ChemicalBook > CAS DataBase List > (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester

(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester

Product Name
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
CAS No.
494769-44-7
Chemical Name
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
Synonyms
(2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL;N-Boc-2-amino-(4-hydroxymethyl)thiazole;tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate;tert-butyl 4-(hydroxymethyl)-1,3-thiazol-2-ylcarbamate;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%;Carbamic acid, N-[4-(hydroxymethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester
CBNumber
CB2221212
Molecular Formula
C9H14N2O3S
Formula Weight
230.28
MOL File
494769-44-7.mol
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(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Property

Density 
1.316±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
5.09±0.70(Predicted)
Appearance
Off-white to light brown Solid
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
H972473
Product name
(4-Hydroxymethylthiazol-2-yl)carbamicacidtert-butylester
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
H972473
Product name
(4-Hydroxymethylthiazol-2-yl)carbamicacidtert-butylester
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142903
Product name
tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142903
Product name
tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate
Packaging
1g
Price
$113
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB142903
Product name
tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate
Packaging
2g
Price
$197
Updated
2021/12/16
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(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

930303-58-5

494769-44-7

Step 2: Synthesis of tert-butyl (4-hydroxymethylthiazol-2-yl)carbamate Ethyl 2-(bis(tert-butoxycarbonyl)amino)thiazole-4-carboxylate (8.0 g, 21.5 mmol) was dissolved in 160 mL of tetrahydrofuran (THF), and cooled to -15 °C. Under stirring, lithium aluminum hydride (1 M in THF, 23.5 mL, 23.6 mmol) was added slowly and dropwise, keeping the reaction temperature at -15 °C. The reaction mixture was continued to be stirred at -15 °C for 1 hour. Upon completion of the reaction, the reaction was quenched by careful addition of water and subsequently washed with saturated aqueous D-tartaric acid potassium solution. The mixture was extracted three times with ethyl acetate and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel with ethyl acetate/heptane as eluent (5:95→50:50 gradient). The target product (4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester was obtained as a light yellow solid (3.2 g, 77% yield), mass spectrum (MS): m/e = 231.2 ([M+H]+).

References

[1] Patent: US2007/78155, 2007, A1. Location in patent: Page/Page column 32

(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester manufacturers

Career Henan Chemical Co
Product
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester 494769-44-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 653
Release date
2019-09-01

494769-44-7, (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl esterRelated Search:

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  • (4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER
  • (2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL
  • N-Boc-2-amino-(4-hydroxymethyl)thiazole
  • tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate
  • tert-butyl 4-(hydroxymethyl)-1,3-thiazol-2-ylcarbamate
  • (4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%
  • Carbamic acid, N-[4-(hydroxymethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester
  • 494769-44-7
  • API intermediates