ChemicalBook > CAS DataBase List > Olsalazine sodium

Olsalazine sodium

Treatment of acute and chronic colitis Adverse reaction

Product Name: Olsalazine sodium
CAS No.: 6054-98-4
Chemical Name: Olsalazine sodium
Synonyms: CJ-91B;Dipentum;Osazaline;C.I. 14130;Azodisal Sodium;Chrome Yellow AS;Mordant Yellow 5;OLSALAZINE SODIUM;OLSALAZINE DISODIUM;Olsalazine sodium CRS
CBNumber: CB7197367
Molecular Formula: C14H11N2NaO6
Formula Weight: 326.24
MOL File: 6054-98-4.mol

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Olsalazine sodium Property

Melting point:: 240 °C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Sparingly soluble in water, soluble in dimethyl sulfoxide, very slightly soluble in methanol.
form: Solid
color: Light Yellow to Yellow
Water Solubility: H2O: 2mg/mL, clear
InChI: InChI=1S/C14H10N2O6.Na.H/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/b16-15+;;
InChIKey: DUGBQTHDGWSMAJ-VRZXRVJBSA-N
SMILES: N(/C1C=CC(O)=C(C(=O)O)C=1)=N\C1C=CC(O)=C(C(=O)O)C=1.[NaH]
CAS DataBase Reference: 6054-98-4(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt (6054-98-4)

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Safety

HS Code: 2927.00.5000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O0146010
Product name: Olsalazine sodium for performance test
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 60 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: O0146000
Product name: Olsalazine sodium
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 70 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: O0146010
Product name: Olsalazine sodium for performance test
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: o0146010
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: O0146000
Product name: Olsalazine sodium
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: o0146000
Price: $220
Updated: 2024/03/01

TCI Chemical

Product number: O0517
Product name: Olsalazine Sodium
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $60
Updated: 2025/07/31

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Olsalazine sodium Chemical Properties,Usage,Production

Treatment of acute and chronic colitis

Olsalazine sodium is a drug developed by Pharmacia A B Co., Switzerland, to treat acute and chronic colitis. It was first listed in Denmark in 1989. It has been collected and recordedby the European Pharmacopoeia 7 edition and the national drug standard WS1(X-349) -2004Z. Orsalazine sodium is a precursor drug consisting of two azo bonds linked to 5amino salicylic acid. The bacteria in the colon break up the diazo bond and release 5amino salicylic acid. 5amino salicylic acid acts on colitis mucosa, inhibits the formation of prostaglandins, leukotrienes and other inflammatory factors, and reduces membrane permeability, and plays a role in the treatment of ulcerative colitis. This product weakens the absorption of nitrogen, sodium and water in the ileum and colonic mucosa, which is transformed into secretion in human body. Patients with ulcerative colitis take 1g daily, and the whole intestinal transit time is shortened by 40%. If the healthy subjects are given oral administration of 2g once, It has no effect on the complex frequency of migration of the small intestine. But it can cause diarrhea in 30% of the users and increase the diarrhea of the patients with intestinal inflammation. The bioavailability of the whole body is extremely low. The absorption rate of the oral dose is less than 5%.
After absorption, about 10% doses will be conjugated to orsalazine sulfate, t1/2 about 1H and conjugated half life is about 7 days.

Figure 1 The structural formula of oralalazine sodium

Adverse reaction

The most common side effect is diarrhoea, the incidence of which is 17%. Usually, the difference between diarrhea and intestinal inflammation is that the excreta has high water content without blood, and is related to the dosage. It usually occurs when the treatment begins or the dose increases. Reduction the dose of this product or combined use with Loperamide, diarrhea will be controlled. Other side effects include headache, nausea, abdominal pain, rash, dizziness and joint pain. Most of the patients who are allergic or intolerant to sulfasalazine are resistant to this product. The male sterility treated with sulfasalazine improved after using this product.

Chemical Properties

Yellow Crystalline Powder

Uses

Dimer of Mesalamine. It is an anti-inflammatorydrug used in the treatment of inflammatory bowel disease and ulcerative colitis

Uses

Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.

Uses

Mordant dye for wool.

Preparation

5-Amino-2-chlorobenzoic acid diazotization, coupled with 2-Hydroxybenzoic acid, and then in a certain pressure and contains trace copper powder or Cupric oxide of Sodium hydroxide solution common heating (130 ~ 150 ℃).

Definition

ChEBI: An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical

brand name

Dipentum (UCB).

Biological Activity

Olsalazine is an anti-inflammatory drug used in inflammatory bowel disease and ulcerative colitis treatments. It is a pro-drug of 5-aminosalicylic acid (mesalamine) th at it is converted by the bacteria in the colon to mesalamine. Olsalazine (5-aminosalicylic acid) is consider as a broad-spectrum anticancer agent. Additionally, olsalazine increases both eEF1A2 and utrophin A levels in in C2C12 myoblasts (relevant to Duchenne muscular dystrophy).

Clinical Use

Induction and maintenance of remission in ulcerative colitis

Metabolism

Olsalazine is broken down by the colonic bacterial flora into 2 molecules of 5-aminosalicylic acid (mesalazine).
The small amounts (1-2% of the dose or less) of intact olsalazine that are absorbed are excreted mainly in urine.
Approximately 0.1% of an oral dose of olsalazine is hepatically metabolised to olsalazine-O-sulfate (olsalazine-S), which has a half-life of 7 days.

Properties and Applications

deep green light yellow. Soluble in water for green light yellow, moderate soluble in Etanol for green yellow. In concentrated sulfuric acid for yellow orange, dilution after light yellow, In concentrated nitric acid to red. Dye aqueous solution to join concentrated hydrochloric acid color greatly shallow for yellow; Join concentrated Sodium hydroxide solution for golden orange.

Standard	Ironing Fastness	Light Fastness	Fulling		Persperation Fastness	Soaping	Water
Standard	Ironing Fastness	Light Fastness	Alkali	Acid	Persperation Fastness	Soaping	Water
ISO	4-5	6	4-5	2-3	4-5	5	5
AATCC	5	6-7	4		5	5	5

Olsalazine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Olsalazine sodium manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: Olsalazine sodium 6054-98-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-07

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Olsalazine sodium 6054-98-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-07

Shaanxi Dideu New Materials Co. Ltd

Product: Olsalazine sodium 6054-98-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

6054-98-4, Olsalazine sodiumRelated Search:

5-Aminosalicylic acid Isopropylparaben Diethyl azodicarboxylate 4-PHENYLAZOPHENOL Cefodizime Diisopropyl azodicarboxylate Disodium edetate dihydrate Ethylenediaminetetraacetic acid disodium salt OLSALAZINE Butylparaben 3-Hydroxybenzoic acid Methylparaben 2,2'-Azobis(2,4-dimethyl)valeronitrile Salicylic acid 4-Hydroxybenzoic acid 2'-Hydroxy-3-phenylpropiophenone 2,2'-Azobis(2-methylpropionitrile) Formoterol fumarate

3,3’-azobis[6-hydroxy-benzoicacidisodiumsalt

5,5'-Azobis(2-hydroxybenzoic acid sodium) salt

5,5'-Azobissalicylic acid disodium salt

Olsalazine sodium, >=98%

Benzoic acid, 3,3-(1,2-diazenediyl)bis[6-hydroxy-, sodium salt (1:2)

4,4′-Dihydroxyazobenzene-3,3′-dicarboxylic acid disodium salt

5,5′-Azobis(salicylic acid, sodium salt)

Benzoicacid,3,3’-azobis[6-hydroxy-,disodiumsalt

olsalazinedisodiumsalt

OLSALAZINE DISODIUM

OLSALAZINE SODIUM

disodium 5,5'-azodisalicylate

Acid mordant Yellow 5

Chrome Yellow AS

Mordant Yellow 5

Osazaline

3,3Azobis(6-hydroxybenzoic Acid) Sodium Salt

Azodisal Sodium

C.I. 14130

CJ-91B

Dipentum

Disodium Azodisalicylate

Olsalazine Sodium Salt

3,3'-azobis(6-hydroxy-benzoic acid) disodium salt

Mordant yellow 5 sodium salt (C.I. 14130)

Olsalazine sodium for performance test CRS

Olsalazine sodium CRS

Sodium 5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoate)

Disodium 5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoate)

Olsalazine sodium USP/EP/BP

C.I.Mordant Yellow 5:C.I.14130

Olsalazine Sodium (CJ-91B)

Olsalazine sodium for performance test (O0146010)

Olsalazine disodium, 10 mM in DMSO

6054-98-4

C14H8N2Na2O6

C14H10Na2O6

C14H8N2O62Na

Intermediates & Fine Chemicals

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AZODISAL SODIUM