ChemicalBook > CAS DataBase List > 4-Bromo-2-fluorobenzyl bromide

4-Bromo-2-fluorobenzyl bromide

Product Name
4-Bromo-2-fluorobenzyl bromide
CAS No.
76283-09-5
Chemical Name
4-Bromo-2-fluorobenzyl bromide
Synonyms
à,4-dibromo-2-fluorotoluene;4,α-dibromo-2-fluorotoluene;4-Bromo-2-fluoroben bromide;4-BroMo-2-fluorobenl broMide;2-fluor-4-bromobenzyl bromide;4-BROMO-2-FLUOROBENZYL BROMIDE;4-Bromo-1-Fluorobenzyl Bromide;2-FLUORO-4-BROMOBENZYL BROMIDE;4-Bromo-2-fluorobenzylbromide97%;4-Bromo-2-fluorobenzyl bromide 97%
CBNumber
CB2217453
Molecular Formula
C7H5Br2F
Formula Weight
267.92
MOL File
76283-09-5.mol
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4-Bromo-2-fluorobenzyl bromide Property

Melting point:
33-36 °C (lit.)
Boiling point:
126 °C (19 mmHg)
Density 
1.9094 (rough estimate)
refractive index 
1.5770 (estimate)
Flash point:
126°C/9mm
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Methanol
form 
Low Melting Solid
color 
White to off-white
Sensitive 
Lachrymatory
BRN 
4307676
InChI
InChI=1S/C7H5Br2F/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
InChIKey
XMHNLZXYPAULDF-UHFFFAOYSA-N
SMILES
C1(CBr)=CC=C(Br)C=C1F
CAS DataBase Reference
76283-09-5(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
22-34-52/53-20/21/22
Safety Statements 
26-36/37/39-45-61
RIDADR 
UN 2923 8/PG 3
WGK Germany 
2
Hazard Note 
Corrosive/Lachrymatory
HazardClass 
8
PackingGroup 
III
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
477559
Product name
4-Bromo-2-fluorobenzyl bromide
Purity
98%
Packaging
5g
Price
$36.7
Updated
2023/06/20
TCI Chemical
Product number
B1934
Product name
4-Bromo-2-fluorobenzyl Bromide
Purity
>98.0%(GC)
Packaging
5g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
B1934
Product name
4-Bromo-2-fluorobenzyl Bromide
Purity
>98.0%(GC)
Packaging
25g
Price
$96
Updated
2025/07/31
TRC
Product number
B692153
Product name
4-Bromo-2-fluorobenzyl bromide
Packaging
500mg
Price
$45
Updated
2021/12/16
TRC
Product number
B692153
Product name
4-Bromo-2-fluorobenzyl bromide
Packaging
2.5g
Price
$65
Updated
2021/12/16
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4-Bromo-2-fluorobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Bromo-2-fluorobenzyl bromide may be used in the synthesis of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)indoline-2,3-dione.

General Description

4-Bromo-2-fluorobenzyl bromide is a substituted benzyl bromide. Its density is 1.9094g/ml at 25°C.

Synthesis

51436-99-8

76283-09-5

General procedure for the synthesis of 2-fluoro-4-bromobenzyl bromide from 2-fluoro-4-bromotoluene: N-bromosuccinimide (NBS, 1.07 g, 6.05 mmol) and azobisisobutyronitrile (AIBN, 83 mg, 0.50 mmol) were dissolved in carbon tetrachloride (CCl4, 10 mL), followed by addition of 2-fluoro-4-bromotoluene (1 g, 5.04 mmol). The reaction mixture was heated to reflux at 100 °C for 13 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the resulting solid was collected by filtration. The filtrate was extracted several times with carbon tetrachloride and water. The organic layers were combined and dried with anhydrous sodium sulfate to remove residual water. Subsequently, the organic layer was concentrated under reduced pressure to afford 4-bromo-1-(bromomethyl)-2-fluorobenzene (1.2 g, 4.47 mmol) in 89% yield. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 7.51-7.41 (m, 1H), 7.09 (d, J=9.0 Hz, 1H), 6.99 (d, J=8.2 Hz, 1H), 4.34 (s, 2H).

References

[1] Patent: US2015/259350, 2015, A1. Location in patent: Paragraph 0169; 1070
[2] Patent: KR101745741, 2017, B1. Location in patent: Paragraph 0268
[3] Patent: WO2014/76104, 2014, A1. Location in patent: Page/Page column 66
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 15, p. 2938 - 2945
[5] European Journal of Pharmaceutical Sciences, 2006, vol. 27, # 2-3, p. 188 - 193

4-Bromo-2-fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-fluorobenzyl bromide Suppliers

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View Lastest Price from 4-Bromo-2-fluorobenzyl bromide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Bromo-2-fluorobenzyl bromide 76283-09-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Henan Fengda Chemical Co., Ltd
Product
4-Bromo-2-fluorobenzyl bromide 76283-09-5
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-24
Career Henan Chemical Co
Product
4-Bromo-2-fluorobenzyl bromide 76283-09-5
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200KG
Release date
2019-08-30

76283-09-5, 4-Bromo-2-fluorobenzyl bromideRelated Search:

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