2,2'-Anhydro-5-methyluridine

Product Name: 2,2'-Anhydro-5-methyluridine
CAS No.: 22423-26-3
Chemical Name: 2,2'-Anhydro-5-methyluridine
Synonyms: TK-112690;2,2`-CyclothyMidine;2,2'-Anhydro-5-Me-U;2,2'-Anhydro-5-methy;2,2'-Anhydrothimidine;5-Me-2, 2'-Anhydro-rU;2,2'-Anhydrothymidine;2,2'-Anhydrothymidine;L-2,2'-AnhydrothyMidine;2,2'-Anhydro-D-thymidine
CBNumber: CB2205315
Molecular Formula: C10H12N2O5
Formula Weight: 240.21
MOL File: 22423-26-3.mol

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2,2'-Anhydro-5-methyluridine Property

Melting point:: 217.0 to 221.0 °C
Boiling point:: 452.0±55.0 °C(Predicted)
Density: 1.88±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Water Solubility: Soluble in water
form: powder to crystal
pka: 12.56±0.60(Predicted)
color: White to Almost white
InChI: InChI=1S/C10H12N2O5/c1-4-2-12-9-7(6(14)5(3-13)16-9)17-10(12)11-8(4)15/h2,5-7,9,13-14H,3H2,1H3/t5-,6-,7+,9-/m1/s1
InChIKey: WLLOAUCNUMYOQI-JAGXHNFQSA-N
SMILES: C12O[C@@]3([H])[C@H](O)[C@@H](CO)O[C@@]3([H])N1C=C(C)C(=O)N=2
CAS DataBase Reference: 22423-26-3(CAS DataBase Reference)

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Safety

HS Code: 2940.00.6000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2431
Product name: 2,2'-O-Anhydro-5-methyluridine
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $90
Updated: 2025/07/31

TRC

Product number: A638163
Product name: 2,2''-O-Anhydro-5-methyluridine
Packaging: 5g
Price: $45
Updated: 2021/12/16

TRC

Product number: A638163
Product name: 2,2''-O-Anhydro-5-methyluridine
Packaging: 50g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: J53379
Product name: 2,2'-Anhydrothymidine
Packaging: 100g
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NA06711
Product name: 2,2'-Anhydrothymidine
Packaging: 100g
Price: $150
Updated: 2021/12/16

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2,2'-Anhydro-5-methyluridine Chemical Properties,Usage,Production

Chemical Properties

Colourless solid

Synthesis

1463-10-1

22423-26-3

The following is the general procedure for the synthesis of (2R,3R,3aS,9aR)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one from 5-methyluridine: 1. reaction catalyzed by diphenyl carbonate and NaHCO3 in DMF at 100 °C in 90% yield. 2. reaction using DMTCl in pyridine at room temperature in 89% yield. 3. reaction catalyzed by ethylene glycol, Ti(OiPr)4 and NaHCO3 in THF at 150 °C in 79% yield. 4. reaction with MsCl and Et3N in DCM in 57% yield. 5. reaction using NaN3 and 18-crown-6 in DMF in 89% yield. 6. reaction in THF with Ph3P and H2O in 89% yield. 7. reaction in DCM and Et3N in 88% yield. 8. finally, reaction with (iPr)2NP(Cl)OCH2CH2CN and DIPEA in DCM at room temperature in 59.4% yield.

References

[1] Patent: CN103450302, 2016, B. Location in patent: Paragraph 0096-0098; 0110
[2] Patent: US2013/231473, 2013, A1. Location in patent: Paragraph 0158
[3] Patent: US2005/107324, 2005, A1. Location in patent: Page/Page column 26
[4] Journal of the Brazilian Chemical Society, 2015, vol. 26, # 4, p. 816 - 821
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 5, p. 1641 - 1652

2,2'-Anhydro-5-methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2'-Anhydro-5-methyluridine Suppliers

Americas 1 China 189 Europe 2 Germany 2 India 6 Japan 1 Russia 1 Slovakia 1 Switzerland 1 United Kingdom 3 United States 14 Global 221

Xiangyang Meijun Machinery Technology Testing Co., Ltd.

Tel: 13774177198
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Hangzhou Measure Life Technology Co.,LTD

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Jiangsu Xinderui Pharmaceutical Technology Co., Ltd

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Hongene Biotech Corporation

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TCI (Shanghai) Development Co., Ltd.

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Wuhu Huaren Science and Technology Co., Ltd.

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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
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Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
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View Lastest Price from 2,2'-Anhydro-5-methyluridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,2'-Anhydro-5-methyluridine 22423-26-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-06-25

Henan Aochuang Chemical Co.,Ltd.

Product: 2,2'-Anhydro-5-methyluridine 22423-26-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

Shaanxi Dideu Medichem Co. Ltd

Product: 2,2'-Anhydro-5-methyluridine 22423-26-3
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-25

22423-26-3, 2,2'-Anhydro-5-methyluridineRelated Search:

Tiglic aldehyde CHLOROPHOSPHONAZO III 2,4-Dimethyl aniline Doxifluridine 5-Methyluridine 2,6-Lutidine Trifluridine L-Uridine Uridine uridine diphosphate glucose {= UDP-glucose} 4-Hydroxypyrimidine 2,2'-Cyclouridine 4(1H)-Pyrimidinone, 2-methoxy- (9CI) 2,2'-Anhydro-5-methyluridine

2,2'-cyclo-5-methyluridine

2,2'-Anhydrothimidine

Uridine,2,2'-cyclo-5-methyl

2,2'-Anhydro-D-thymidine

2,2’-Cryclo-5-methyluridine

2,2''-Anhydro-(1-beta-D-arabinofuranosyl)-5-methyluracil

6H-Furo[2'',3'':4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-7-methyl-, (2R,3R,3aS, 9aR)-

(2R)-2,3,3aβ,9aβ-Tetrahydro-3β-hydroxy-2α-(hydroxymethyl)-7-methyl-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one

(8R,10R,11R,12S)-5-Methyl-10-(hydroxymethyl)-11-hydroxy-2,7:8,12-dicyclo-1,9-dioxa-3,7-diazacyclododeca-2,5-diene-4-one

2,2'β-Oxy-2-deoxo-2,3-didehydro-2'-deoxy-5-methyluridine

2'β,2-Epoxy-2,3-didehydro-2-deoxothymidine

5-Methyl-2,2'β-epoxy-2'-deoxy-2-deoxo-2,3-didehydrouridine

2,2'-anhydro-1-beta-arabinofuranosylthymine

2,2'-ANHYDRO-(1-BETA-D-ARABINOFURANOSYL)THYMINE

2,2'-Anhydro-11-beta-D-arabinofuranosylthymine

2,2'-ANHYDRO-(1-E-D-ARABINOFURANOSYL)-5-METHYLURACIL

(2r-(2alpha,3beta,3abeta,9abeta))-2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-7-methyl-6h-furo(2',3':4,5)oxazolo(3,2-a)pyrimidin-6-one

6H-FURO[2',3':4,5]OXAZOLO[3,2-A]PYRIMIDIN-6-ONE,2,3,3A,9A-TETRAHYDRO-3-HYDROXY-2-(HYDROXYMETHYL)-7-METHYL-, (2R,3R,3AS, 9AR)-

-Anhydro-5-methyluridine

O2,2'-Anhydro-5-methyluridine

L-2,2'-AnhydrothyMidine

2,2`-CyclothyMidine

2,2'-Anhydro-5-Me-U

2,2'-O-Anhydro-(1-beta-D-arabinofuranosyl)-5-methyluracil

(2R,3R,3aS,9aR)-3-Hydroxy-2-(hydroxymethyl)-7-methyl-3,3a-dihydro-2H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6(9aH)-one

2,2'-O-Anhydro-5-methyluridine, 98.0%

(2R,4R,5R,6S)-5-HYDROXY-4-(HYDROXYMETHYL)-11-METHYL-3,7-DIOXA-1,9-DIAZATRICYCLO[6.4.0.0,DODECA

2'2-anhydro-5methyluridine (synthetic production)

5-methyl-2, 2'-Anhydro-Ur

2,2'-O-Anhydro-5-methyluridine &gt

2,2'-Anhydro-5-methy

(2R,3R,3aS,9aR)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-6-one

(2R,3R,3aS,9aR)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one

2,2-ANHYDRO-1-Β-D- ARABINOFURANOSYLTHYMINE

2,2'-Anhydro-5-methyluridine/O2,2'-Anhydro-5-methyluridine

O-2,2'-cyclo-5-methyluridine

5-Me-2, 2'-Anhydro-rU

2,2 '- Dehydrated 5-methyluridine

2,2'-Anhydro-5-methyluridine

2,2'-O-Anhydro-5-methyluridine

2,2'-Anhydrothymidine

O-2,2’-Anhydro-5-methyluridine

(2R,4R,5R,6S)-5-hydroxy-4-(hydroxymethyl)-11-methyl-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,?]dodeca-8,11-dien-10-one

5-methyl-2, 2'-Anhydro-Uridine

2,2'-Anhydrothymidine

TK-112690

22423-26-3