Formoterol fumarate
- Product Name
- Formoterol fumarate
- CAS No.
- 43229-80-7
- Chemical Name
- Formoterol fumarate
- Synonyms
- Aformoterol;FORMOTEROL HEMIFUMARATE;YM 08316;FarMeterol;CGP 25827A;NSC 299587;CGP-25827A-e;Fumarate dihydrate;FORMAMIDE FUMARATE;FORADIL;FORMOTEROL
- CBNumber
- CB5689602
- Molecular Formula
- C42H52N4O12
- Formula Weight
- 804.88
- MOL File
- 43229-80-7.mol
Formoterol fumarate Property
- Melting point:
- 138-140°C
- storage temp.
- Room temperature
- solubility
- Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
- pka
- pKa1 7.9; pKa2 9.2(at 25℃)
- color
- White to off-white
- λmax
- 284nm(lit.)
- Merck
- 14,4245
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- RIDADR
- 3249
- RTECS
- LQ2988000
- HazardClass
- 6.1(b)
- PackingGroup
- II
- Toxicity
- LD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H370Causes damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- Y0000339
- Product name
- Formoterol for impurity I identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000339
- Price
- $153
- Updated
- 2024/03/01
- Product number
- Y0000340
- Product name
- Formoterol fumarate for system suitability
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000340
- Price
- $218
- Updated
- 2023/01/07
- Product number
- 15584
- Product name
- Formoterol (hemifumarate)
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 15584
- Product name
- Formoterol (hemifumarate)
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $352
- Updated
- 2021/12/16
- Product number
- 1448
- Product name
- Formoterolhemifumarate
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $162
- Updated
- 2021/12/16
Formoterol fumarate Chemical Properties,Usage,Production
Description
Formoterol fumarate is a β2-selective adrenergic agonist useful in the treatment of bronchial asthma. It s potency and duration of action a r e reported to exceed those of salbutamol, as is its ability to inhibit allergic and non-allergic histamine release.
Chemical Properties
Crystalline Solid
Originator
Yarnanouchi (Japan)
Uses
Formoterol fumarate is a potent β2-AR agonist.
Uses
antiasthmatic;?2-agonist
Uses
long-acting β 2-agonist, anti-asthmatic
Uses
A selective 2-adrenergic receptor agonist. Used as an antiasthmatic
Definition
ChEBI: (S,S)-formoterol fumarate is a fumarate salt prepared from (S,S)-formoterol by reaction of one molecule of fumaric acid for every two molecules of (S,S)-formoterol. It contains a (S,S)-formoterol(1+). It is an enantiomer of an arformoterol fumarate.
brand name
Foradil (Novartis);ATOCK.
Mechanism of action
This is believed to result from formoterol's greater water solubility, allowing it to get to the receptor sites faster, whereas its moderate lipophilicity keeps it in the lungs longer. It is indicated for the long-term maintenance treatment of asthma and for patients with symptoms of nocturnal asthma who require regular treatment with inhaled, short-acting, β2-agonists. It is not indicated for patients whose asthma can be managed by occasional use of inhaled, short-acting, β2-agonists. Formoterol is available only as a powder in a capsule for administration via the aerosolizer. Patients should be cautioned not to take the capsules orally and to keep them in a safe place to avoid accidental oral administration.
Clinical Use
Formoterol has a β-directing N-isopropyl-p-methoxyphenyl group and a unique m-formamide and p-hydroxyphenyl ring, which provides selectivity for β2-receptors. It is resistant to MAO and COMT, making it a long-acting agonist. Formoterol has a more rapid onset as compared to salmeterol while maintaining the same long duration of action.
storage
Store at RT
References
1) Anderson et al. (1993), Formoterol: pharmacology, molecular basis of agonism and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator; Life Sciences, 52 2145 2) Teng et al. (2005), Structure-activity relationship study of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett., 15 5039 3) Noguchi et al. (2015), Effect of beta2-adrenergic agonist on eosinophil adhesion, superoxide anion generation, and degranulation; Allergol. Int., 64 S46 4)Busquets et al. (2004), Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting; Cancer Res., 64 6725 5) O’Neill et al. (2020), Pharmacological targeting of ?2-adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson’s disease; Br. J. Pharmacol., 177 282
Formoterol fumarate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Formoterol fumarate manufacturers
- Product
- Formoterol Fumarate Anhydrous 43229-80-7
- Price
- US $0.00/g/Bag
- Min. Order
- 10g
- Purity
- 98.5%min; JP14
- Supply Ability
- 20kg/month
- Release date
- 2021-06-03
- Product
- Formoterol Hemifumarate 43229-80-7
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-28
- Product
- Formoterol fumarate 43229-80-7
- Price
- US $133.00/g/Bag
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2021-06-04