PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

Product Name: PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
CAS No.: 1638-41-1
Chemical Name: PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
Synonyms: p38 MAPK Inhibitor IV;p38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV (B10);2,2'-Sulfonylbis(3,4,6-trichlorophenol);PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-;p38 MAP Kinase Inhibitor IV,p-38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem;Phenol, 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-
CBNumber: CB22446185
Molecular Formula: C12H4Cl6O4S
Formula Weight: 456.94
MOL File: 1638-41-1.mol

More

Less

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Property

Melting point:: 244-245 °C(Solv: ethyl acetate (141-78-6))
Boiling point:: 590.0±50.0 °C(Predicted)
Density: 1.854±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 2.43±0.50(Predicted)
form: powder
color: white to beige

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0543
Product name: p38 MAP Kinase Inhibitor IV
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: 506153
Product name: p38 MAP Kinase Inhibitor IV
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 22219
Product name: p38 MAPK Inhibitor IV
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 22219
Product name: p38 MAPK Inhibitor IV
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0543
Product name: p38 MAP Kinase Inhibitor IV
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $440
Updated: 2022/05/15

More

Less

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Chemical Properties,Usage,Production

Uses

p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor.

Uses

p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling.

General Description

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC₅₀ = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 μM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).

Biochem/physiol Actions

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Suppliers

China 23 Finland 1 United Kingdom 1 United States 8 Global 33

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

1638-41-1, PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-Related Search:

4-Nitrobenzenesulfonyl chloride Dichlorophen 1,3-dichloro-5-(methylsulphonyl)benzene 2,3-DICHLOROTHIOPHENOL Bithionol 3,5-DICHLOROTHIOANISOLE 2-(METHYLSULFONYL)PHENOL BIS(2-HYDROXY-5-CHLOROPHENYL) SULFIDE BITHIONOL SULFOXIDE 4-CHLORO-2-[(5-CHLORO-2-HYDROXYPHENYL)SULFONYL]PHENOL 1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

2,2'-Sulfonylbis(3,4,6-trichlorophenol)

p38 MAP Kinase Inhibitor IV

p38 MAPK Inhibitor IV

p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem

Phenol, 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-

p38 MAP Kinase Inhibitor IV (B10)

p38 MAP Kinase Inhibitor IV,p-38 MAP Kinase Inhibitor IV

1638-41-1

C12H4Cl6O4S