SENEGENIN

Product Name: SENEGENIN
CAS No.: 2469-34-3
Chemical Name: SENEGENIN
Synonyms: SENEGIN;SENEGENIN;Tenuigenin;Tenuifgenin;Senegenin-RM;Tenuifolic acid;Senegenin (6CI);Senegenin, >=98%;Tenuigenin (Senegenin);Tenuigenin, 10 mM in DMSO
CBNumber: CB2222527
Molecular Formula: C30H45ClO6
Formula Weight: 537.13
MOL File: 2469-34-3.mol

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SENEGENIN Property

Melting point:: 290-292℃
alpha: D +19° (c = 0.70 in ethanol)
Boiling point:: 674.1±55.0 °C(Predicted)
Density: 1.28
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 4.27±0.70(Predicted)
form: powder
color: white to beige
InChIKey: CWHJIJJSDGEHNS-JEKQWPLRNA-N
SMILES: C[C@]12C[C@H](O)[C@H](O)[C@@](C)(C(=O)O)[C@]1([H])CC[C@]1(C3CC[C@]4(CCC(C)(C)C[C@@]4([H])C=3[C@@H](CCl)C[C@]21[H])C(=O)O)C |&1:1,3,5,7,12,16,20,27,30,34,r|

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Safety

WGK Germany: 3
RTECS: RC8815000
Toxicity: LD50 intraperitoneal in mouse: 3mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1001
Product name: Senegenin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $71.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1001
Product name: Senegenin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2023/06/20

Cayman Chemical

Product number: 28824
Product name: Tenuigenin
Packaging: 5mg
Price: $75
Updated: 2024/03/01

Cayman Chemical

Product number: 28824
Product name: Tenuigenin
Packaging: 100mg
Price: $975
Updated: 2024/03/01

Cayman Chemical

Product number: 28824
Product name: Tenuigenin
Packaging: 10mg
Price: $143
Updated: 2024/03/01

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SENEGENIN Chemical Properties,Usage,Production

Description

Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Polygala tenuifolia.

Uses

Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.

Definition

ChEBI: Senegenin is a 12alpha-hydroxy steroid.

in vivo

Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice^[1].

IC 50

NF-κB

References

[1] J. J. DUGAN A S P Mayo. TERPENOIDS: V. SENEGENIN: FUNCTIONAL GROUPS AND PART STRUCTURE[J]. Canadian Journal of Chemistry, 1964, 143 1: 491-501. DOI: 10.1139/v64-073
[2] ZHENG FAN. Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia.[J]. Journal of Neuroinflammation, 2017: 256. DOI: 10.1186/s12974-017-1036-x
[3] BIN YU . Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice[J]. Microbial pathogenesis, 2017, 110: Pages 385-389. DOI: 10.1016/j.micpath.2017.07.023

SENEGENIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SENEGENIN Suppliers

China 207 United Kingdom 2 United States 15 Global 224

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
ProdList: 297
Advantage: 62

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

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View Lastest Price from SENEGENIN manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: SENEGENIN 2469-34-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-22

Shanghai Standard Technology Co., Ltd.

Product: Senegenin 2469-34-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-24

Shanghai Standard Technology Co., Ltd.

Product: Senegenin 2469-34-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-09-24

2469-34-3, SENEGENINRelated Search:

Onjisaponin Z Polygalacic acid Sinegin 3 polygalaxanthone III Polygalacin D Polygalaxanthone XI Tenuifoliside C polygalic acid 1,11-Undecanedicarboxylic acid 2-DECYL-1-TETRADECANOL 1-Chlorooctadecane HEPTADECANEDIOIC ACID TRIPLAL Pentadecanedioic acid 3,3,5,5-TETRAMETHYLCYCLOHEXANOL CETONAL 19-METHYLEICOSANOIC ACID HELLEBRIN

SENEGENIN

SENEGIN

13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid

28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2

27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2,3-dihydroxy-, (2β,3β,4α,12α)-

Tenuigenin

12α-(Chloromethyl)-2β,3β-dihydroxy-27-nor-5α-olean-13-ene-23,28-dioic acid

12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid

Tenuifolic acid

(2beta,3beta,4alpha,12alpha)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid

12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid

Senegenin, >=98%

Tenuifgenin

(2S,3R,4S,4aR,6aR,8aS,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid

13-(Chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydro-4,8a(1H)-picenedicarboxylic acid

Senegenin (6CI)

Senegenin-RM

Tenuigenin, 10 mM in DMSO

Tenuigenin (Senegenin)

(2S,3R,4R,6aR,8aR,12aR,13S,14aR,14bR)-13-(Chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydropicene-4,8a(1H)-dicarboxylic acid

2469-34-3

C30H45ClO6

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract