Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

Product Name: Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
CAS No.: 73029-73-9
Chemical Name: Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
Synonyms: CyPPA;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl);KcsA,inhibit,CyPPA,Potassium Channel,Inhibitor;N-Cyclohexyl-N-[2-(3,5-diMethyl-pyrazol-1-yl)-6-Methyl-4-pyriMid;N-cyclohexyl-6-methyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine;N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine;Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine;N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine;4-PyriMidinaMine, N-cyclohexyl-2-(3,5-diMethyl-1H-pyrazol-1-yl)-6-Methyl-
CBNumber: CB22094094
Molecular Formula: C16H23N5
Formula Weight: 285.39
MOL File: 73029-73-9.mol

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Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Property

Boiling point:: 512.2±42.0 °C(Predicted)
Density: 1.23
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: solid
pka: 4.19±0.10(Predicted)
color: white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5493
Product name: CyPPA
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: C5493
Product name: CyPPA
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $660
Updated: 2024/03/01

Cayman Chemical

Product number: 15614
Product name: CyPPA
Purity: ≥98%
Packaging: 10mg
Price: $127
Updated: 2024/03/01

Cayman Chemical

Product number: 15614
Product name: CyPPA
Purity: ≥98%
Packaging: 50mg
Price: $601
Updated: 2024/03/01

Tocris

Product number: 2953
Product name: CyPPA
Purity: ≥99%(HPLC)
Packaging: 5
Price: $103
Updated: 2021/12/16

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Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Chemical Properties,Usage,Production

Uses

CyPPA is a positive SK3/SK2 modulator that reduces the activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methyl phenidate.

Uses

CyPPA has been used:

to test its inhibitory functionality on melanogenesis
as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells

Biological Activity

Activator of small conductance Ca 2+ -activated K + channels that displays selectivity for SK2 and SK3 channels (EC 50 values are 5.6 and 14 μ M for SK3 and SK2 respectively). Displays no activity at SK1 and IK channels.

Biochem/physiol Actions

CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.

storage

+4°C

Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Suppliers

China 56 India 1 Switzerland 1 United Kingdom 3 United States 12 USA 1 Global 74

3B Pharmachem (Wuhan) International Co.,Ltd.

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Sigma-Aldrich

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EMMX Biotechnology LLC

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MQ (shanghai) Pharmaceuticals Co., Ltd.

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Aikon International Limited

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73029-73-9, Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amineRelated Search:

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Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

CyPPA

N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

N-Cyclohexyl-N-[2-(3,5-diMethyl-pyrazol-1-yl)-6-Methyl-4-pyriMid

4-PyriMidinaMine, N-cyclohexyl-2-(3,5-diMethyl-1H-pyrazol-1-yl)-6-Methyl-

N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine

N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine

N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)

N-cyclohexyl-6-methyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine

KcsA,inhibit,CyPPA,Potassium Channel,Inhibitor

73029-73-9