MDL-29951
- Product Name
- MDL-29951
- CAS No.
- 130798-51-5
- Chemical Name
- MDL-29951
- Synonyms
- CS-1105;MDL-29951, >=98%;MDL-29951; MDL29951;2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid;2-Carboxy-4,6-dichloro-1H-indole-3-propionic acid;3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid;1H-Indole-3-propanoic acid, 2-carboxy-4,6-dichloro-;3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid;MDL-29951 2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid
- CBNumber
- CB22292210
- Molecular Formula
- C12H9Cl2NO4
- Formula Weight
- 302.11
- MOL File
- 130798-51-5.mol
MDL-29951 Property
- Melting point:
- 273-280℃
- Boiling point:
- 582.5±45.0 °C(Predicted)
- Density
- 1.657±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
- form
- solid
- pka
- 4.04±0.30(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of pruchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16266
- Product name
- MDL 29951
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $51
- Updated
- 2024/03/01
- Product number
- 16266
- Product name
- MDL 29951
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 16266
- Product name
- MDL 29951
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $202
- Updated
- 2024/03/01
- Product number
- 16266
- Product name
- MDL 29951
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $354
- Updated
- 2024/03/01
- Product number
- M199790
- Product name
- MDL29951
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
MDL-29951 Chemical Properties,Usage,Production
Description
NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 μM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.
Uses
MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase.
References
1) Hennen?et al. (2013),?Decoding Signaling and Function of the Orphan Protein-Coupled Receptor GPR17 with a small molecule agonist; Sci. Signal.,?6?ra93 2) Salituro?et al. (1992)?3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site; J. Med. Chem.,?35?1791
MDL-29951 Preparation Products And Raw materials
Raw materials
Preparation Products
MDL-29951 Suppliers
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View Lastest Price from MDL-29951 manufacturers
- Product
- MDL-29951 130798-51-5
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03