4-Bromo-2-fluorobenzyl bromide
- Product Name
- 4-Bromo-2-fluorobenzyl bromide
- CAS No.
- 76283-09-5
- Chemical Name
- 4-Bromo-2-fluorobenzyl bromide
- Synonyms
- à,4-dibromo-2-fluorotoluene;4,α-dibromo-2-fluorotoluene;4-Bromo-2-fluoroben bromide;4-BroMo-2-fluorobenl broMide;2-fluor-4-bromobenzyl bromide;4-BROMO-2-FLUOROBENZYL BROMIDE;4-Bromo-1-Fluorobenzyl Bromide;2-FLUORO-4-BROMOBENZYL BROMIDE;4-Bromo-2-fluorobenzylbromide97%;4-Bromo-2-fluorobenzyl bromide 97%
- CBNumber
- CB2217453
- Molecular Formula
- C7H5Br2F
- Formula Weight
- 267.92
- MOL File
- 76283-09-5.mol
4-Bromo-2-fluorobenzyl bromide Property
- Melting point:
- 33-36 °C (lit.)
- Boiling point:
- 126 °C (19 mmHg)
- Density
- 1.9094 (rough estimate)
- refractive index
- 1.5770 (estimate)
- Flash point:
- 126°C/9mm
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- Low Melting Solid
- color
- White to off-white
- Sensitive
- Lachrymatory
- BRN
- 4307676
- InChI
- InChI=1S/C7H5Br2F/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
- InChIKey
- XMHNLZXYPAULDF-UHFFFAOYSA-N
- SMILES
- C1(CBr)=CC=C(Br)C=C1F
- CAS DataBase Reference
- 76283-09-5(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 22-34-52/53-20/21/22
- Safety Statements
- 26-36/37/39-45-61
- RIDADR
- UN 2923 8/PG 3
- WGK Germany
- 2
- Hazard Note
- Corrosive/Lachrymatory
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 477559
- Product name
- 4-Bromo-2-fluorobenzyl bromide
- Purity
- 98%
- Packaging
- 5g
- Price
- $36.7
- Updated
- 2023/06/20
- Product number
- B1934
- Product name
- 4-Bromo-2-fluorobenzyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- B1934
- Product name
- 4-Bromo-2-fluorobenzyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- B692153
- Product name
- 4-Bromo-2-fluorobenzyl bromide
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B692153
- Product name
- 4-Bromo-2-fluorobenzyl bromide
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
4-Bromo-2-fluorobenzyl bromide Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Bromo-2-fluorobenzyl bromide may be used in the synthesis of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)indoline-2,3-dione.
General Description
4-Bromo-2-fluorobenzyl bromide is a substituted benzyl bromide. Its density is 1.9094g/ml at 25°C.
Synthesis
51436-99-8
76283-09-5
General procedure for the synthesis of 2-fluoro-4-bromobenzyl bromide from 2-fluoro-4-bromotoluene: N-bromosuccinimide (NBS, 1.07 g, 6.05 mmol) and azobisisobutyronitrile (AIBN, 83 mg, 0.50 mmol) were dissolved in carbon tetrachloride (CCl4, 10 mL), followed by addition of 2-fluoro-4-bromotoluene (1 g, 5.04 mmol). The reaction mixture was heated to reflux at 100 °C for 13 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the resulting solid was collected by filtration. The filtrate was extracted several times with carbon tetrachloride and water. The organic layers were combined and dried with anhydrous sodium sulfate to remove residual water. Subsequently, the organic layer was concentrated under reduced pressure to afford 4-bromo-1-(bromomethyl)-2-fluorobenzene (1.2 g, 4.47 mmol) in 89% yield. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 7.51-7.41 (m, 1H), 7.09 (d, J=9.0 Hz, 1H), 6.99 (d, J=8.2 Hz, 1H), 4.34 (s, 2H).
References
[1] Patent: US2015/259350, 2015, A1. Location in patent: Paragraph 0169; 1070
[2] Patent: KR101745741, 2017, B1. Location in patent: Paragraph 0268
[3] Patent: WO2014/76104, 2014, A1. Location in patent: Page/Page column 66
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 15, p. 2938 - 2945
[5] European Journal of Pharmaceutical Sciences, 2006, vol. 27, # 2-3, p. 188 - 193
4-Bromo-2-fluorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2-fluorobenzyl bromide Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-Bromo-2-fluorobenzyl bromide manufacturers
- Product
- 4-Bromo-2-fluorobenzyl bromide 76283-09-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 4-Bromo-2-fluorobenzyl bromide 76283-09-5
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-24
- Product
- 4-Bromo-2-fluorobenzyl bromide 76283-09-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200KG
- Release date
- 2019-08-30