METHYL 2-HYDROXY-5-IODONICOTINATE

Product Name: METHYL 2-HYDROXY-5-IODONICOTINATE
CAS No.: 116387-40-7
Chemical Name: METHYL 2-HYDROXY-5-IODONICOTINATE
Synonyms: ethyl 2-hydroxy-5-iodonicotinate;METHYL 2-HYDROXY-5-IODONICOTINATE;2-Hydroxy-5-iodo-nicotinic acid methyl ester;Methyl 2-hydroxy-5-iodopyridine-3-carboxylate;methyl 5-iodo-2-oxo-1H-pyridine-3-carboxylate;METHYL 2-HYDROXY-5-IODONICOTINATE ISO 9001：2015 REACH;METHYL 5-IODO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate;2-Hydroxy-5-iodopyridine-3-carboxylic acid methyl ester;5-Iodo-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid Methyl ester
CBNumber: CB2241430
Molecular Formula: C7H6INO3
Formula Weight: 279.03
MOL File: 116387-40-7.mol

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METHYL 2-HYDROXY-5-IODONICOTINATE Property

Melting point:: 199-201°
Boiling point:: 362.2±42.0 °C(Predicted)
Density: 1.98±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.20±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H943668
Product name: 2-Hydroxy-5-iodo-nicotinicAcidMethylEster
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 2686AA
Product name: Methyl5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate
Packaging: 1g
Price: $89
Updated: 2021/12/16

Matrix Scientific

Product number: 045777
Product name: Methyl 5-iodo-2-oxo-1,2-dihydro-3-pyridinecarboxylate
Purity: >95%
Packaging: 500mg
Price: $98
Updated: 2021/12/16

Matrix Scientific

Product number: 045777
Product name: Methyl 5-iodo-2-oxo-1,2-dihydro-3-pyridinecarboxylate
Purity: >95%
Packaging: 1g
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 059089
Product name: 2-Hydroxy-5-iodo-nicotinic acid methyl ester
Purity: 95%+
Packaging: 500mg
Price: $303
Updated: 2021/12/16

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METHYL 2-HYDROXY-5-IODONICOTINATE Chemical Properties,Usage,Production

Synthesis

10128-91-3

116387-40-7

The general procedure for the synthesis of methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate from methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate was as follows: methyl 2-hydroxynicotinate (20 g) was dissolved in dichloromethane (500 mL) at room temperature, followed by the addition of N-iodosuccinimide (NIS, 38 g). The reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the solvent was removed by evaporation. Ethyl acetate (200 mL) was added to the residue and heated under reflux conditions for 2 hours. The reaction mixture was cooled and the insoluble solid was collected by filtration to afford the target product methyl 2-hydroxy-5-iodonicotinate (30 g, 81% yield) as a white solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.97 (s, 3H), 8.33 (brs, 1H), 8.43 (d, J=2.4Hz, 1H).

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[2] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 41
[3] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 59-60
[4] Patent: US2005/203081, 2005, A1. Location in patent: Page/Page column 13
[5] Patent: WO2008/76425, 2008, A1. Location in patent: Page/Page column 54

METHYL 2-HYDROXY-5-IODONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-HYDROXY-5-IODONICOTINATE Suppliers

China 58 Germany 1 India 2 United Kingdom 2 United States 7 Global 70

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View Lastest Price from METHYL 2-HYDROXY-5-IODONICOTINATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 2-HYDROXY-5-IODONICOTINATE 116387-40-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

116387-40-7, METHYL 2-HYDROXY-5-IODONICOTINATERelated Search:

2-Hydroxy-5-iodo-3-methylpyridine METHYL 5-IODO-2-OXO-1-[4-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ALLYL IODIDE 5-IODONICOTINIC ACID 2-Hydroxy-5-iodopyridine (5-IODO-PYRIDIN-3-YL)-METHANOL 5-IODO-PYRIDINE-3-CARBALDEHYDE METHYL 2-HYDROXY-5-IODONICOTINATE

2-Hydroxy-5-iodo-nicotinic acid methyl ester

Methyl 2-hydroxy-5-iodopyridine-3-carboxylate

5-Iodo-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid Methyl ester

2-Hydroxy-5-iodopyridine-3-carboxylic acid methyl ester

Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate

ethyl 2-hydroxy-5-iodonicotinate

METHYL 5-IODO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE

METHYL 2-HYDROXY-5-IODONICOTINATE

3-Pyridinecarboxylic acid, 1,2-dihydro-5-iodo-2-oxo-, methyl ester

METHYL 2-HYDROXY-5-IODONICOTINATE ISO 9001：2015 REACH

methyl 5-iodo-2-oxo-1H-pyridine-3-carboxylate

116387-40-7