Treatment of acute and chronic colitis Adverse reaction
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Olsalazine sodium

Treatment of acute and chronic colitis Adverse reaction
Product Name
Olsalazine sodium
CAS No.
6054-98-4
Chemical Name
Olsalazine sodium
Synonyms
CJ-91B;Dipentum;Osazaline;C.I. 14130;Azodisal Sodium;Chrome Yellow AS;Mordant Yellow 5;OLSALAZINE SODIUM;OLSALAZINE DISODIUM;Olsalazine sodium CRS
CBNumber
CB7197367
Molecular Formula
C14H8N2O6.2Na
Formula Weight
346.2
MOL File
6054-98-4.mol
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Olsalazine sodium Property

Melting point:
240 °C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Sparingly soluble in water, soluble in dimethyl sulfoxide, very slightly soluble in methanol.
form 
neat
CAS DataBase Reference
6054-98-4(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt (6054-98-4)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O0146010
Product name
Olsalazine sodium for performance test
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
o0146010
Price
$183
Updated
2019/12/02
Sigma-Aldrich
Product number
O0146000
Product name
Olsalazine sodium
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
o0146000
Price
$190
Updated
2020/08/18
Sigma-Aldrich
Product number
O0146000
Product name
Olsalazine sodium
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
TCI Chemical
Product number
O0517
Product name
Olsalazine Sodium
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$54
Updated
2021/03/22
TCI Chemical
Product number
O0517
Product name
Olsalazine Sodium
Purity
>98.0%(HPLC)
Packaging
1g
Price
$154
Updated
2021/03/22
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Olsalazine sodium Chemical Properties,Usage,Production

Treatment of acute and chronic colitis

Olsalazine sodium is a drug developed by Pharmacia A B Co., Switzerland, to treat acute and chronic colitis. It was first listed in Denmark in 1989. It has been collected and recordedby the European Pharmacopoeia 7 edition and the national drug standard WS1(X-349) -2004Z. Orsalazine sodium is a precursor drug consisting of two azo bonds linked to 5amino salicylic acid. The bacteria in the colon break up the diazo bond and release 5amino salicylic acid. 5amino salicylic acid acts on colitis mucosa, inhibits the formation of prostaglandins, leukotrienes and other inflammatory factors, and reduces membrane permeability, and plays a role in the treatment of ulcerative colitis. This product weakens the absorption of nitrogen, sodium and water in the ileum and colonic mucosa, which is transformed into secretion in human body. Patients with ulcerative colitis take 1g daily, and the whole intestinal transit time is shortened by 40%.  If the healthy subjects are given oral administration of 2g once, It has no effect on the complex frequency of migration of the small intestine. But it can cause diarrhea in 30% of the users and increase the diarrhea of the patients with intestinal inflammation.  The bioavailability of the whole body is extremely low. The absorption rate of the oral dose is less than 5%.
After absorption, about 10% doses will be conjugated to orsalazine sulfate, t1/2 about 1H and conjugated half life is about 7 days.
Figure 1 The structural formula of oralalazine sodium

Adverse reaction

The most common side effect is diarrhoea, the incidence of which is 17%. Usually, the difference between diarrhea and intestinal inflammation is that the excreta has high water content without blood, and is related to the dosage. It usually occurs when the treatment begins or the dose increases. Reduction the dose of this product or combined use with Loperamide, diarrhea will be controlled. Other side effects include headache, nausea, abdominal pain, rash, dizziness and joint pain. Most of the patients who are allergic or intolerant to sulfasalazine are resistant to this product. The male sterility treated with sulfasalazine improved after using this product.

Chemical Properties

Yellow Crystalline Powder

Uses

Dimer of Mesalamine. It is an anti-inflammatorydrug used in the treatment of inflammatory bowel disease and ulcerative colitis

Uses

Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.

Uses

Mordant dye for wool.

Preparation

5-Amino-2-chlorobenzoic acid diazotization, coupled with 2-Hydroxybenzoic acid, and then in a certain pressure and contains trace copper powder or Cupric oxide of Sodium hydroxide solution common heating (130 ~ 150 ℃).

Definition

ChEBI: An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical

brand name

Dipentum (UCB).

Properties and Applications

deep green light yellow. Soluble in water for green light yellow, moderate soluble in Etanol for green yellow. In concentrated sulfuric acid for yellow orange, dilution after light yellow, In concentrated nitric acid to red. Dye aqueous solution to join concentrated hydrochloric acid color greatly shallow for yellow; Join concentrated Sodium hydroxide solution for golden orange.

Standard Ironing Fastness Light Fastness Fulling Persperation Fastness Soaping Water
Alkali Acid
ISO 4-5 6 4-5 2-3 4-5 5 5
AATCC 5 6-7 4 5 5 5

Olsalazine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Olsalazine sodium Suppliers

Liaoning Nirvana Pharmaceutical Co., Ltd.
Tel
--
Fax
--
Email
office@lnnvn.com
Country
China
ProdList
4
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60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43504
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61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
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70
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
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64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
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50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8933
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Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2950
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ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847-
Fax
021-55068248
Email
3008007399@qq.com
Country
China
ProdList
4995
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60
Haoyuan Chemexpress Co., Ltd.
Tel
86-21-58998985
Fax
(86) 21-58955996
Email
apisales@chemexpress.com.cn
Country
China
ProdList
7557
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View Lastest Price from Olsalazine sodium manufacturers

Baoji Guokang Healthchem co.,ltd
Product
Olsalazine sodium 6054-98-4
Price
US $1000.00/KG
Min. Order
1公斤
Purity
99%
Supply Ability
1TON
Release date
2021-06-07
Dideu Industries Group Limited
Product
Olsalazine sodium USP/EP/BP 6054-98-4
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-02
Shaanxi Dideu Medichem Co. Ltd
Product
Olsalazine sodium 6054-98-4
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30

6054-98-4, Olsalazine sodiumRelated Search:


  • 3,3’-azobis[6-hydroxy-benzoicacidisodiumsalt
  • 5,5'-Azobis(2-hydroxybenzoic acid sodium) salt
  • 5,5'-Azobissalicylic acid disodium salt
  • Olsalazine sodium, >=98%
  • Benzoic acid, 3,3-(1,2-diazenediyl)bis[6-hydroxy-, sodium salt (1:2)
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  • OLSALAZINE DISODIUM
  • OLSALAZINE SODIUM
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  • Chrome Yellow AS
  • Mordant Yellow 5
  • Osazaline
  • 3,3Azobis(6-hydroxybenzoic Acid) Sodium Salt
  • Azodisal Sodium
  • C.I. 14130
  • CJ-91B
  • Dipentum
  • Disodium Azodisalicylate
  • Olsalazine Sodium Salt
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  • Mordant yellow 5 sodium salt (C.I. 14130)
  • Olsalazine sodium for performance test CRS
  • Olsalazine sodium CRS
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  • Disodium 5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoate)
  • Olsalazine sodium USP/EP/BP
  • C.I.Mordant Yellow 5:C.I.14130
  • 6054-98-4
  • C14H8N2Na2O6
  • C14H10Na2O6
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  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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  • API
  • AZODISAL SODIUM