Chelidamic acid

Product Name: Chelidamic acid
CAS No.: 138-60-3
Chemical Name: Chelidamic acid
Synonyms: 4-HYDROXYPYRIDINE-2,6-DICARBOXYLIC ACID;4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid;CHELIDAMIC ACID HYDRATE;4-HYDROXY-2,6-PYRIDINEDICARBOXYLIC ACID;4-Hydroxypyridine-2,6-dicarboxylic acid hydrate;4-Oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid;CheL;Nsc3983;AKOS 90653;idamic acid
CBNumber: CB2220457
Molecular Formula: C7H5NO5
Formula Weight: 183.12
MOL File: 138-60-3.mol

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Chelidamic acid Property

Melting point:: 265-270 °C
Boiling point:: 428.3±45.0 °C(Predicted)
Density: 1.726±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 1 M NH4OH: 50mg/mL, clear to slightly hazy
pka: 0.12±0.40(Predicted)
form: powder
color: brown
biological source: synthetic (organic)
BRN: 476229
InChI: InChI=1S/C7H5NO5/c9-3-1-4(6(10)11)8-5(2-3)7(12)13/h1-2H,(H,8,9)(H,10,11)(H,12,13)
InChIKey: XTLJJHGQACAZMS-UHFFFAOYSA-N
SMILES: C1(C(O)=O)NC(C(O)=O)=CC(=O)C=1
CAS DataBase Reference: 138-60-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 792748
Product name: Chelidamic acid
Packaging: 1g
Price: $18.01
Updated: 2025/07/31

Sigma-Aldrich

Product number: 22490
Product name: Chelidamic acid hydrate
Purity: ≥97.0% (dried material, T), ~1?mol/mol water
Packaging: 25g
Price: $152.5
Updated: 2025/07/31

TCI Chemical

Product number: C0821
Product name: Chelidamic Acid Monohydrate
Purity: >95.0%(T)
Packaging: 5g
Price: $78
Updated: 2025/07/31

TCI Chemical

Product number: C0821
Product name: Chelidamic Acid Monohydrate
Purity: >95.0%(T)
Packaging: 25g
Price: $226
Updated: 2025/07/31

Sigma-Aldrich

Product number: C8011
Product name: Chelidamic acid hydrate
Purity: ≥95%, powder
Packaging: 5g
Price: $315
Updated: 2025/07/31

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Chelidamic acid Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

Chelidamic acid hydrate has been used in eluent solution as a complexing additive in high-performance chelation ion chromatography (HPCIC) for speciation of iron. It has also been used as an organic ligand for the polyoxometalate (POM)-based lanthanoid hybrid compounds.

Biochem/physiol Actions

Among the most potent of the tested "conformationally restricted glutamate analogs" as an inhibitor of glutamate decarboxylase.

Synthesis

99-32-1

138-60-3

4-Oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid was synthesized from betulinic acid using a modified literature method. The specific operation was as follows: 425 mL of 30% ammonia solution (containing NH3 41.8 g, 0.21 mol) was slowly added dropwise to the reaction system at 0 °C, and the dropwise addition process was controlled to be completed within 1 hour. After the dropwise addition, the reaction mixture was stirred continuously at room temperature for 48 hours. Upon completion of the reaction, the excess ammonia solution was removed by distillation under reduced pressure. Subsequently, the residue was mixed with 50 mL of water, activated carbon was added and decolorized by refluxing for 15 minutes. After hot filtration, the filtrate was collected and, after being cooled to room temperature, the pH was adjusted with a 37% aqueous hydrochloric acid solution to 1. At this point, a white solid precipitated from the solution, which was collected by filtration, washed several times with cold water, and finally dried under vacuum for 16 h. The target compound, 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid (13), was obtained as a white solid in a yield of 42 g with 98% yield.

Advantages

Chelidamic acid (1,4-dihydro-4-oxopyridine-2,6- dicarboxylic acid, CDA) is an organic material with great potential for accepting alkaline ions. It could be used as the anode material in LIBs. The new materials offer high capacity, superior cycle retention, favourable rate capability, and interesting electrochemical behaviours[1].

References

[1] Fu-Ming Wang*. “Synthesis and Characterization of Chelidonic Acid and Chelidamic Acid as Organic Anode Materials for Energy Storage.” ACS Sustainable Chemistry & Engineering 9 36 (2021): 12286–12299.

Chelidamic acid Preparation Products And Raw materials

Raw materials

Sodium nitrite Potassium permanganate 2,6-DIMETHYL-PYRIDIN-4-YLAMINE Sulfuric acid

Preparation Products

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Chelidamic acid Suppliers

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View Lastest Price from Chelidamic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Chelidamic acid 138-60-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-02

Shaanxi Dideu Medichem Co. Ltd

Product: Chelidamic acid 138-60-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Henan Fengda Chemical Co., Ltd

Product: chelidamic acid 138-60-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

138-60-3, Chelidamic acidRelated Search:

Chelidonic acid monohydrate Chelidonic acid Chelidamic acid 5-HYDROXYPYRIDINE-3,4-DICARBOXYLIC ACID METHYL ESTER,5-Hydroxypyridine-3,4-dicarboxylic acid 4-methyl ester CHELIDAMIC ACID MONOHYDRATE, 98 Chrysene 4-Methoxypyridine-2,6-dicarboxylic acid Diethyl 4-ethoxy-2,6-pyridinedicarboxylate 6-Methyl-5-hydroxypyridine-3,4-dicarboxylic acid Dimethyl 4-methoxy-2,6-Pyridinedicarboxylate 5-Hydroxypyridine-2,3-dicarboxylic acid dimethyl ester 4-HYDROXYPYRIDINE-2,6-DICARBOXYLIC ACID MONOHYDRATE,CHELIDAMIC ACID MONOHYDRATE 2-Methyl-6-hydroxypyridine-3,4-dicarboxylic acid dimethyl ester 6-Methyl-5-hydroxypyridine-2,3-dicarboxylic acid dimethyl ester 4-Ethoxy-2,6-pyridinedicarboxylic acid 6-Hydroxypyridine-3,4-dicarboxylic acid dimethyl ester Dibutyl 4-butoxy-2,6-pyridinedicarboxylate 4-Butoxy-2,6-pyridinedicarboxylic acid

4-HYDROXY-2,6-PYRIDINEDICARBOXYLIC ACID

4-HYDROXYPYRIDINE-2,6-DICARBOXYLIC ACID

4-PYRIDONE-2,6-DICARBOXYLIC ACID

AKOS 90653

1,4-DIHYDRO-4-OXO-2,6-PYRIDINEDICARBOXYLIC ACID

Chelidamic acid AldrichCPR

Chelidamic Acid Hydrate 95%

6-Carbamoyl-4-oxo-4H-pyran-2-carboxylicacid

CHELIDAMIC ACID

CHELIDAMIC ACID HYDRATE

1,4-Dihydro-4-oxo-2,6-pyridinedicarboxylic acid hydrate

4-Hydroxypyridine-2,6-dicarboxylic acid hydrate

chelidamic acid approx. 95%

Chelidamic aicd

.HELIDAMIC AICD

4-Hydroxy-2,6-pyridenedicarboxylic acid

Ammox-chelidonic acid

1,4-dihydro-4-oxopyridine-2,6-dicarboxylic acid

4-Oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid

1,4-Dihydro-4-oxo-2,6-pyridinedicarboxylic acid hydrate, 4-Hydroxypyridine-2,6-dicarboxylic acid

2,6-Pyridinedicarboxylic acid, 1,4-dihydro-4-oxo-

4-Oxo-1H-pyridine-2,6-dicarboxylic acid

4-Hydroxypyridine-2,6-dicarboxylic acid ,97%

4-Oxo-1,4-dihydropyridine-2,6-dicarboxylic acid

Chelidamic acid (4-Hydroxypyridine-2,6-dicarboxylic acid)

Pd(OH)2/C20%

Nsc3983

4-Hydroxypyridine-2,6-dicarboxylic acid hydrate ,97%

CheL

idamic acid

Chelidamic Acid Monohydrate&gt

Chelidamicaci

Chelidamic acid ISO 9001：2015 REACH

Chelidamic acid, 10 mM in DMSO

138-60-3

C7H5NO5xH2O

Building Blocks

C7 and C8

BioChemical

Biochemicals and Reagents

Pyridines

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

D to K

Enzyme Inhibitors

Glutamic Decarboxylase, L-

Heterocyclic Building Blocks

Pyridines

Miscellaneous

Heterocycle-Pyridine series