYL 2,4,5-TRIFLUOROBENZOATE Tetrafluorophthalic anhydride METHYL 2,6-DIFLUOROBENZOATE,Methyl 2,6-difluorobenzoate 98%,Methyl2,6-difluorobenzoate98% Methyl 4-bromo-2,6-difluorobenzoate Methyl3,5-difluorobenzoate98%,Methyl 3,5-difluorobenzoate 98%,METHYL 3,5-DIFLUOROBENZOATE METHYL 3,4-DIFLUOROBENZOATE,Methyl 3,4-difluorobenzoate 97%,Methyl3,4-difluorobenzoate97% METHYL 2,3-DIFLUOROBENZOATE METHYL 2,5-DIFLUOROBENZOATE 2,4-Difluorobenzoic acid 2 3 4 5 6-PENTAFLUOROBENZOIC ANHYDRIDE ETHYL 2,4,5-TRIFLUORO-3-IODOBENZOATE AnthranceA

RARECHEM AL BF 0213

METHYL 2,4-DIFLUOROBENZOATE

2,4-DIFLUORO-BENZOIC ACID METHYL ESTER

Methyl 2,4-difluorobenzoate ,97%

Methyl 2,4-difluorobenzoate 97%

2,3-difluoro-4-methylbenzoate

Methyl2,4-Difluorobenzoate&gt

Benzoic acid, 2,4-difluoro-, methyl ester

106614-28-2

C8 to C9

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Esters

Aromatic Esters

Acids & Esters

Fluorine Compounds

C8 to C9

Carbonyl Compounds

Esters