ChemicalBook > CAS DataBase List > Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
- Product Name
- Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
- CAS No.
- 73029-73-9
- Chemical Name
- Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
- Synonyms
- CyPPA;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl);KcsA,inhibit,CyPPA,Potassium Channel,Inhibitor;N-Cyclohexyl-N-[2-(3,5-diMethyl-pyrazol-1-yl)-6-Methyl-4-pyriMid;N-cyclohexyl-6-methyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine;N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine;N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine;Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine;N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine;4-PyriMidinaMine, N-cyclohexyl-2-(3,5-diMethyl-1H-pyrazol-1-yl)-6-Methyl-
- CBNumber
- CB22094094
- Molecular Formula
- C16H23N5
- Formula Weight
- 285.39
- MOL File
- 73029-73-9.mol
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Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Property
- Boiling point:
- 512.2±42.0 °C(Predicted)
- Density
- 1.23
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- pka
- 4.19±0.10(Predicted)
- color
- white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C5493
- Product name
- CyPPA
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $149
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- C5493
- Product name
- CyPPA
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $660
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15614
- Product name
- CyPPA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $127
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15614
- Product name
- CyPPA
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $601
- Updated
- 2024/03/01
Tocris
- Product number
- 2953
- Product name
- CyPPA
- Purity
- ≥99%(HPLC)
- Packaging
- 25
- Price
- $389
- Updated
- 2021/12/16
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Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Chemical Properties,Usage,Production
Uses
CyPPA is a positive SK3/SK2 modulator that reduces the activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methyl phenidate.
Uses
CyPPA has been used:
- to test its inhibitory functionality on melanogenesis
- as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
- in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells
Biological Activity
Activator of small conductance Ca 2+ -activated K + channels that displays selectivity for SK2 and SK3 channels (EC 50 values are 5.6 and 14 μ M for SK3 and SK2 respectively). Displays no activity at SK1 and IK channels.
Biochem/physiol Actions
CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.
storage
+4°C
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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