Treatment of acute and chronic colitis Adverse reaction
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Olsalazine sodium

Treatment of acute and chronic colitis Adverse reaction
Product Name
Olsalazine sodium
CAS No.
6054-98-4
Chemical Name
Olsalazine sodium
Synonyms
CJ-91B;Dipentum;Osazaline;C.I. 14130;Azodisal Sodium;Chrome Yellow AS;Mordant Yellow 5;OLSALAZINE SODIUM;OLSALAZINE DISODIUM;Olsalazine sodium CRS
CBNumber
CB7197367
Molecular Formula
C14H11N2NaO6
Formula Weight
326.24
MOL File
6054-98-4.mol
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Olsalazine sodium Property

Melting point:
240 °C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Sparingly soluble in water, soluble in dimethyl sulfoxide, very slightly soluble in methanol.
color 
Light Yellow to Yellow
CAS DataBase Reference
6054-98-4(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt (6054-98-4)
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Safety

HS Code 
2927.00.5000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O0146010
Product name
Olsalazine sodium for performance test
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
o0146010
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
O0146000
Product name
Olsalazine sodium
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
o0146000
Price
$220
Updated
2024/03/01
TCI Chemical
Product number
O0517
Product name
Olsalazine Sodium
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$60
Updated
2024/03/01
TCI Chemical
Product number
O0517
Product name
Olsalazine Sodium
Purity
>98.0%(HPLC)
Packaging
1g
Price
$171
Updated
2024/03/01
Cayman Chemical
Product number
23661
Product name
Olsalazine (sodium salt)
Purity
≥98%
Packaging
250mg
Price
$49
Updated
2024/03/01
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Olsalazine sodium Chemical Properties,Usage,Production

Treatment of acute and chronic colitis

Olsalazine sodium is a drug developed by Pharmacia A B Co., Switzerland, to treat acute and chronic colitis. It was first listed in Denmark in 1989. It has been collected and recordedby the European Pharmacopoeia 7 edition and the national drug standard WS1(X-349) -2004Z. Orsalazine sodium is a precursor drug consisting of two azo bonds linked to 5amino salicylic acid. The bacteria in the colon break up the diazo bond and release 5amino salicylic acid. 5amino salicylic acid acts on colitis mucosa, inhibits the formation of prostaglandins, leukotrienes and other inflammatory factors, and reduces membrane permeability, and plays a role in the treatment of ulcerative colitis. This product weakens the absorption of nitrogen, sodium and water in the ileum and colonic mucosa, which is transformed into secretion in human body. Patients with ulcerative colitis take 1g daily, and the whole intestinal transit time is shortened by 40%.  If the healthy subjects are given oral administration of 2g once, It has no effect on the complex frequency of migration of the small intestine. But it can cause diarrhea in 30% of the users and increase the diarrhea of the patients with intestinal inflammation.  The bioavailability of the whole body is extremely low. The absorption rate of the oral dose is less than 5%.
After absorption, about 10% doses will be conjugated to orsalazine sulfate, t1/2 about 1H and conjugated half life is about 7 days.

Figure 1 The structural formula of oralalazine sodium

Adverse reaction

The most common side effect is diarrhoea, the incidence of which is 17%. Usually, the difference between diarrhea and intestinal inflammation is that the excreta has high water content without blood, and is related to the dosage. It usually occurs when the treatment begins or the dose increases. Reduction the dose of this product or combined use with Loperamide, diarrhea will be controlled. Other side effects include headache, nausea, abdominal pain, rash, dizziness and joint pain. Most of the patients who are allergic or intolerant to sulfasalazine are resistant to this product. The male sterility treated with sulfasalazine improved after using this product.

Chemical Properties

Yellow Crystalline Powder

Uses

Dimer of Mesalamine. It is an anti-inflammatorydrug used in the treatment of inflammatory bowel disease and ulcerative colitis

Uses

Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.

Uses

Mordant dye for wool.

Preparation

5-Amino-2-chlorobenzoic acid diazotization, coupled with 2-Hydroxybenzoic acid, and then in a certain pressure and contains trace copper powder or Cupric oxide of Sodium hydroxide solution common heating (130 ~ 150 ℃).

Definition

ChEBI: An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical

brand name

Dipentum (UCB).

Clinical Use

Induction and maintenance of remission in ulcerative colitis

Metabolism

Olsalazine is broken down by the colonic bacterial flora into 2 molecules of 5-aminosalicylic acid (mesalazine).
The small amounts (1-2% of the dose or less) of intact olsalazine that are absorbed are excreted mainly in urine.
Approximately 0.1% of an oral dose of olsalazine is hepatically metabolised to olsalazine-O-sulfate (olsalazine-S), which has a half-life of 7 days.

Properties and Applications

deep green light yellow. Soluble in water for green light yellow, moderate soluble in Etanol for green yellow. In concentrated sulfuric acid for yellow orange, dilution after light yellow, In concentrated nitric acid to red. Dye aqueous solution to join concentrated hydrochloric acid color greatly shallow for yellow; Join concentrated Sodium hydroxide solution for golden orange.

Standard Ironing Fastness Light Fastness Fulling Persperation Fastness Soaping Water
Alkali Acid
ISO 4-5 6 4-5 2-3 4-5 5 5
AATCC 5 6-7 4 5 5 5

Olsalazine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Olsalazine sodium Suppliers

TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23680
Advantage
75
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View Lastest Price from Olsalazine sodium manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Olsalazine sodium 6054-98-4
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Olsalazine sodium 6054-98-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-07
Baoji Guokang Healthchem co.,ltd
Product
Olsalazine sodium 6054-98-4
Price
US $1000.00/KG
Min. Order
1公斤
Purity
99%
Supply Ability
1TON
Release date
2021-06-07

6054-98-4, Olsalazine sodiumRelated Search:


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  • Intermediates & Fine Chemicals
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