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SENEGENIN

Product Name
SENEGENIN
CAS No.
2469-34-3
Chemical Name
SENEGENIN
Synonyms
SENEGIN;SENEGENIN;Tenuigenin;Tenuifgenin;Senegenin-RM;Tenuifolic acid;Senegenin (6CI);Senegenin, >=98%;12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid;12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid
CBNumber
CB2222527
Molecular Formula
C30H45ClO6
Formula Weight
537.13
MOL File
2469-34-3.mol
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SENEGENIN Property

Melting point:
290-292℃
alpha 
D +19° (c = 0.70 in ethanol)
Boiling point:
674.1±55.0 °C(Predicted)
Density 
1.28
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
pka
4.27±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
RTECS 
RC8815000
Toxicity
LD50 intraperitoneal in mouse: 3mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1001
Product name
Senegenin
Purity
≥98% (HPLC)
Packaging
5mg
Price
$96
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1001
Product name
Senegenin
Purity
≥98% (HPLC)
Packaging
25mg
Price
$464
Updated
2023/06/20
Cayman Chemical
Product number
28824
Product name
Tenuigenin
Packaging
5mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
28824
Product name
Tenuigenin
Packaging
100mg
Price
$975
Updated
2024/03/01
Cayman Chemical
Product number
28824
Product name
Tenuigenin
Packaging
10mg
Price
$143
Updated
2024/03/01
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SENEGENIN Chemical Properties,Usage,Production

Description

Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.

Uses

Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.

Definition

ChEBI: Senegenin is a 12alpha-hydroxy steroid.

SENEGENIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SENEGENIN Suppliers

Nantong Feiyu Biological Technology CO.,LTD
Tel
0513-68819626; 15152877458
Fax
0513-68669626
Email
feiyubio@163.com
Country
China
ProdList
4819
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Aktin Chemicals, Inc.
Tel
86-28-85159085
Fax
86-28-85152372
Email
info@aktinchem.com
Country
China
ProdList
297
Advantage
62
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
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View Lastest Price from SENEGENIN manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
SENEGENIN 2469-34-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-22
Shanghai Standard Technology Co., Ltd.
Product
Senegenin 2469-34-3
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-09-24
Shanghai Standard Technology Co., Ltd.
Product
Senegenin 2469-34-3
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-09-24

2469-34-3, SENEGENINRelated Search:


  • SENEGENIN
  • SENEGIN
  • 13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid
  • 28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2
  • 27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2,3-dihydroxy-, (2β,3β,4α,12α)-
  • Tenuigenin
  • 12α-(Chloromethyl)-2β,3β-dihydroxy-27-nor-5α-olean-13-ene-23,28-dioic acid
  • 12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid
  • Tenuifolic acid
  • (2beta,3beta,4alpha,12alpha)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid
  • 12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid
  • Senegenin, >=98%
  • Tenuifgenin
  • (2S,3R,4S,4aR,6aR,8aS,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid
  • 13-(Chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydro-4,8a(1H)-picenedicarboxylic acid
  • Senegenin (6CI)
  • Senegenin-RM
  • 2469-34-3
  • C30H45ClO6
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract