METHYL 2,4-DIFLUOROBENZOATE
- Product Name
- METHYL 2,4-DIFLUOROBENZOATE
- CAS No.
- 106614-28-2
- Chemical Name
- METHYL 2,4-DIFLUOROBENZOATE
- Synonyms
- RARECHEM AL BF 0213;METHYL 2,4-DIFLUOROBENZOATE;Methyl2,4-Difluorobenzoate>2,3-difluoro-4-methylbenzoate;Methyl 2,4-difluorobenzoate 97%;Methyl 2,4-difluorobenzoate ,97%;2,4-DIFLUORO-BENZOIC ACID METHYL ESTER;Benzoic acid, 2,4-difluoro-, methyl ester
- CBNumber
- CB2198394
- Molecular Formula
- C8H6F2O2
- Formula Weight
- 172.13
- MOL File
- 106614-28-2.mol
METHYL 2,4-DIFLUOROBENZOATE Property
- Boiling point:
- 128-129 °C (lit.)
- Density
- 1.384 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.4840(lit.)
- Flash point:
- 180 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C8H6F2O2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3
- InChIKey
- YQUHULOBTDYMAG-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(F)C=C1F
- CAS DataBase Reference
- 106614-28-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 595047
- Product name
- Methyl 2,4-difluorobenzoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $62
- Updated
- 2025/07/31
- Product number
- M1879
- Product name
- Methyl 2,4-Difluorobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- M1879
- Product name
- Methyl 2,4-Difluorobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $142
- Updated
- 2025/07/31
- Product number
- M301785
- Product name
- Methyl 2,4-Difluorobenzoate
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- M301785
- Product name
- Methyl 2,4-Difluorobenzoate
- Packaging
- 25g
- Price
- $165
- Updated
- 2021/12/16
METHYL 2,4-DIFLUOROBENZOATE Chemical Properties,Usage,Production
Chemical Properties
Colorless to yellow liquid
Uses
Methyl 2,?4-Difluorobenzoate is a reagent used in the synthesis of pharmaceuticals. Used in the design and synthesis of integrin αvβ3 antagonists displaying antiplatelet activity.
Synthesis
1583-58-0
106614-28-2
General procedure for the synthesis of methyl 2,4-difluorobenzoate from 2,4-difluorobenzoic acid: 1. 2,4-difluorobenzoic acid (1.5808 g, 10.00 mmol) was dissolved in methanol (15 mL) and cooled to 0 °C in an ice-water bath. 2. a methanol (10 mL) solution of thionyl chloride (1.46 mL, 20.02 mmol) was added slowly and dropwise to the above cooled mixture. 3. Gradually warm the reaction mixture to room temperature with continuous stirring for 24 hours. 4. Upon completion of the reaction, the mixture was poured into saturated aqueous NaHCO3 solution and extracted three times with ether. 5. The organic phases were combined and dried over anhydrous MgSO4. 6. The organic phase was concentrated under pressure and purified by silica gel column chromatography (eluent: hexane/ether=5/1) to give methyl 2,4-difluorobenzoate (1.6743 g, 97% yield). 7. The product was characterized by 1H-NMR (CDCl3): δ 7.99 (td, 1H, J=8.2,6.6 Hz), 6.98-6.84 (m, 2H), 3.93 (s, 3H).
References
[1] Patent: US6194461, 2001, B1
METHYL 2,4-DIFLUOROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2,4-DIFLUOROBENZOATE Suppliers
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- 021-31261262/ 49 (0)17662837245
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- Germany
- ProdList
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View Lastest Price from METHYL 2,4-DIFLUOROBENZOATE manufacturers
- Product
- METHYL 2,4-DIFLUOROBENZOATE 106614-28-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- METHYL 2,4-DIFLUOROBENZOATE 106614-28-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-25
- Product
- METHYL 2,4-DIFLUOROBENZOATE 106614-28-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-08-07