ChemicalBook > CAS DataBase List > 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

Product Name: 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether
CAS No.: 16627-68-2
Chemical Name: 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether
Synonyms: 1,1,2,2-TETRAFLUOROETHYL 2,2,3,3-TETRAFLUOROPROPYL ETHER;1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane;uoropropyL;DAIKIN T-5216;HFE458 HFE-458;1,1,2,2-TetrafL;2,2,3,3-tetrafL;HYDROFLUOROETHER-458;2-Tetrafluoroethyl-2;3-tetrafluoropropylether
CBNumber: CB2214179
Molecular Formula: C5H4F8O
Formula Weight: 232.07
MOL File: 16627-68-2.mol

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1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether Property

Boiling point:: 92 °C
Density: 1.533
refractive index: 1.29
Flash point:: 27.5 °C
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
Specific Gravity: 1.533
color: Colorless to Almost colorless
InChI: InChI=1S/C5H4F8O/c6-2(7)4(10,11)1-14-5(12,13)3(8)9/h2-3H,1H2
InChIKey: HCBRSIIGBBDDCD-UHFFFAOYSA-N
SMILES: C(F)(F)C(F)(F)COC(F)(F)C(F)F
CAS DataBase Reference: 16627-68-2(CAS DataBase Reference)
EPA Substance Registry System: (2H-Perfluoroethyl)(1H,1H,3H-perfluoropropyl)ether (16627-68-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 3271
HazardClass: IRRITANT
PackingGroup: II
HS Code: 29091990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3069
Product name: 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether
Purity: >98.0%(GC)
Packaging: 5g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: T3069
Product name: 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether
Purity: >98.0%(GC)
Packaging: 25g
Price: $57
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK246778
Product name: 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether
Packaging: 5g
Price: $68
Updated: 2021/12/16

Oakwood

Product number: 010635
Product name: 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether
Packaging: 100g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 5332AD
Product name: 1,1,2,2-Tetrafluoroethyl 2,2,3,3-Tetrafluoropropyl Ether
Packaging: 25g
Price: $79
Updated: 2021/12/16

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1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether Chemical Properties,Usage,Production

Description

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (HFE-458) is a hydrofluoroether. Hydrofluoroether is a new type of chlorofluorocarbons (CFCs) substitute, ODP is zero, GWP is low, and the atmospheric residence time is very short. It is considered as one of the ideal substitutes for CFCs.

Uses

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

A system of a 6-L autoclave made of stainless steel was evacuated. The autoclave was charged with 401 g of potassium hydroxide (7.15 mol, 0.55 molar amount relative to 1 mol of a fluorine-containing alkyl alcohol), water (1604 mL), 2,2,3,3-tetrafluoro-1-propanol (boiling point of 109?? C., specific gravity of 1.4) represented by HCF2CF2CH2OH (1716 g, 13 mol) as a fluorine-containing alkyl alcohol. Then, the system was evacuated and replaced with nitrogen 20 times at room temperature. After evacuated, the system was filled with tetrafluoroethylene to 0.1 MPa, and the reaction system was heated to 85?? C. After the temperature in the system reached 85?? C., tetrafluoroethylene was added thereto little by little so that the reaction pressure was kept at 0.5 to 0.8 MPa. The temperature in the system was adjusted so as to be kept at 75 to 95?? C.Tetrafluoroethylene was added until the amount reached 0.5 molar relative to 1 mol of the fluorine-containing alkyl alcohol. The reaction was continuously carried out under stirring. When reduction in the pressure in the autoclave was stopped, the temperature in the autoclave was reduced to room temperature and unreacted tetrafluoroethylene was discharged, and the reaction was stopped. These steps took 5 hours to perform.The fluoroether of a lower phase of the production solution was HCF2CF2CH2OCF2CF2H (boiling point of 92?? C., specific gravity of 1.52). Table 1 shows the composition of the fluoroether production solution of a lower phase resulting from GC analysis.

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether manufacturers

Changyi Longchang Bio-Chemical Co., LTD

Product: CHLUMOFIUOR? CH-458 Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether 16627-68-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-04-09

Shenzhen Huayi Brothers Technology Co.,Ltd

Product: 1,1,2,2-tetrafluoroethyl-2,3,3-tetrafluoropropane ether HFE-458 16627-68-2
Price: US $0.00-0.00/kg
Min. Order: 25kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-11-19

Hebei Chuanghai Biotechnology Co,.LTD

Product: 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether 16627-68-2
Price: US $100.00-50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

16627-68-2, 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropyletherRelated Search:

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2,2,3,3-TETRAFLUORO-1-(1,1,2,2-TETRAFLUOROETHOXY)PROPANE

1,1,2,2-TETRAFLUOROETHYL 2,2,3,3-TETRAFLUOROPROPYL ETHER

1,1,2,2,5,5,6,6-OCTAFLUORO-3-OXAHEXANE

product NaMe 2,2,3,3-Tetrafluoro-1-(1,1,2,2-tetrafluoroethoxy)propane

1,1,2,2,5,5,6,6-Octafluoro-3-oxahexane, 1,1,2,2-Tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane

2H-Tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether

HYDROFLUOROETHER(HFE-458)

DAIKIN T-5216

Propane,1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)-

1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane

2H-Tetrafluoroethyl 2,2,3,3-tetrafluoropropyl ether 98%

HYDROFLUOROETHER-458

HFE-458 /1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

1,1,2,2-TetrafL

2,2,3,3-tetrafL

uoropropyL

1,1,2,2-Tetrafluoroethyl-2,2,3,3-Tetrafluoropropylether,>98%

2-Tetrafluoroethyl-2

3-tetrafluoropropylether

HFE458 HFE-458

1,1,2,2-tetrafluoroethyl-2,3,3-tetrafluoropropane ether HFE-458

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether HFE-458

2,2,3,3-Tetrafluoro-1-(1,1,2,2-tetrafluoroethoxy)propan

1,1,1,2,2,3,3-Heptafluoro-3-(1,1,2,2,3,3,3-heptafluoropropoxy)propane

CHLUMOFIUOR CH-458 Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether

Tetrafluoropropyltetrafluoroethyl ether

16627-68-2