Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
Uses- Product Name
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
- CAS No.
- 178306-52-0
- Chemical Name
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
- Synonyms
- ALST-3;S-2-Hydroxy-3-methoxy-3;3-diphenylpropanoic acid;AMbrisentan InterMediate;Ambrisentan Hydroxy Impurity;Ambrisentan Related compound A;Ambrisentan Hydroxy Acid Impurity;Ambrisentan Hydroxy Acid Impurity (S-Isomer);(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid;(S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
- CBNumber
- CB22077327
- Molecular Formula
- C16H16O4
- Formula Weight
- 272.3
- MOL File
- 178306-52-0.mol
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Property
- Melting point:
- 121 °C
- Boiling point:
- 430.3±45.0 °C(Predicted)
- Density
- 1.248
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly)
- pka
- 3.24±0.28(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)/t14-/s3
- InChIKey
- RQJWOLFMWKZKCJ-WDHUHKLTNA-N
- SMILES
- C(OC)(C1=CC=CC=C1)(C1C=CC=CC=1)[C@H](O)C(=O)O |&1:15,r|
Safety
- HS Code
- 2918.99.4700
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- H1568
- Product name
- (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $166
- Updated
- 2025/07/31
- Product number
- H1568
- Product name
- (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $499
- Updated
- 2025/07/31
- Product number
- H946110
- Product name
- (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
- Packaging
- 250mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- J11359
- Product name
- AmbrisentanHydroxyAcidImpurity
- Packaging
- 100mg
- Price
- $106
- Updated
- 2021/12/16
- Product number
- 39523
- Product name
- (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionicacid,98%(Assaybytitration,GC)
- Purity
- 98%(Assaybytitration,GC)
- Packaging
- 1G
- Price
- $359.52
- Updated
- 2021/12/16
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Chemical Properties,Usage,Production
Uses
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity.
Chemical Properties
White powder
Uses
(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity
Synthesis
178306-51-9
178306-52-0
The general procedure for the synthesis of (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid from 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was as follows: 500 mg (1.84 mmol) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was dissolved in 8 mL of 2-propanol, followed by addition of 135 mg (0.92 mmol) of (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine. The reaction mixture was stirred under heated reflux conditions for 1 hour, then cooled to room temperature and continued stirring for 2 hours. The precipitated crystals were collected by filtration, washed with 2-propanol and finally dried under reduced pressure. The same operations as in Example 1 were performed according to the solvents listed in Table 1.
References
[1] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0041; 0042; 0045; 0046
[2] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 11-12
[3] Patent: CN104098462, 2017, B. Location in patent: Paragraph 0009; 0028; 0029; 0031
[4] Patent: JP5700378, 2015, B2. Location in patent: Paragraph 0071; 0072
[5] Patent: WO2013/57468, 2013, A1. Location in patent: Page/Page column 23-24
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- manufacturers
- Product
- (S)- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid 178306-52-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 100kg
- Release date
- 2021-11-20
- Product
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- 178306-52-9
- Price
- US $6.00/KG
- Min. Order
- 1g
- Purity
- 98%HPLC
- Supply Ability
- 20tons
- Release date
- 2020-10-28
- Product
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- 178306-52-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10