1-Naphthylamine-4,6,8-trisulfonic acid
- Product Name
- 1-Naphthylamine-4,6,8-trisulfonic acid
- CAS No.
- 17894-99-4
- Chemical Name
- 1-Naphthylamine-4,6,8-trisulfonic acid
- Synonyms
- 1-NAPHTHYLAMINE-4,6,8-TRISULFONIC ACID;8-aminonaphthalene-1,3,5-trisulfonicaci;8-AMINO-1,3,5-NAPHTHALENETRISULFONIC ACID;8-azanylnaphthalene-1,3,5-trisulfonic acid;8-aminonaphthalene-1,3,5-trisulphonic acid;8-AMINO-NAPHTHALENE-1,3,5-TRISULFONIC ACID;1,3,5-Naphthalenetrisulfonic acid, 8-amino-
- CBNumber
- CB2201236
- Molecular Formula
- C10H9NO9S3
- Formula Weight
- 383.37
- MOL File
- 17894-99-4.mol
1-Naphthylamine-4,6,8-trisulfonic acid Property
- Density
- 1.974±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.75±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- CHM0006894
- Product name
- 1-NAPHTHYLAMINE-4,6,8-TRISULFONIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1127.86
- Updated
- 2021/12/16
- Product number
- 17894994
- Product name
- 8-Aminonaphthalene-1,3,5-trisulfonicacid
- Packaging
- 1g
- Price
- $1246
- Updated
- 2021/12/16
- Product number
- 17894994
- Product name
- 8-Aminonaphthalene-1,3,5-trisulfonicacid
- Packaging
- 5g
- Price
- $1917
- Updated
- 2021/12/16
- Product number
- CD12131218
- Product name
- 8-Aminonaphthalene-1,3,5-trisulfonicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $823
- Updated
- 2021/12/16
1-Naphthylamine-4,6,8-trisulfonic acid Chemical Properties,Usage,Production
Chemical Properties
1-Aminonaphthalene-4,6,8-trisulfonic acid [17894-99-4]. (8-aminonaphthalene1,3,5-trisulfonic acid), B acid, C10H9NO9S3, Mr 383.36, is reduced with zinc and alkali to 1- aminonaphthalene-4,6-disulfonic acid. Heating with aqueous sulfuric acid causes desulfonation to form 1-aminonaphthalene-6,8-disulfonic acid. Sulfonation (25 % oleum, 90℃) gives the sultam of 1-aminonaphthalene-2,4,6,8-tetrasulfonic acid.
Uses
Alkali fusion of B acid yields K acid. A special outlet for purified B acid is in the synthesis of the drug suramin sodium (Bayer 205) . 1-Aminonaphthalene-4,6,8-trisulfonic acid is acylated with 2-nitrotoluyl chloride, and this product is reduced and acylated with mnitrobenzoyl chloride. This intermediate is reduced and finally phosgenated to give suramin sodium, which has been used to treat trypanosomiasis and onchocerciasis.
Production Methods
Naphthalene is sulfonated under conditions that maximize formation of the 1,3,5-trisulfonic acid, followed by nitration with H2SO4– HNO3 in situ at 35℃. After quenching, neutralization with calcium carbonate, and reduction of the nitro-derivative with iron under acid conditions, the byproduct 1- aminonaphthalene-3,6,8-trisulfonic acid (18 % yield) is selectively precipitated by acidification. The desired isomer is then precipitated by further acidification and salting of the filtrates, and finally purified by reprecipitation. Overall yield is 25 – 30 %.
1-Naphthylamine-4,6,8-trisulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-Naphthylamine-4,6,8-trisulfonic acid Suppliers
- Tel
- --
- Fax
- --
- enquiry@leancare.co.uk
- Country
- United Kingdom
- ProdList
- 6446
- Advantage
- 42
- Tel
- --
- Fax
- --
- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
View Lastest Price from 1-Naphthylamine-4,6,8-trisulfonic acid manufacturers
- Product
- 1-Naphthylamine-4,6,8-trisulfonic acid 17894-99-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-19