4-(CHLOROMETHYL)-2-METHYLPYRIDINE
- Product Name
- 4-(CHLOROMETHYL)-2-METHYLPYRIDINE
- CAS No.
- 75523-42-1
- Chemical Name
- 4-(CHLOROMETHYL)-2-METHYLPYRIDINE
- Synonyms
- 4-(Chloromethyl)-2-picoline;2-Methyl-4-(chloromethyl)pyridine;4-(CHLOROMETHYL)-2-METHYLPYRIDINE;pyridine, 4-(chloroMethyl)-2-Methyl-;4-Chloromethyl-2-methyl-pyridine.HCL;2-methyl-pyridin-4-ylmethyl chloride;2-Methyl-4-(chloromethyl)pyridine (HCl)
- CBNumber
- CB22454432
- Molecular Formula
- C7H8ClN
- Formula Weight
- 141.6
- MOL File
- 75523-42-1.mol
4-(CHLOROMETHYL)-2-METHYLPYRIDINE Property
- Boiling point:
- 218℃
- Density
- 1.118
- Flash point:
- 106℃
N-Bromosuccinimide Price
- Product number
- C369655
- Product name
- 4-Chloromethyl-2-methylpyridine
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- D2223
- Product name
- 4-(chloromethyl)-2-methyl-Pyridine
- Purity
- 97.00%
- Packaging
- 1G
- Price
- $2100
- Updated
- 2021/12/16
- Product number
- D2223
- Product name
- 4-(chloromethyl)-2-methyl-Pyridine
- Purity
- 97.00%
- Packaging
- 5G
- Price
- $3590
- Updated
- 2021/12/16
- Product number
- D2223
- Product name
- 4-(chloromethyl)-2-methyl-Pyridine
- Purity
- 97.00%
- Packaging
- 25G
- Price
- $6710
- Updated
- 2021/12/16
4-(CHLOROMETHYL)-2-METHYLPYRIDINE Chemical Properties,Usage,Production
Uses
4-Chloromethyl-2-methylpyridine is used in the preparation of HIV-1 protease inhibitors.
Synthesis
4-(Chloromethyl)-2-methylpyridine is synthesised using (2-Methylpyridin-4-yl)methanol as a raw material by chemical reaction. The specific synthesis steps are as follows:
5-[(2-Chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-[4-(2-methylpyridyl)]isoxazole a) 4-Chloromethyl-2-methylpyridine; Into 100 mL of methylene chloride solution containing 2. 1-6 g of 4-(2-methylpyridyl)methanol (cf. PCT International Publication WO98/2120 Pamphlet), 23 mL of thionyl chloride was dropped at room temperature, followed by 20 hours' stirring at room temperature. The solvent was distilled off from the reaction solution under reduced pressure, and the residue was extracted with methylene chloride, after addition of saturated aqueous NaHCO3 solution. The methylene chloride extract was dried over anhydrous magnesium sulfate, and from which the solvent was distilled off under reduced pressure to provide 2.46 g (yield: 100%) of brown crystalline title compound. 1H-NMR(CDCl3)delta:8.45(d,J=5.0Hz,1H),7.31(s,1H), 7.25(d,J=5.0Hz,1H),4.74(s,2H),2.48(s,3H) Mass,m/e:141 (M+,base).
4-(CHLOROMETHYL)-2-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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