2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE

Product Name: 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE
CAS No.: 106086-78-6
Chemical Name: 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE
Synonyms: 2-BroMoMethyl benzothizaole;2-(BROMOMETHYL)BENZOTHIAZOLE;Benzothiazole,2-(broMoMethyl)-;2-(bromomethyl)benzo[d]thiazole;2-(Bromomethyl)-1,3-benzothiazol;2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE;2-(Bromomethyl)benzothiazole, 98+%;[(Benzo[d]thiazol-2-yl)methyl]bromide;2-(Bromomethyl)-1,3-benzothiazole ,95%
CBNumber: CB2225922
Molecular Formula: C8H6BrNS
Formula Weight: 228.11
MOL File: 106086-78-6.mol

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2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE Property

Melting point:: 47 °C
Boiling point:: 288℃
Density: 1.680
Flash point:: 128℃
storage temp.: Inert atmosphere,2-8°C
pka: 0.38±0.10(Predicted)
form: crystalline powder
color: Pale yellow
CAS DataBase Reference: 106086-78-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C,Xn
Risk Statements: 34-41-37/38-22
Safety Statements: 26-36/37/39-36/37/3945-39
RIDADR: 3261
Hazard Note: Irritant
HazardClass: 8
PackingGroup: III
HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6226
Product name: 2-(Bromomethyl)-1,3-benzothiazole
Purity: min. 98.0 %
Packaging: 1G
Price: $108
Updated: 2025/07/31

TCI Chemical

Product number: B6226
Product name: 2-(Bromomethyl)-1,3-benzothiazole
Purity: min. 98.0 %
Packaging: 5G
Price: $429
Updated: 2025/07/31

TRC

Product number: B697078
Product name: 2-(Bromomethyl)-1,3-benzothiazole
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: OR23090
Product name: 2-(Bromomethyl)-1,3-benzothiazole
Packaging: 100mg
Price: $17
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-9-X7
Product name: 2-(Bromomethyl)-1,3-benzothiazole
Packaging: 100mg
Price: $20
Updated: 2021/12/16

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2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE Chemical Properties,Usage,Production

Synthesis

37859-42-0

106086-78-6

The general procedure for the synthesis of 2-(bromomethyl)benzothiazole using 2-hydroxymethylbenzothiazole as starting material was as follows: 2-hydroxymethylbenzothiazole (1.00 g, 6.05 mmol) was dissolved in an appropriate amount of CH2Cl2 according to Attardo's method 1. Phosphorus tribromide (1.15 mL, 12.1 mmol) was slowly added dropwise to the above solution under argon protection. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent ratio hexane:ethyl acetate = 5:1) to afford 2-(bromomethyl)benzothiazole (786 mg, 57% yield) as a brown solid. The structure of the product was confirmed by the following characterization data: 1H NMR (300 MHz, CDCl3) δ 4.81 (s, 2H), 7.42 (td, 1H, J = 8.1 Hz, 1.1 Hz), 7.50 (td, 1H, J = 8.1 Hz, 1.1 Hz), 7.87 (dd, 1H, J = 8.1 Hz, 1.1 Hz), 8.02 ( dd, 1H, J = 8.1 Hz, 1.1 Hz); 13C NMR (75 MHz, CDCl3) δ 27.1, 121.8, 123.5, 125.9, 126.5, 136.2, 152.8, 166.2; mass spectrometry (EI) showed molecular ion peaks at m/z 227, 229 (M+); and thin-layer chromatography (TLC) showed Rf value of 0.60 (unfolding agent ratio of hexane:ethyl acetate=5:1).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 43 - 45
[2] Patent: WO2017/66606, 2017, A1. Location in patent: Page/Page column 95; 96
[3] Journal of the American Chemical Society, 2017, vol. 139, # 21, p. 7318 - 7334
[4] Patent: WO2018/191394, 2018, A1. Location in patent: Page/Page column 135-136
[5] Zhurnal Obshchei Khimii, 1951, vol. 21, p. 2055,2056, 2061; engl. Ausg. S. 2295, 2301

2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE Suppliers

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View Lastest Price from 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-2,1,3-BENZOTHIADIAZOLE 106086-78-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: customise
Release date: 2018-08-09

106086-78-6, 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLERelated Search:

3-Fluoro-4-broMo-6-aMinotoluene 4-Bromo-2-methylpyridine 5-Bromo-2-methoxyphenol 6-(Bromomethyl)-1,3-benzothiazole,6-(BROMOMETHYL)-1,3-BENZOTHIAZOLE,97% 2-(BROMOMETHYL)-5,6-DIFLUORO-1,3-BENZOTHIAZOLE 2-(BROMOMETHYL)-5-FLUOROBENZOTHIAZOLE 2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE 2-(BROMOMETHYL)-5-(TRIFLUOROMETHYL) BENZOTHIAZOLE 2-(BROMODIFLUOROMETHYL)BENZO[D]THIAZOLE

2-(BROMOMETHYL)BENZOTHIAZOLE

2-(BROMOMETHYL)-1,3-BENZOTHIAZOLE

2-(Bromomethyl)benzothiazole, 98+%

2-(bromomethyl)benzo[d]thiazole

2-(Bromomethyl)-1,3-benzothiazole ,95%

Benzothiazole,2-(broMoMethyl)-

2-BroMoMethyl benzothizaole

[(Benzo[d]thiazol-2-yl)methyl]bromide

2-(Bromomethyl)-1,3-benzothiazol

106086-78-6

C8H6BrNS

ALKYL HALIDE