ChemicalBook > CAS DataBase List > Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-

Uses

Product Name: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
CAS No.: 178306-52-0
Chemical Name: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
Synonyms: ALST-3;S-2-Hydroxy-3-methoxy-3;3-diphenylpropanoic acid;AMbrisentan InterMediate;Ambrisentan Hydroxy Impurity;Ambrisentan Related compound A;Ambrisentan Hydroxy Acid Impurity;Ambrisentan Hydroxy Acid Impurity (S-Isomer);(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid;(S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
CBNumber: CB22077327
Molecular Formula: C16H16O4
Formula Weight: 272.3
MOL File: 178306-52-0.mol

Less

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Property

Melting point:: 121 °C
Boiling point:: 430.3±45.0 °C(Predicted)
Density: 1.248
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly)
pka: 3.24±0.28(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)/t14-/s3
InChIKey: RQJWOLFMWKZKCJ-WDHUHKLTNA-N
SMILES: C(OC)(C1=CC=CC=C1)(C1C=CC=CC=1)[C@H](O)C(=O)O |&1:15,r|

Less

Safety

HS Code: 2918.99.4700

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: H1568
Product name: (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $166
Updated: 2025/07/31

TCI Chemical

Product number: H1568
Product name: (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $499
Updated: 2025/07/31

TRC

Product number: H946110
Product name: (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid
Packaging: 250mg
Price: $600
Updated: 2021/12/16

Chem-Impex

Product number: 39523
Product name: (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionicacid,98%(Assaybytitration,GC)
Purity: 98%(Assaybytitration,GC)
Packaging: 5G
Price: $1214.08
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0000357
Product name: (S)-2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPIONIC ACID
Purity: 95.00%
Packaging: 1KG
Price: $20212.5
Updated: 2021/12/16

Less

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Chemical Properties,Usage,Production

Uses

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity.

Chemical Properties

White powder

Uses

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity

Synthesis

178306-51-9

178306-52-0

The general procedure for the synthesis of (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid from 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was as follows: 500 mg (1.84 mmol) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid was dissolved in 8 mL of 2-propanol, followed by addition of 135 mg (0.92 mmol) of (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine. The reaction mixture was stirred under heated reflux conditions for 1 hour, then cooled to room temperature and continued stirring for 2 hours. The precipitated crystals were collected by filtration, washed with 2-propanol and finally dried under reduced pressure. The same operations as in Example 1 were performed according to the solvents listed in Table 1.

References

[1] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0041; 0042; 0045; 0046
[2] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 11-12
[3] Patent: CN104098462, 2017, B. Location in patent: Paragraph 0009; 0028; 0029; 0031
[4] Patent: JP5700378, 2015, B2. Location in patent: Paragraph 0071; 0072
[5] Patent: WO2013/57468, 2013, A1. Location in patent: Page/Page column 23-24

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Suppliers

Americas 1 China 155 Europe 1 Germany 1 India 16 Japan 1 United States 9 Global 184

Jinan Cheminn Chemicals Co., Ltd.

Tel: 531-67875205 15726170169
Fax: +86-531-67875205
Email: sales@cheminn.com
Country: China
ProdList: 60
Advantage: 60

Shandong Kongfu Pharmaceutical Co

Tel: 0537-4442222 18854777456
Email: 871825068@qq.com
Country: China
ProdList: 15
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 239
Advantage: 61

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 998
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Shanghai Union Resource Chemistry Co., Ltd

Tel: 021-50454025 18930054025
Fax: 021-50454025
Country: China
ProdList: 103
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3853
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4942
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Chengdu Aslee Biopharmaceuticals, Inc

Tel: 028-85305008 02885305008
Fax: 4000210878-186
Email: 2306208234@qq.com
Country: China
ProdList: 1006
Advantage: 50

Suzhou Huihe Pharmaceutical Co. Ltd.

Tel: 86-0512-88819360,88985990
Fax: 86-0512-86876095
Email: asynderm@163.com
Country: China
ProdList: 90
Advantage: 60

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Hotechem Shanghai Co., Ltd.,

Tel: 021-34621078 13120882795
Fax: 021-34622517
Email: 465106944@qq.com
Country: China
ProdList: 857
Advantage: 56

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

Shanghai Mayzem Pharmtech Co., Ltd.

Tel: 18501708306; 18501708306
Fax: 021-68362870
Email: sales@mayzem.com
Country: China
ProdList: 518
Advantage: 56

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: sales@chemwill.com
Country: China
ProdList: 1974
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

Hubei widely chemical technology Co., Ltd.

Tel: 027-83991130 18627774460
Fax: 027-83991130
Email: 1718093273@QQ.COM
Country: China
ProdList: 1676
Advantage: 58

Beijing Bewellunion Pharmaceutical Co., Ltd.

Tel: 18601958187
Fax: 18601958187
Email: 247340078@qq.com
Country: China
ProdList: 144
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Qiandu Biological Technology Co., Ltd.

Tel: 021-61535850
Email: 2911799694@qq.com
Country: China
ProdList: 208
Advantage: 58

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2944
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Wuhan Netcom Electronic Commerce Limited

Tel: 18064670521
Fax: 0757-88210752
Email: 2355935187@ycphar.com
Country: China
ProdList: 4879
Advantage: 58

Jiangsu United-value International Trading Co., Ltd.

Tel: 0519-89885611 89885616 15312500313
Fax: +86(519)89885615
Email: luke.li@uvcs.cn.com
Country: China
ProdList: 469
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 2005
Advantage: 64

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Xiaoxian Tianxingjian Chemical Technology Co., Ltd.

Tel: 18949166171
Email: sales@txjchemical.com
Country: China
ProdList: 45
Advantage: 58

Alchemist-pharm chemical Technology Co. Ltd.

Tel: 0371-67991738 13783628208
Fax: QQ 412703949
Email: carl@alchemist-pharm.com
Country: China
ProdList: 1872
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Suzhou Sonic Biotech Co. Ltd.

Tel: 18106139113
Country: China
ProdList: 201
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Less

View Lastest Price from Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (S)- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid 178306-52-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 100kg
Release date: 2021-11-20

Career Henan Chemica Co

Product: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- 178306-52-9
Price: US $6.00/KG
Min. Order: 1g
Purity: 98%HPLC
Supply Ability: 20tons
Release date: 2020-10-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- 178306-52-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

178306-52-0, Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-Related Search:

(S)-4-HydroxyMethyl AMbrisentan (R)-AMbrisentan (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester rac-Ambrisentan-d5 MATFPFPXUXCLHI-UHFFFAOYSA-N FELOPRENTAN Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- 2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid 4,6-Dimethyl-2-hydroxypyrimidine Ambrisentan Ambrisentan pyrimidine Ester Impurity Ambrisentan Hydroxy Acid Impurity (R-isomer) Ambrisentan N-Oxide Ambrisentan Acyl Glucuronide (Mixture of Diastereomers) DARUSENTAN 4-Hydroxy Methyl Ambrisentan-D3 4-Hydroxymethyl ambrisentan acyl beta-glucuronide

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-

(S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid

(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid

(S)-2-Hydroxyl -3-Methoxy-3,3-diphenylpropanoic acid

AMbrisentan InterMediate

Ambrisentan Hydroxy Acid Impurity

(<i>S</i>)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid

3-diphenylpropanoic acid

S-2-Hydroxy-3-methoxy-3

ALST-3

(2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid

Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-, (αS)-

"(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid"Q: What is "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What is the CAS Number of "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What is the storage condition of "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What are the applications of "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid"

Ambrisentan Hydroxy Acid Impurity (S-Isomer)

Ambrisentan Hydroxy Impurity

Ambrisentan Related compound A

178306-52-0

178306-52-9

Drug Intermediates