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SERTINDOLE

Product Name
SERTINDOLE
CAS No.
106516-24-9
Chemical Name
SERTINDOLE
Synonyms
S-1991;Zerdol;Serlect;Serdoleet;LU-23-174;Serdolect;SERTINDOLE;Sertindole>SUBSTANCE 5364890;SERTINDOLE USP/EP/BP
CBNumber
CB2221267
Molecular Formula
C24H26ClFN4O
Formula Weight
440.94
MOL File
106516-24-9.mol
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SERTINDOLE Property

Melting point:
95-100°C
Boiling point:
592.1±50.0 °C(Predicted)
Density 
1.36
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
14.53±0.20(Predicted)
color 
off-white
Merck 
14,8466
InChIKey
GZKLJWGUPQBVJQ-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
NJ0621100
HS Code 
2933.99.6100
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
S0942
Product name
Sertindole
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
S0942
Product name
Sertindole
Purity
>95.0%(HPLC)
Packaging
50mg
Price
$528
Updated
2024/03/01
Cayman Chemical
Product number
23883
Product name
Sertindole
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
23883
Product name
Sertindole
Purity
≥98%
Packaging
10mg
Price
$120
Updated
2024/03/01
TRC
Product number
S279500
Product name
Sertindole
Packaging
50mg
Price
$525
Updated
2021/12/16
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SERTINDOLE Chemical Properties,Usage,Production

Description

Serdolect was launched in the UK for acute and chronic schizophrenia and schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l- (4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain and has a high affinity for the serotinin 5-HT2 receptor where it behaves as an antagonist. It has weak affinity for the α1-adrenergic receptor and no affinity for dopamine D2 receptors. It is as effective as haloperidol but without the extrapyramidal symptoms. This may be a consequence of the fact that it expresses the c-fos protein in a manner different for haloperidol but similar to clozapine. It is non-sedating, long lasting (several days after a single dose) and has an atypical mode of action.

Description

Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively). It also binds to histamine H1 and α1- and α2-adrenergic receptors (Kds = 320, 3.9, and 190 nM, respectively). In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats. Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats. It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice. Sertindole (0.02-0.32 mg/kg) also prevents accuracy deficits and anticipatory over-responding in the 5-choice serial reaction time task (5CSRTT) induced by the NMDA receptor antagonist (R)-CPP in rats. Formulations containing sertindole have been used in the treatment of schizophrenia.

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Lundbeck (Denmark)

Uses

Antipsychotic used in the treatment of schizophrenia.

Uses

antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist

Definition

ChEBI: A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-o oimidazolidin-1-yl)ethyl group.

brand name

SerLect (Abbott).

Side effects

Sertindole is an indole-containing compound that behaves as a high-affinity serotonin 5-HT2 receptor antagonist, with weak affinity for adrenergic α1 receptors and almost no affinity for dopaminergic D2 receptors. It is about as effective as haloperidol in the treatment of acute and chronic schizophrenia, but with much lower incidence of extrapyramidal side effects. Sertindole is relatively nonsedating, and its effects are long lasting (several days).

SERTINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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SERTINDOLE Suppliers

Canada 2 China 98 Europe 2 France 1 Germany 2 India 4 Japan 1 Poland 1 Sweden 1 Switzerland 1 United Kingdom 5 United States 20 Global 138
LGM Pharma
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View Lastest Price from SERTINDOLE manufacturers

Dideu Industries Group Limited
Product
SERTINDOLE 106516-24-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-23

106516-24-9, SERTINDOLERelated Search:

Penfluridol CHEMBRDG-BB 4013121 5-CHLORO-1-METHYLINDOLE 5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE 1-(4-FLUOROPHENYL)PYRROLE 5-CHLORO-3-(1-METHYL-4-PIPERIDINYL)INDOLE N-(PIPERIDINOETHYL)ETHYLENEDIAMINE 5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE 3-Piperidin-4-yl-1H-indole 3-(1-METHYL-4-PIPERIDINYL)INDOLE SERTINDOLE 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE

  • SERTINDOLE
  • SERDOLECT;SERLECT;LU 23-174
  • Serlect
  • SUBSTANCE 5364890
  • 1-(2-{4-[5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOL-3-YL]-PIPERIDIN-1-YL}-ETHYL)-IMIDAZOLIDIN-2-ONE
  • 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
  • 1-(4-Fluorophenyl)-5-chloro-3-[1-[2-[(tetrahydro-2-oxo-1H-imidazol)-1-yl]ethyl]piperidin-4-yl]-1H-indole
  • 1-[2-[4-[1-(4-Fluorophenyl)-5-chloro-1H-indole-3-yl]piperidino]ethyl]imidazolidine-2-one
  • S-1991
  • LU-23-174
  • Serdoleet
  • 2-IMidazolidinone, Sertindole
  • 2-IMidazolidinone,1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-
  • Zerdol
  • Serdolect
  • Sertindole&gt
  • SERTINDOLE USP/EP/BP
  • Maribavir Impurity 15
  • 106516-24-9
  • C24H26ClFN4O
  • C24H26ClFN3O
  • C24H22D4ClFN4O
  • Aluminium foil bag/Fluoride bottle or on your request
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Pharmaceuticals