OLSALAZINE

Product Name: OLSALAZINE
CAS No.: 15722-48-2
Chemical Name: OLSALAZINE
Synonyms: azodisal;Ph-CJ-91B;Dipentium;OLSALAZINE;Olsalazine D6;Olsalazine-13C6;Olsalazine 13C12;c.i.mordantyellow5;OLSALAZINE USP/EP/BP;OLSALAZINE 15722-48-2
CBNumber: CB2211118
Molecular Formula: C14H10N2O6
Formula Weight: 302.24
MOL File: 15722-48-2.mol

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OLSALAZINE Property

Melting point:: >300 °C(Solv: acetic acid (64-19-7); water (7732-18-5))
Boiling point:: 443.29°C (rough estimate)
Density: 1.3578 (rough estimate)
refractive index: 1.6500 (estimate)
solubility: DMSO: soluble
Methanol: soluble
form: Solid
pka: 2.40±0.10(Predicted)
color: Light yellow to yellow
Water Solubility: 11.49ug/L(25 ºC)
CAS DataBase Reference: 15722-48-2(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0003678
Product name: OLSALAZINE
Purity: 95.00%
Packaging: 25MG
Price: $191.1
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: ND34110
Product name: Olsalazine-d3,15Nsodium
Packaging: 5mg
Price: $1900
Updated: 2021/12/16

AvaChem

Product number: 1653A
Product name: Olsalazine
Packaging: 50mg
Price: $79
Updated: 2021/12/16

AvaChem

Product number: 1653A
Product name: Olsalazine
Packaging: 250mg
Price: $195
Updated: 2021/12/16

AvaChem

Product number: 1653A
Product name: Olsalazine
Packaging: 1g
Price: $349
Updated: 2021/12/16

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OLSALAZINE Chemical Properties,Usage,Production

Uses

Anti-inflammatory (gastrointestinal).

Definition

ChEBI: An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease.

Indications

Olsalazine is approved for maintenance of remission of ulcerative colitis, but a commonly reported side effect is a paradoxical increase in diarrhea. The U. S. Food and Drug Administration (FDA) has approved balsalazide disodium (Colazal) as a treatment of mild to moderately active ulcerative colitis.

brand name

Dipentum (UCB).

Mechanism of action

Olsalazine is approved for maintenance of remission of ulcerative colitis, but a commonly reported side effect is a paradoxical increase in diarrhea. The U. S. Food and Drug Administration (FDA) has approved balsalazide disodium (Colazal) as a treatment of mild to moderately active ulcerative colitis.

Veterinary Drugs and Treatments

Olsalazine is used for treatment of dogs with chronic colitis that either cannot tolerate the adverse effects associated with sulfasalazine or the response to sulfasalazine has been ineffective.

References

[1] S. NUGENT. Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs[J]. Gut, 2001, 48 1: 571-577. DOI: 10.1136/gut.48.4.571
[2] R. PAMUKCU E C S Hanauer. Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicylic acid.[J]. Gastroenterology, 1988, 95 4 1: 975-981. DOI: 10.5555/uri:pii:0016508588901722
[3] A Q MOHSEN. Effects of olsalazine in the jejunum of the rat.[J]. Gut, 1987, 28 3: 346-352. DOI: 10.1136/gut.28.3.346
[4] S MURTHY. The efficacy of BAY y 1015 in dextran sulfate model of mouse colitis.[J]. Inflammation Research, 1997, 46 6: 224-233. DOI: 10.1007/s000110050177
[5] YANFEN NIU . Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity[J]. Journal of pharmacological sciences, 2017, 135 3: Pages 114-120. DOI: 10.1016/j.jphs.2017.10.007

OLSALAZINE Preparation Products And Raw materials

Raw materials

Salicylic acid Methanesulfonyl chloride METHYL 5-NITROSALICYLATE

Preparation Products

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OLSALAZINE Suppliers

China 62 Europe 3 Germany 1 India 3 South Korea 1 United Kingdom 3 United States 11 Global 84

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
Advantage: 60

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3936
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hubei XinMingTai Chemical Co., Ltd.

Tel: 177-7179-1433 17771741533
Fax: 027-62437337
Email: 1228159977@qq.com
Country: China
ProdList: 1298
Advantage: 58

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View Lastest Price from OLSALAZINE manufacturers

Sinoway Industrial co., ltd.

Product: Olsalazine 15722-48-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20tons
Release date: 2025-04-01

Career Henan Chemical Co

Product: OLSALAZINE 15722-48-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

15722-48-2, OLSALAZINERelated Search:

D-Glucurone Anastrozole Olsalazine sodium EP Impurity B Omeprazole magnesium Magnesium trisilicate 6-Mercaptopurine 5-Aminosalicylic acid 3,3'-DIMETHYLAZOBENZENE OLSALAZINE Olsalazine sodium OLSALAZINE SODIUM FOR PERFORMANCE TEST olsalazine-O-sulfate 3,3'-AZODIBENZOIC ACID Sodium olsalazine OLSALAZINE HCL Olsalazine(Dipentum)

Ph-CJ-91B

4,4'-Dihydroxyazobenzene-3,3'-dicarboxylic acid

5,5'-Azodisalicylic acid

3,3'-(1,2-diazenediyl)bis[6-hydroxy-Benzoic acid

OLSALAZINE

3,3’-azobis(6-hydroxy-benzoicaci

3,3’-azobis(6-hydroxybenzoicacid)

5,5’-azobis(salicylicacid)

azodisal

c.i.mordantyellow5

Olsalazine-13C6

5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoic acid)

Benzoic acid, 3,3'-(1,2-diazenediyl)bis[6-hydroxy-

OLSALAZINE USP/EP/BP

Olsalazine 13C12

Olsalazine D6

OlsalazineQ: What is Olsalazine Q: What is the CAS Number of Olsalazine Q: What is the storage condition of Olsalazine

OLSALAZINE 15722-48-2

Dipentium

Leukotriene Receptor,Olsalazine,ulcerative colitis,Inhibitor,inhibit,PMNL,Anti-inflammatory,MNL

5-[(3-carboxy-4-hydroxyphenyl)diazenyl]-2-hydroxybenzoic acid

Olsalazine, 10 mM in DMSO

(Z)-5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoic acid)

15722-48-2