Description References
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Cinobufagin

Description References
Product Name
Cinobufagin
CAS No.
470-37-1
Chemical Name
Cinobufagin
Synonyms
FEMA 2288;AKOS 233-01;CINOBUFAGIN;16-beta)-bet;cinobufagine;AKOS B004228;CINOBUFAGIN(P);Cinobufagin-RM;Cinobufagin std.;Cinobufagin (6CI)
CBNumber
CB2206701
Molecular Formula
C26H34O6
Formula Weight
442.55
MOL File
470-37-1.mol
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Cinobufagin Property

Melting point:
133 °C(lit.)
Boiling point:
300 °C(lit.)
Density 
1.261 g/cm3
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
pka
15.10±0.70(Predicted)
form 
powder to crystal
color 
White to Light yellow
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Safety

Hazard Codes 
Xi,T+,Xn
Risk Statements 
36/37/38-26/27/28-42/43-20/22
Safety Statements 
26-36-45-36/37/39-22-24/25
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
RTECS 
GD7850000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3460
Product name
Cinobufagine
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$304
Updated
2024/03/01
TCI Chemical
Product number
C3460
Product name
Cinobufagine
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$908
Updated
2024/03/01
Cayman Chemical
Product number
19844
Product name
Cinobufagin
Packaging
5mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
19844
Product name
Cinobufagin
Packaging
50mg
Price
$566
Updated
2024/03/01
Cayman Chemical
Product number
19844
Product name
Cinobufagin
Packaging
10mg
Price
$206
Updated
2024/03/01
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Cinobufagin Chemical Properties,Usage,Production

Description

Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.

References

1. https://en.wikipedia.org/wiki/Cinobufagin
2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412
3. http://www.yourdictionary.com/cinobufagin
4. https://www.medchemexpress.com/cinobufagin.html

Description

Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.

Uses

Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.

Definition

ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.

Cinobufagin Preparation Products And Raw materials

Raw materials

Preparation Products

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Cinobufagin Suppliers

Americas 1 Canada 1 China 178 Europe 2 Germany 2 India 2 Japan 2 Switzerland 2 United Kingdom 8 United States 26 Global 224
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
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View Lastest Price from Cinobufagin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Cinobufagin 470-37-1
Price
US $1.00-100.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
300KG
Release date
2024-07-26
Shanghai Standard Technology Co., Ltd.
Product
Cinobufagin 470-37-1
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-10-10
Shanghai Standard Technology Co., Ltd.
Product
Cinobufagin 470-37-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-10

470-37-1, CinobufaginRelated Search:

Cellulose acetate Ammonium acetate Glatiramer acetate Vinyl acetate POLY(VINYL ACETATE) Sodium acetate Ethyl acetate CIS-2,3-EPOXYBUTANE (S)-1,2-EPOXYOCTANE 1,2-EPOXY-5-HEXENE Resibufogenin 7-OCTEN-2-OL, 2-METHYL-6-METHYLENE TRANS-2,3-EPOXYBUTANE 1,2-EPOXY-9-DECENE Isopentyl ether FEMA 2348 (S)-(+)-Methyl glycidyl ether ACETATE

  • RARECHEM BK HC T302
  • 5b,20(22)-Bufadienolide-3b,16b-diol-14,15b-epoxy 16-acetate
  • CINOBUFAGIN95%,99%
  • CINOBUFAGIN(P)
  • TRANS-3-PHENYLPROPENOIC ACID
  • TRANS-3-BENZENEPROPENOIC ACID
  • TRANS-CINNAMYLIC ACID
  • Cinobufagin std.
  • 16β-Acetoxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
  • 16β-Acetyloxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
  • 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
  • 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate
  • 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate, 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
  • Cinobufogenin，Cinobufagin
  • 5-((1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-2-Acetyl-7-hydroxy-9a,11a-diMethylhexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-1-yl)-2H-pyran-2-one
  • Cinobufagin, 98%, from cinobufagin venom toad
  • 16-beta)-bet
  • 22-dienolide,16-(acetyloxy)-14,15-epoxy-3-hydroxy-,(3-beta,5-beta,15-bufa-2
  • cinobufagine
  • AKOS B004228
  • AKOS 233-01
  • 3-STYRYLACRYLIC ACID
  • 3-PHENYLACRYLIC ACID
  • 5BETA,20[22]-BUFADIENOLIDE-3BETA,16BETA-DIOL-14,15BETA-EPOXY 16-ACETATE
  • 2-PROPENOIC ACID, 3-PHENYL-, (2E)-
  • 14,15BETA-EPOXY-3BETA,16BETA-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE 16-ACETATE
  • BETA-PHENYLACRYLIC ACID
  • FEMA 2288
  • CINNAMIC ACID, TRANS-
  • CINOBUFAGIN
  • cinobufagin venom toad
  • Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)-
  • Cinobufagin (Cinobufagine)
  • Cinobufagin (6CI)
  • (1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate
  • Chinese bufotoxin
  • (1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate
  • Cinobufagin-RM
  • 470-37-1
  • C26H34O6
  • C26H34O6nH2O
  • Proteomics and Protein Expression
  • Protein Analysis
  • Organic Building Blocks
  • Matrices for MALDI Analysis
  • Auxins
  • Mass Spectrometry
  • Matrix Materials (MALDI-TOF-MS)
  • Plant Growth Regulators
  • BioChemical
  • Building Blocks
  • C9
  • Carbonyl Compounds
  • Carboxylic Acids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).