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METHYL 2-HYDROXY-5-IODONICOTINATE

Product Name
METHYL 2-HYDROXY-5-IODONICOTINATE
CAS No.
116387-40-7
Chemical Name
METHYL 2-HYDROXY-5-IODONICOTINATE
Synonyms
ethyl 2-hydroxy-5-iodonicotinate;METHYL 2-HYDROXY-5-IODONICOTINATE;2-Hydroxy-5-iodo-nicotinic acid methyl ester;Methyl 2-hydroxy-5-iodopyridine-3-carboxylate;methyl 5-iodo-2-oxo-1H-pyridine-3-carboxylate;METHYL 2-HYDROXY-5-IODONICOTINATE ISO 9001：2015 REACH;METHYL 5-IODO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate;2-Hydroxy-5-iodopyridine-3-carboxylic acid methyl ester;5-Iodo-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid Methyl ester
CBNumber
CB2241430
Molecular Formula
C7H6INO3
Formula Weight
279.03
MOL File
116387-40-7.mol
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METHYL 2-HYDROXY-5-IODONICOTINATE Property

Melting point:
199-201°
Boiling point:
362.2±42.0 °C(Predicted)
Density 
1.98±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
8.20±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
H943668
Product name
2-Hydroxy-5-iodo-nicotinicAcidMethylEster
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
2686AA
Product name
Methyl5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate
Packaging
1g
Price
$89
Updated
2021/12/16
Matrix Scientific
Product number
045777
Product name
Methyl 5-iodo-2-oxo-1,2-dihydro-3-pyridinecarboxylate
Purity
>95%
Packaging
500mg
Price
$98
Updated
2021/12/16
Matrix Scientific
Product number
045777
Product name
Methyl 5-iodo-2-oxo-1,2-dihydro-3-pyridinecarboxylate
Purity
>95%
Packaging
1g
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
059089
Product name
2-Hydroxy-5-iodo-nicotinic acid methyl ester
Purity
95%+
Packaging
500mg
Price
$303
Updated
2021/12/16
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METHYL 2-HYDROXY-5-IODONICOTINATE Chemical Properties,Usage,Production

Synthesis

10128-91-3

116387-40-7

The general procedure for the synthesis of methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate from methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate was as follows: methyl 2-hydroxynicotinate (20 g) was dissolved in dichloromethane (500 mL) at room temperature, followed by the addition of N-iodosuccinimide (NIS, 38 g). The reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the solvent was removed by evaporation. Ethyl acetate (200 mL) was added to the residue and heated under reflux conditions for 2 hours. The reaction mixture was cooled and the insoluble solid was collected by filtration to afford the target product methyl 2-hydroxy-5-iodonicotinate (30 g, 81% yield) as a white solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.97 (s, 3H), 8.33 (brs, 1H), 8.43 (d, J=2.4Hz, 1H).

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[2] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 41
[3] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 59-60
[4] Patent: US2005/203081, 2005, A1. Location in patent: Page/Page column 13
[5] Patent: WO2008/76425, 2008, A1. Location in patent: Page/Page column 54

METHYL 2-HYDROXY-5-IODONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 2-HYDROXY-5-IODONICOTINATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
METHYL 2-HYDROXY-5-IODONICOTINATE 116387-40-7
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13

116387-40-7, METHYL 2-HYDROXY-5-IODONICOTINATERelated Search:

2-Hydroxy-5-iodo-3-methylpyridine METHYL 5-IODO-2-OXO-1-[4-(TRIFLUOROMETHYL)BENZYL]-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ALLYL IODIDE 5-IODONICOTINIC ACID 2-Hydroxy-5-iodopyridine (5-IODO-PYRIDIN-3-YL)-METHANOL 5-IODO-PYRIDINE-3-CARBALDEHYDE METHYL 2-HYDROXY-5-IODONICOTINATE

  • 2-Hydroxy-5-iodo-nicotinic acid methyl ester
  • Methyl 2-hydroxy-5-iodopyridine-3-carboxylate
  • 5-Iodo-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid Methyl ester
  • 2-Hydroxy-5-iodopyridine-3-carboxylic acid methyl ester
  • Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate
  • ethyl 2-hydroxy-5-iodonicotinate
  • METHYL 5-IODO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
  • METHYL 2-HYDROXY-5-IODONICOTINATE
  • 3-Pyridinecarboxylic acid, 1,2-dihydro-5-iodo-2-oxo-, methyl ester
  • METHYL 2-HYDROXY-5-IODONICOTINATE ISO 9001：2015 REACH
  • methyl 5-iodo-2-oxo-1H-pyridine-3-carboxylate
  • 116387-40-7