ChemicalBook > CAS DataBase List > 2,6-Dibromo-4-methoxypyridine

2,6-Dibromo-4-methoxypyridine

Product Name
2,6-Dibromo-4-methoxypyridine
CAS No.
117873-72-0
Chemical Name
2,6-Dibromo-4-methoxypyridine
Synonyms
2,6-Dibromo-4-methoxypyridine;Pyridine,2,6-dibromo-4-methoxy-;2,6-Dibromo-4-methoxypyridine 99%
CBNumber
CB22129769
Molecular Formula
C6H5Br2NO
Formula Weight
266.92
MOL File
117873-72-0.mol
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2,6-Dibromo-4-methoxypyridine Property

Melting point:
136 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point:
283.0±35.0 °C(Predicted)
Density 
1.919±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
crystalline solid
pka
-2.35±0.10(Predicted)
color 
Lemon
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D426623
Product name
2,6-Dibromo-4-methoxypyridine
Packaging
100mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-9-2M
Product name
2,6-Dibromo-4-methoxypyridine
Packaging
1g
Price
$90
Updated
2021/12/16
Oakwood
Product number
321417
Product name
2,6-Dibromo-4-methoxypyridine
Purity
97%
Packaging
1g
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD55742
Product name
2,6-Dibromo-4-methoxypyridine
Packaging
250mg
Price
$105
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD55742
Product name
2,6-Dibromo-4-methoxypyridine
Packaging
500mg
Price
$165
Updated
2021/12/16
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2,6-Dibromo-4-methoxypyridine Chemical Properties,Usage,Production

Uses

2,6-Dibromo-4-methoxypyridine is a useful reactant for the preparation of various organic compounds such as pyridine-pyridone alternate oligomers, and cyclic adenosine monophosphate.

Synthesis

2408-70-0

124-41-4

117873-72-0

Reaction of 2,4,6-tribromopyridine (5) and sodium methanol (1.2 eq.) under methanol reflux conditions afforded 2,6-dibromo-4-methoxypyridine (6) in 80% yield. Subsequently, the compound (6) was treated with n-butyllithium (1.2 eq.) at -78 °C and reacted with pivaleronitrile (1.2 eq.) for 150 min, followed by refluxing in two conventional sulfuric acids for 2 h to afford the keto isomer (7) in 86% yield. Compound (7) was converted to optically active alcohol (8) in 93% yield and 90% optical purity by hydrogen transfer type asymmetric reduction catalyzed by asymmetric ruthenium catalyst RuCl[(S,S)-Tddpen] (p-isopropylbenzene, 0.01 equiv.) using formic acid (4.3 equiv.) and triethylamine (2.5 equiv.). Next, compound (8) was converted to a camphor ester using a chloride, processed for optical splitting by recrystallization (75% yield, diastereoisomer ratio = 99/<1), and saponified again to give an almost optically pure alcohol (7, quantitatively). Finally, homogeneous coupling of compound (7) using palladium catalyst [PdCl2(PhCN)2-TDAE] afforded the pyridine isomer (9) (chemical formula 5) in 36% yield (diastereoisomer ratio = >99.5/<0.5).

References

[1] Patent: EP1724251, 2006, A1. Location in patent: Page/Page column 5; 9

2,6-Dibromo-4-methoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Dibromo-4-methoxypyridine Suppliers

China 62 India 3 United Kingdom 2 United States 7 Global 74
Accela ChemBio Inc.
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+1-858-6993322
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(+1)-858-876-1948
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Alchem Pharmtech,Inc.
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sales@alchempharmtech.com
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Aladdin Scientific
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Synthonix Inc
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SynQuest Laboratories, Inc.
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Frontier Scientific, Inc.
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Matrix Scientific
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View Lastest Price from 2,6-Dibromo-4-methoxypyridine manufacturers

Career Henan Chemical Co
Product
2,6-Dibromo-4-methoxypyridine 117873-72-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-07

117873-72-0, 2,6-Dibromo-4-methoxypyridineRelated Search:

2-BROMO-4-HYDROXYPYRIDINE 2-Bromo-4-methoxypyridine 2,6-Dibromo-4-methoxypyridine 2,3,6-TRIBROMO-4-METHOXY-5-NITROPYRIDINE

  • 2,6-Dibromo-4-methoxypyridine
  • Pyridine,2,6-dibromo-4-methoxy-
  • 2,6-Dibromo-4-methoxypyridine 99%
  • 117873-72-0