ChemicalBook > CAS DataBase List > 4-(CHLOROMETHYL)-2-METHYLPYRIDINE

4-(CHLOROMETHYL)-2-METHYLPYRIDINE

Product Name
4-(CHLOROMETHYL)-2-METHYLPYRIDINE
CAS No.
75523-42-1
Chemical Name
4-(CHLOROMETHYL)-2-METHYLPYRIDINE
Synonyms
4-(Chloromethyl)-2-picoline;2-Methyl-4-(chloromethyl)pyridine;4-(CHLOROMETHYL)-2-METHYLPYRIDINE;pyridine, 4-(chloroMethyl)-2-Methyl-;4-Chloromethyl-2-methyl-pyridine.HCL;2-methyl-pyridin-4-ylmethyl chloride;2-Methyl-4-(chloromethyl)pyridine (HCl)
CBNumber
CB22454432
Molecular Formula
C7H8ClN
Formula Weight
141.6
MOL File
75523-42-1.mol
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4-(CHLOROMETHYL)-2-METHYLPYRIDINE Property

Boiling point:
218℃
Density 
1.118
Flash point:
106℃
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C369655
Product name
4-Chloromethyl-2-methylpyridine
Packaging
5g
Price
$1320
Updated
2021/12/16
AccelPharmtech
Product number
D2223
Product name
4-(chloromethyl)-2-methyl-Pyridine
Purity
97.00%
Packaging
1G
Price
$2100
Updated
2021/12/16
AccelPharmtech
Product number
D2223
Product name
4-(chloromethyl)-2-methyl-Pyridine
Purity
97.00%
Packaging
5G
Price
$3590
Updated
2021/12/16
AccelPharmtech
Product number
D2223
Product name
4-(chloromethyl)-2-methyl-Pyridine
Purity
97.00%
Packaging
25G
Price
$6710
Updated
2021/12/16
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4-(CHLOROMETHYL)-2-METHYLPYRIDINE Chemical Properties,Usage,Production

Uses

4-Chloromethyl-2-methylpyridine is used in the preparation of HIV-1 protease inhibitors.

Synthesis

4-(Chloromethyl)-2-methylpyridine is synthesised using (2-Methylpyridin-4-yl)methanol as a raw material by chemical reaction. The specific synthesis steps are as follows:
5-[(2-Chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-[4-(2-methylpyridyl)]isoxazole a) 4-Chloromethyl-2-methylpyridine; Into 100 mL of methylene chloride solution containing 2. 1-6 g of 4-(2-methylpyridyl)methanol (cf. PCT International Publication WO98/2120 Pamphlet), 23 mL of thionyl chloride was dropped at room temperature, followed by 20 hours' stirring at room temperature. The solvent was distilled off from the reaction solution under reduced pressure, and the residue was extracted with methylene chloride, after addition of saturated aqueous NaHCO3 solution. The methylene chloride extract was dried over anhydrous magnesium sulfate, and from which the solvent was distilled off under reduced pressure to provide 2.46 g (yield: 100%) of brown crystalline title compound. 1H-NMR(CDCl3)delta:8.45(d,J=5.0Hz,1H),7.31(s,1H), 7.25(d,J=5.0Hz,1H),4.74(s,2H),2.48(s,3H) Mass,m/e:141 (M+,base).

4-(CHLOROMETHYL)-2-METHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(CHLOROMETHYL)-2-METHYLPYRIDINE Suppliers

Canada 1 China 22 India 1 United Kingdom 1 United States 3 Global 28
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75523-42-1, 4-(CHLOROMETHYL)-2-METHYLPYRIDINERelated Search:

2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE 4-(CHLOROMETHYL)-2-METHYLPYRIDINE 4-QUINOLINECARBONYL CHLORIDE,6-CHLORO-2-PHENYL- Quinoline, 4-(chloromethyl)-2-methyl- (9CI) 2-Phenylquinoline-4-carboxylicacidchloride 6-bromo-2-phenylquinoline-4-carbonyl chloride 4-(CHLOROMETHYL)PYRIDINE-2-CARBONITRILE ETHYL 4-(CHLOROMETHYL)PYRIDINE-2-CARBOXYLATE 4-(CHLOROMETHYL)-2-PHENYLPYRIDINE 4-DICHLOROMETHYL-6-METHYL-2-PHENYL-QUINOLINE 4-[CHLORO(DIFLUORO)METHYL]-2-HYDROXY-6-[4-(TRIFLUOROMETHYL)PHENYL]NICOTINONITRILE 4-DICHLOROMETHYL-2-PHENYL-QUINOLINE 4-(CHLOROMETHYL)-2-(3,4,5-TRIMETHOXYPHENYL)PYRIDINE 4-(CHLOROMETHYL)-2-(4-FLUOROPHENYL)PYRIDINE 2-PHENYL-QUINOLINE-4-CARBONYL CHLORIDE HYDROCHLORIDE 4-[CHLORO(DIFLUORO)METHYL]-2-HYDROXY-6-METHYLNICOTINONITRILE 2,4-BIS(TRICHLOROMETHYL)-7-CHLOROQUINOLINE 2,4-BIS(TRICHLOROMETHYL)QUINOLINE

  • 4-(CHLOROMETHYL)-2-METHYLPYRIDINE
  • pyridine, 4-(chloroMethyl)-2-Methyl-
  • 4-(Chloromethyl)-2-picoline
  • 2-Methyl-4-(chloromethyl)pyridine
  • 2-methyl-pyridin-4-ylmethyl chloride
  • 4-Chloromethyl-2-methyl-pyridine.HCL
  • 2-Methyl-4-(chloromethyl)pyridine (HCl)
  • 75523-42-1
  • Aromatics, Heterocycles, Miscellaneous Reagents