4-METHYL (1H)INDAZOLE
- Product Name
- 4-METHYL (1H)INDAZOLE
- CAS No.
- 3176-63-4
- Chemical Name
- 4-METHYL (1H)INDAZOLE
- Synonyms
- 4-METHYLINDAZOLE;4-METHYL (1H)INDAZOLE;1H-Indazole, 4-methyl-;4-methyl-1H-indazole(SALTDATA: FREE)
- CBNumber
- CB2241142
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 3176-63-4.mol
4-METHYL (1H)INDAZOLE Property
- Melting point:
- 114-116℃
- Boiling point:
- 285.1±9.0 °C(Predicted)
- Density
- 1.186±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 14.47±0.40(Predicted)
- Appearance
- White to light yellow Solid
N-Bromosuccinimide Price
- Product number
- CBR00232
- Product name
- 4-Methyl-1H-indazole
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- M321530
- Product name
- 4-Methyl-1H-indazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 126365
- Product name
- 4-Methyl-1H-indazole
- Purity
- >95%
- Packaging
- 5g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- 126365
- Product name
- 4-Methyl-1H-indazole
- Purity
- >95%
- Packaging
- 10g
- Price
- $900
- Updated
- 2021/12/16
- Product number
- CHM0012040
- Product name
- 4-METHYL-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2001.04
- Updated
- 2021/12/16
4-METHYL (1H)INDAZOLE Chemical Properties,Usage,Production
Synthesis
87-59-2
3176-63-4
General procedure for the synthesis of 4-methyl-1H-indazole from 2,3-dimethylaniline: Step A: Synthesis of 4-methyl-1H-indazole Tert-butyl nitrite (30 mL, 248 mmol) was slowly added to a solution of commercially available 2,3-dimethylaniline (20 mL, 165 mmol) in chloroform (600 mL) at room temperature and under nitrogen protection and the reaction mixture was stirred for 15 min. Subsequently, 18-crown-6 (4.3 g, 16.5 mmol) and potassium acetate (32 g, 333 mmol) were added and stirring was continued for 45 minutes. The reaction mixture was heated to reflux for 1 hour, then tert-butyl nitrite (10 mL, 82 mmol) was added and heating and refluxing was continued for 1 hour. After completion of the reaction, the mixture was cooled, the solid precipitate was removed by filtration, and the solids were washed with chloroform (3 x 200 mL). The filtrates were combined, washed with deionized water (400 mL) and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by fast column chromatography on silica gel with the eluent of petroleum ether/ethyl acetate (9:1, v/v) to afford 4-methyl-1H-indazole as an off-white solid (5.4 g, 25% yield). Product characterization data: 1H NMR (CDCl3) δ 2.7 (s, 3H), 6.90 (d, 1H), 7.50 (m, 2H), 8.10 (s, 1H).
References
[1] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 104-105
[2] Journal of Organic Chemistry, 1941, vol. 6, p. 427,431
[3] Helvetica Chimica Acta, 1979, vol. 62, p. 234,254
[4] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270
4-METHYL (1H)INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-METHYL (1H)INDAZOLE manufacturers
- Product
- 4-METHYL (1H)INDAZOLE 3176-63-4
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-08
- Product
- 4-METHYL (1H)INDAZOLE 3176-63-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04